The global response to COVID-19 has demonstrated the importance of vigilance and preparedness for infectious diseases, particularly influenza. There is a need for more effective influenza vaccines and modern manufacturing technologies that are adaptable and scalable to meet demand during a pandemic. The rapid development of COVID-19 vaccines has demonstrated what is possible with extensive data sharing, researchers who have the necessary resources and novel technologies to conduct and apply their research, rolling review by regulators, and public-private partnerships. As demonstrated throughout the response to COVID-19, the process of research and development of novel vaccines can be significantly optimized when stakeholders are provided with the resources and technologies needed to support their response. Vaccine Research and Development to Advance Pandemic and Seasonal Influenza Preparedness and Response focuses on how to leverage the knowledge gained from the COVID-19 pandemic to optimize vaccine research and development (R&D) to support the prevention and control of seasonal and pandemic influenza. The committee's findings address four dimensions of vaccine R&D: (1) basic and translational science, (2) clinical science, (3) manufacturing science, and (4) regulatory science.

The final product of the Strategic Highway Research Program (SHRP) Asphalt Research Program is the SUPERPAVE (registered trademark) mix design system for new construction and overlays. This system employs a series of new performance-based specifications, test methods, and practices for material selection, accelerated performance testing, and mix design. This report documents these new specifications and procedures in a format suitable for eventual American Association of State Highway and Transportation Officials (AASHTO) standardization.

"Research sponsored by the American Association of State Highway and Transportation Officials in cooperation with the Federal Highway Administration."