Advances in the Biosciences 5: Schering Workshop on Pharmacokinetics, Berlin, May 8 and 9, 1969 is a collection of papers presented at the Schering Workshop on Pharmacokinetics held in Berlin, Germany, on May 8 and 9, 1969. Contributors focus on advances in the field of pharmacokinetics, including the use of digital computers in defining pharmacokinetic parameters and of mathematical models in the study of steroid dynamics. The pharmacokinetics of acetazolamide and endogenous substances is also described. This book is comprised of 19 chapters and begins with an overview of the basic concepts and experimental methods of pharmacokinetics, followed by a discussion on the general physico-chemical aspects of drug distribution. Subsequent chapters explore multiple dose elimination kinetics and drug accumulation in patients with normal and impaired kidney function; the application of analog and digital computers in pharmacokinetics; use of mathematical tools in defining pharmacokinetic parameters; and measurement of enteric absorption rate using a double tracer technique. Mathematical and statistical problems in pharmacokinetics are also presented. This monograph will be a useful resource for pharmacologists and biologists.

First multi-year cumulation covers six years: 1965-70.

Advances in the Biosciences 8 is a collection of papers presented in a workshop on "Mechanisms and Prospects of Genetic Exchange, sponsored by Schering Pharma AG, held in Berlin, Germany in 1972. The book presents various research works from various scientific disciplines in line with the workshop's theme. The workshop is organized into 3 sessions. Session I: Genetic Exchange at the Molecular Level discusses such topics as enzymology of genetic recombination; studies on transcription and ligation of RNA; and expression and integration of viral DNA in animal cells. Session II: Genetic Exchange at the Cellular and Organelle Level covers topics on germinal cell membranes; application of cell fusion techniques to the study of mammalian embryology; and correction of genetic defects in cultured mammalian cells. The last session, titled "Present and Future Application to Medical Practice provides the summary and conclusion of the workshop and certain topics on the therapy of genetic diseases in man and the possible place of genetic engineering; and cellular engineering as an approach to the treatment of genetically determined disease. Molecular biologists, geneticists, cell biologists, biophysicists, immunologists and other experts in allied fields will find the compendium interesting.