Over the past two decades bioscience facilities worldwide have experienced multiple safety and security incidents, including many notable incidents at so-called sophisticated facilities in North America and Western Europe. This demonstrates that a system based solely on biosafety levels and security regulations may not be sufficient. Setting the stage for a substantively different approach for managing the risks of working with biological agents in laboratories, Laboratory Biorisk Management: Biosafety and Biosecurity introduces the concept of biorisk management--a new paradigm that encompasses both laboratory biosafety and biosecurity. The book also provides laboratory managers and directors with the information and technical tools needed for its implementation. The basis for this new paradigm is a three-pronged, multi-disciplinary model of assessment, mitigation, and performance (the AMP model). The application of the methodologies, criteria, and guidance outlined in the book helps to reduce the risk of laboratories becoming the sources of infectious disease outbreaks. This is a valuable resource for those seeking to embrace and implement biorisk management systems in their facilities and operations, including the biological research, clinical diagnostic, and production/manufacturing communities.

This handbook serves as a guide to deploying battery energy storage technologies, specifically for distributed energy resources and flexibility resources. Battery energy storage technology is the most promising, rapidly developed technology as it provides higher efficiency and ease of control. With energy transition through decarbonization and decentralization, energy storage plays a significant role to enhance grid efficiency by alleviating volatility from demand and supply. Energy storage also contributes to the grid integration of renewable energy and promotion of microgrid.

Biotechnology for Biofuel Production and Optimization is the compilation of current research findings that cover the entire process of biofuels production from manipulation of genes and pathways to organisms and renewable feedstocks for efficient biofuel production as well as different cultivation techniques and process scale-up considerations. This book captures recent breakthroughs in the interdisciplinary areas of systems and synthetic biology, metabolic engineering, and bioprocess engineering for renewable, cleaner sources of energy. - Describes state-of-the-art engineering of metabolic pathways for the production of a variety of fuel molecules - Discusses recent advances in synthetic biology and metabolic engineering for rational design, construction, evaluation of novel pathways and cell chassis - Covers genome engineering technologies to address complex biofuel-tolerant phenotypes for enhanced biofuel production in engineered chassis - Presents the use of novel microorganisms and expanded substrate utilization strategies for production of targeted fuel molecules - Explores biohybrid methods for harvesting bioenergy - Discusses bioreactor design and optimization of scale-up

This book presents a history of shock compression science, including development of experimental, material modeling, and hydrodynamics code technologies over the past six decades at Sandia National Laboratories. The book is organized into a discussion of major accomplishments by decade with over 900 references, followed by a unique collection of 45 personal recollections detailing the trials, tribulations, and successes of building a world-class organization in the field. It explains some of the challenges researchers faced and the gratification they experienced when a discovery was made. Several visionary researchers made pioneering advances that integrated these three technologies into a cohesive capability to solve complex scientific and engineering problems. What approaches worked, which ones did not, and the applications of the research are described. Notable applications include the turret explosion aboard the USS Iowa and the Shoemaker-Levy comet impact on Jupiter. The personal anecdotes and recollections make for a fascinating account of building a world-renowned capability from meager beginnings. This book will be inspiring to the expert, the non expert, and the early-career scientist. Undergraduate and graduate students in science and engineering who are contemplating different fields of study should find it especially compelling.

In this work, the unique power measurement capabilities of the Cray XT architecture were exploited to gain an understanding of power and energy use, and the effects of tuning both CPU and network bandwidth. Modifications were made to deterministically halt cores when idle. Additionally, capabilities were added to alter operating P-state. At the application level, an understanding of the power requirements of a range of important DOE/NNSA production scientific computing applications running at large scale is gained by simultaneously collecting current and voltage measurements on the hosting nodes. The effects of both CPU and network bandwidth tuning are examined, and energy savings opportunities without impact on run-time performance are demonstrated. This research suggests that next-generation large-scale platforms should not only approach CPU frequency scaling differently, but could also benefit from the capability to tune other platform components to achieve more energy-efficient performance.

State-of-the-Art Software Security Testing: Expert, Up to Date, and Comprehensive The Art of Software Security Testing delivers in-depth, up-to-date, battle-tested techniques for anticipating and identifying software security problems before the “bad guys” do. Drawing on decades of experience in application and penetration testing, this book’s authors can help you transform your approach from mere “verification” to proactive “attack.” The authors begin by systematically reviewing the design and coding vulnerabilities that can arise in software, and offering realistic guidance in avoiding them. Next, they show you ways to customize software debugging tools to test the unique aspects of any program and then analyze the results to identify exploitable vulnerabilities. Coverage includes Tips on how to think the way software attackers think to strengthen your defense strategy Cost-effectively integrating security testing into your development lifecycle Using threat modeling to prioritize testing based on your top areas of risk Building testing labs for performing white-, grey-, and black-box software testing Choosing and using the right tools for each testing project Executing today’s leading attacks, from fault injection to buffer overflows Determining which flaws are most likely to be exploited by real-world attackers