The number of diagnosed cases of primary immunodeficiency diseases (PIDs) – a group of inborn disorders of the immune system – is growing rapidly, but misdiagnosis or late diagnosis still occurs in a significant number of patients, with serious consequences. This is the second edition of a practical reference textbook on PIDs that has been widely welcomed by scientists and clinicians from around the world. The new edition has been extensively revised to reflect advances in knowledge and includes various PIDs not previously covered. For each disease, information is provided on definition, etiology, clinical manifestations, diagnosis, and management. This book will represent an ideal resource for specialists when engaging in diagnosis, clinical decision-making, and treatment planning. It will also prove invaluable for doctors in training and other physicians and nurses who wish to learn more about PIDs.

After a long time of neglect, Artificial Intelligence is once again at the center of most of our political, economic, and socio-cultural debates. Recent advances in the field of Artifical Neural Networks have led to a renaissance of dystopian and utopian speculations on an AI-rendered future. Algorithmic technologies are deployed for identifying potential terrorists through vast surveillance networks, for producing sentencing guidelines and recidivism risk profiles in criminal justice systems, for demographic and psychographic targeting of bodies for advertising or propaganda, and more generally for automating the analysis of language, text, and images. Against this background, the aim of this book is to discuss the heterogenous conditions, implications, and effects of modern AI and Internet technologies in terms of their political dimension: What does it mean to critically investigate efforts of net politics in the age of machine learning algorithms?

What are the most popular names of the Ambo people in Namibia? Why do so many Ambos have Finnish first names? What do the African names of these people mean? Why is the namesake so important in Ambo culture? How did the long independence struggle affect personal naming, and what are the latest name-giving trends in Namibia? This study analyses the changes in the personal naming system of the Ambo people in Namibia over the last 120 years, starting from the year 1883 when the first Ambos received biblical and European names at baptism. The central factors in this process were the German and South African colonisation and European missionary work on the one hand, and the rise of African nationalism on the other hand. Eventually, this clash between African and European naming practices led to a new and dynamic naming system which includes elements of both African and European origin.

Today our fatigue feels chronic; our anxieties, amplified. Proliferating technologies command our attention. Many people complain of burnout, and economic instability and the threat of ecological catastrophe fill us with dread. We look to the past, imagining life to have once been simpler and slower, but extreme mental and physical stress is not a modern syndrome. Beginning in classical antiquity, this book demonstrates how exhaustion has always been with us and helps us evaluate more critically the narratives we tell ourselves about the phenomenon. Medical, cultural, literary, and biographical sources have cast exhaustion as a biochemical imbalance, a somatic ailment, a viral disease, and a spiritual failing. It has been linked to loss, the alignment of the planets, a perverse desire for death, and social and economic disruption. Pathologized, demonized, sexualized, and even weaponized, exhaustion unites the mind with the body and society in such a way that we attach larger questions of agency, willpower, and well-being to its symptoms. Mapping these political, ideological, and creative currents across centuries of human development, Exhaustion finds in our struggle to overcome weariness a more significant effort to master ourselves.

A bold vision of liberal humanism for navigating today’s complex world of growing identity politics and rising nationalism Collective identities such as race, nationality, religion, gender, and sexuality clamor for recognition and respect, sometimes at the expense of other things we value. To what extent do they constrain our freedom, and to what extent do they enable our individuality? Is diversity of value in itself? Has the rhetoric of human rights been overstretched? Kwame Anthony Appiah draws on thinkers through the ages and across the globe to explore such questions, developing an account of ethics that connects moral obligations with collective allegiances and that takes aim at clichés and received ideas about identity. This classic book takes seriously both the claims of individuality—the task of making a life—and the claims of identity, these large and often abstract social categories through which we define ourselves.

This is really two books in one: a valuable reference resource, and a groundbreaking case study that represents a new approach to constructional semantics. It presents a detailed descriptive survey, using extensive examples collected from the Internet, of German verb constructions in which the expressions durch ('through'), über ('over'), unter ('under'), and um ('around') occur either as inseparable verb prefixes or as separable verb particles. Based on that evidence, the author argues that the prefixed verb constructions and particle verb constructions themselves have meaning, and that this meaning involves subjective construal processes rather than objective information. The constructions prompt us to distribute focal attention according to patterns that can be articulated in terms of Talmy's notion of “perspectival modes”. Among the other topics that play an important role in the analysis are incremental themes, reflexive trajectors, fictive motion, “multi-directional paths”, and “accusative landmarks”.