Offers timely and comprehensive coverage of dynamic system reliability theory This book focuses on hot issues of dynamic system reliability, systematically introducing the reliability modeling and analysis methods for systems with imperfect fault coverage, systems with function dependence, systems subject to deterministic or probabilistic common-cause failures, systems subject to deterministic or probabilistic competing failures, and dynamic standby sparing systems. It presents recent developments of such extensions involving reliability modelling theory, reliability evaluation methods, and features numerous case studies based on real-world examples. The presented dynamic reliability theory can enable a more accurate representation of actual complex system behavior, thus more effectively guiding the reliable design of real-world critical systems. Dynamic System Reliability: Modelling and Analysis of Dynamic and Dependent Behaviors begins by describing the evolution from the traditional static reliability theory to the dynamic system reliability theory, and provides a detailed investigation of dynamic and dependent behaviors in subsequent chapters. Although written for those with a background in basic probability theory and stochastic processes, the book includes a chapter reviewing the fundamentals that readers need to know in order to understand contents of other chapters which cover advanced topics in reliability theory and case studies. The first book systematically focusing on dynamic system reliability modelling and analysis theory Provides a comprehensive treatment on imperfect fault coverage (single-level/multi-level or modular), function dependence, common cause failures (deterministic and probabilistic), competing failures (deterministic and probabilistic), and dynamic standby sparing Includes abundant illustrative examples and case studies based on real-world systems Covers recent advances in combinatorial models and algorithms for dynamic system reliability analysis Offers a rich set of references, providing helpful resources for readers to pursue further research and study of the topics Dynamic System Reliability: Modelling and Analysis of Dynamic and Dependent Behaviors is an excellent book for undergraduate and graduate students, and engineers and researchers in reliability and related disciplines.

Experimental chemotherapy continues to be at the forefront of cancer thera peutics. Topics covered in the preceding volume on cancer chemotherapy in this series such as study of drugs by alkaline elution, the development of the antimetabolite tiazofurin, and the treatment of germ cell tumors have become informative references to current experimentalists and practitioners. In even earlier volumes, reviews of the platinum compounds, anthracyclines, and osteosarcoma represent topics associated with such rapid progress requiring a look back to provide the appropriate perspective. Similarly, we venture to predict that the topics in this volume will become useful landmarks for future drug development and disease strategies. In the area of drug development, what is being learned about old, estab lished antineoplastics is raising renewed expectations that it will be translated into improved applications and patient benefit. For example, we now have the ability to modulate the action of alkylating agents and fluorinated pyri midines to achieve greater sensitivity. A new compound for an old target, trimetrexate, an antifolate that does not polyglutaminate, will have a role not only in treatment of neoplastic diseases, but also protozoal infection.

A must-have reference for any researcher or scientist interested in cutaneous protective mechanisms, this guide provides expertly researched chapters on every aspect of stratum corneum structure, function, and development, as well as detailed sections on barrier-repair strategies and the role of barrier function in diseases such as atopic dermatiti