The publication is the fourth in a series intended to be a useful current-awareness tool for scientists but does not represent a verification of an author's recommended use of a particular species as a model, or as the best model, for a specific biologic process. The publication serves as a vehicle through which current research utilizing animal models can be compiled and disseminated periodically for evaluation. All entries are either authors' abstracts or their summaries and conclusions. Selected Abstracts on Animal Models for Biomedical Research is a publication of the Animal Models and Genetic Stocks Program, an information-exchange service conducted by ILAR. The program informs the biomedical community of the various animal models available and assists investigators in selecting and locating particular strains or stocks.

The collection of systems represented in Sourcebook of genomic programs, although this work is certainly well Models for Biomedical Research is an effort to re?ect the represented and indexed. diversity and utility of models that are used in biomedicine. Some models have been omitted due to page limitations That utility is based on the consideration that observations and we have encouraged the authors to use tables and made in particular organisms will provide insight into the ? gures to make comparisons of models so that observations workings of other, more complex, systems. Even the cell not available in primary publications can become useful to cycle in the simple yeast cell has similarities to that in the reader. humans and regulation with similar proteins occurs. We thank Richard Lansing and the staff at Humana for Some models have the advantage that the reproductive, guidance through the publication process. mitotic, development or aging cycles are rapid compared As this book was entering production, we learned of the with those in humans; others are utilized because individual loss of Tom Lanigan, Sr. Tom was a leader and innovator proteins may be studied in an advantageous way and that in scienti?c publishing and a good friend and colleague to have human homologs. Other organisms are facile to grow all in the exploratory enterprise. We dedicate this book to in laboratory settings or lend themselves to convenient analy- his memory. We will miss him greatly.