Did you know that Pocahontas probably never fell in love with John Smith, as the Disney and other film versions of those events pretend? That Godzilla was originally an anti-American and anti-nuclear movie, heavily cut and supplemented with new material? That Zorro was not created by an American author but derived from the much older Mexican struggle for independence? That Anna and the King was largely invented? That the myth of the sexually eager Hula girls is based on misunderstandings by the first explorers? That Black Hawk Down and many other war movies were censored and indirectly subsidized by the Pentagon? Screening Difference takes us on a fascinating voyage through major movie blockbusters that deal with the encounter between "us," based on white Hollywood, and "them," the filmic representations of other races, ethnicities, and cultures. Looking at subtle orientations in casting and make-up, sets and props, lighting and camera movements, music and language, this lively book follows the best-known genres and subgenres: from animated cartoons to wilderness films, from romantic movies to colonial adventures. Screening Difference tracks the stories back to their origins and patiently dissects the hidden messages that have gradually crept into them.

Screening programmes involve the systematic offer of testing for populations or groups of apparently healthy people to identify individuals who may be at future risk of a particular medical condition or disease, with the aim of offering intervention to reduce their risk. For many years, screening was practised without debate, and without evidence, but in the 1960s serious challenges were raised about many of the screening procedures then being practised. Benefits and harms of screening must be measured in high quality trials, and the benefits of screening must be weighed alongside the negative side-effects. Concerns were raised about potential and actual harm arising when people without a health problem received dangerous and unnecessary investigations and treatments as a result of routine screening tests. Controversy raged, and it took some 50 years to achieve widespread recognition that evidence-based and quality assured programme delivery was essential, coupled with provision of balanced informed to enable informed choice for potential participants. Commercially motivated provision of poor quality and non-evidence based screening tests is increasing and screening remains a highly contested topic that has relevance in all health systems including for the general public and media. This book serves as a practical and comprehensive guide to all aspects of screening. Following the international success of the first edition, this second edition brings extensive updates and new case study material. The first section deals with concepts, methods, and evidence, charts the story of screening back to 1861, and covers all aspects of a screening programme and how to research the full consequences. The second section is a practical guide to sound policy-making and to high quality delivery of best value screening. The controversies, paradoxes, uncertainties, and ethical dilemmas of screening are explained, and each chapter is packed with examples, real-life case histories, helpful summary points, and self-test questions. Reference is made to the NHS, a leader in screening, but the primary focus is on universal principles, making the book highly relevant across the globe.

This concise, self-contained and cohesive book focuses on commonly used and recently developed methods for designing and analyzing high-throughput screening (HTS) experiments from a statistically sound basis. Combining ideas from biology, computing and statistics, the author explains experimental designs and analytic methods that are amenable to rigorous analysis and interpretation of RNAi HTS experiments. The opening chapters are carefully presented to be accessible both to biologists with training only in basic statistics and to computational scientists and statisticians with basic biological knowledge. Biologists will see how new experiment designs and rudimentary data-handling strategies for RNAi HTS experiments can improve their results, whereas analysts will learn how to apply recently developed statistical methods to interpret HTS experiments.

Screening for Good Health is a practical guide to help you make sense of the hundreds of health messages that we are bombarded with each year. Whether or not there is a family history of a particular illness, screening and immunisation are smart, simple steps anyone can take to counter preventable diseases. Prepared by experts in their field, Screening for Good Health gives an overview of the stages in life, the screening tests and immunisations that are relevant to each age bracket, and the importance of your own record-keeping. An alphabetical listing covers every illness from Alzheimer’s Disease through to Osteoporosis to Tuberculosis. For each preventable illness, the entry provides up-to-date information on: - its symptoms - risk factors - disease progression - protective lifestyle choices an individual may consider - the screening tests available - the health services at your disposal, and - the treatment available. Also included is a comprehensive travel health section, with a convenient checklist covering all aspects of health protection during travel, and a first-aid guide.

This work provides a thought-provoking account of how medical treatments can be tested with unbiased or 'fair' trials and explains how patients can work with doctors to achieve this vital goal. It spans the gamut of therapy from mastectomy to thalidomide and explores a vast range of case studies.

Preventive services are an important facet of primary and specialty care. Screening stragegies, however, are sometimes complex or controversial. Busy clinicians need to know quickly the evidence base for the efficacy of these screening and preventive interventions. This book provides this information and relevant background data, discussing screening for often encountered diseases and condtions.