Summary Rx.NET in Action teaches developers how to build event-driven applications using the Reactive Extensions (Rx) library. Purchase of the print book includes a free eBook in PDF, Kindle, and ePub formats from Manning Publications. About the Technology Modern applications must react to streams of data such as user and system events, internal messages, and sensor input. Reactive Extensions (Rx) is a .NET library containing more than 600 operators that you can compose together to build reactive client- and server-side applications to handle events asynchronously in a way that maximizes responsiveness, resiliency, and elasticity. About the Book Rx.NET in Action teaches developers how to build event-driven applications using the Rx library. Starting with an overview of the design and architecture of Rx-based reactive applications, you'll get hands-on with in-depth code examples to discover firsthand how to exploit the rich query capabilities that Rx provides and the Rx concurrency model that allows you to control both the asynchronicity of your code and the processing of event handlers. You'll also learn about consuming event streams, using schedulers to manage time, and working with Rx operators to filter, transform, and group events. What's Inside Introduction to Rx in C# Creating and consuming streams of data and events Building complex queries on event streams Error handling and testing Rx code About the Reader Readers should understand OOP concepts and be comfortable coding in C#. About the Author Tamir Dresher is a senior software architect at CodeValue and a prominent member of Israel's Microsoft programming community. Table of Contents PART 1 - GETTING STARTED WITH REACTIVE EXTENSIONS Reactive programming Hello, Rx Functional thinking in C# PART 2 - CORE IDEAS Creating observable sequences Creating observables from .NET asynchronous types Controlling the observer-observable relationship Controlling the observable temperature Working with basic query operators Partitioning and combining observables Working with Rx concurrency and synchronization Error handling and recovery APPENDIXES Writing asynchronous code in .NET The Rx Disposables library Testing Rx queries and operators

Summary .NET Core in Action shows .NET developers how to build professional software applications with .NET Core. Learn how to convert existing .NET code to work on multiple platforms or how to start new projects with knowledge of the tools and capabilities of .NET Core. Purchase of the print book includes a free eBook in PDF, Kindle, and ePub formats from Manning Publications. About the Technology .NET Core is an open source framework that lets you write and run .NET applications on Linux and Mac, without giving up on Windows. Built for everything from lightweight web apps to industrial-strength distributed systems, it's perfect for deploying .NET servers to any cloud platform, including AWS and GCP. About the Book .NET Core in Action introduces you to cross-platform development with .NET Core. This hands-on guide concentrates on new Core features as you walk through familiar tasks like testing, logging, data access, and networking. As you go, you'll explore modern architectures like microservices and cloud data storage, along with practical matters like performance profi ling, localization, and signing assemblies. What's Inside Choosing the right tools Testing, profiling, and debugging Interacting with web services Converting existing projects to .NET Core Creating and using NuGet packages About the Reader All examples are in C#. About the Author Dustin Metzgar is a seasoned developer and architect involved in numerous .NET Core projects. Dustin works for Microsoft. Table of Contents Why .NET Core? Building your first .NET Core applications How to build with .NET Core Unit testing with xUnit Working with relational databases Simplify data access with object-relational mappers Creating a microservice Debugging Performance and profiling Building world-ready applications Multiple frameworks and runtimes Preparing for release appendix A - Frameworks and runtimes appendix B - xUnit command-line options appendix C - What's in the .NET Standard Library? appendix D - NuGet cache locations

Systematically examining current methods and strategies, this ready reference covers a wide range of molecular structures, from organic-chemical drugs to peptides, Proteins and nucleic acids, in line with emerging new drug classes derived from biomacromolecules. A leader in the field and one of the pioneers of this young discipline has assembled here the most prominent experts from across the world to provide first-hand knowledge. While most of their methods and examples come from the area of pharmaceutical discovery and development, the approaches are equally applicable for chemical probes and diagnostics, pesticides, and any other molecule designed to interact with a biological system. Numerous images and screenshots illustrate the many examples and method descriptions. With its broad and balanced coverage, this will be the firststop resource not only for medicinal chemists, biochemists and biotechnologists, but equally for bioinformaticians and molecular designers for many years to come. From the content: * Reaction-driven de novo design * Adaptive methods in molecular design * Design of ligands against multitarget profiles * Free energy methods in ligand design * Fragment-based de novo design * Automated design of focused and target family-oriented compound libraries * Molecular de novo design by nature-inspired computing * 3D QSAR approaches to de novo drug design * Bioisosteres in de novo design * De novo design of peptides, proteins and nucleic acid structures, including RNA aptamers and many more.

Summary RxJS in Action gives you the development skills you need to create reactive applications with RxJS. This book is full of theory and practical examples that build on each other and help you begin thinking in a reactive manner. Foreword by Ben Lesh, Project lead, RxJS 5. Purchase of the print book includes a free eBook in PDF, Kindle, and ePub formats from Manning Publications. About the Technology On the web, events and messages flow constantly between UI and server components. With RxJS, you can filter, merge, and transform these streams directly, opening the world of data flow programming to browser-based apps. This JavaScript implementation of the ReactiveX spec is perfect for on-the-fly tasks like autocomplete. Its asynchronous communication model makes concurrency much, much easier. About the Book RxJS in Action is your guide to building a reactive web UI using RxJS. You'll begin with an intro to stream-based programming as you explore the power of RxJS through practical examples. With the core concepts in hand, you'll tackle production techniques like error handling, unit testing, and interacting with frameworks like React and Redux. And because RxJS builds on ideas from the world of functional programming, you'll even pick up some key FP concepts along the way. What's Inside Building clean, declarative, fault-tolerant applications Transforming and composing streams Taming asynchronous processes Integrating streams with third-party libraries Covers RxJS 5 About the Reader This book is suitable for readers comfortable with JavaScript and standard web application architectures. About the Author Paul P. Daniels is a professional software engineer with experience in .NET, Java, and JavaScript. Luis Atencio is a software engineer working daily with Java, PHP, and JavaScript platforms, and author of Manning's Functional Programming in JavaScript. Table of Contents PART 1 - UNDERSTANDING STREAMS Thinking reactively Reacting with RxJS Core operators It's about time you used RxJS PART 2 - OBSERVABLES IN PRACTICE Applied reactive streams Coordinating business processes Error handling with RxJS PART 3 MASTERING RXJS Heating up observables Toward testable, reactive programs RxJS in the wild

Summary Dependency Injection Principles, Practices, and Patterns teaches you to use DI to reduce hard-coded dependencies between application components. You'll start by learning what DI is and what types of applications will benefit from it. Then, you'll work through concrete scenarios using C# and the .NET framework to implement DI in your own projects. As you dive into the thoroughly-explained examples, you'll develop a foundation you can apply to any of the many DI libraries for .NET and .NET Core. Purchase of the print book includes a free eBook in PDF, Kindle, and ePub formats from Manning Publications. About the Technology Dependency Injection (DI) is a great way to reduce tight coupling between software components. Instead of hard-coding dependencies, such as specifying a database driver, you make those connections through a third party. Central to application frameworks like ASP.NET Core, DI enables you to better manage changes and other complexity in your software. About the Book Dependency Injection Principles, Practices, and Patterns is a revised and expanded edition of the bestselling classic Dependency Injection in .NET. It teaches you DI from the ground up, featuring relevant examples, patterns, and anti-patterns for creating loosely coupled, well-structured applications. The well-annotated code and diagrams use C# examples to illustrate principles that work flawlessly with modern object-oriented languages and DI libraries. What's Inside Refactoring existing code into loosely coupled code DI techniques that work with statically typed OO languages Integration with common .NET frameworks Updated examples illustrating DI in .NET Core About the Reader For intermediate OO developers. About the Authors Mark Seemann is a programmer, software architect, and speaker who has been working with software since 1995, including six years with Microsoft. Steven van Deursen is a seasoned .NET developer and architect, and the author and maintainer of the Simple Injector DI library. Table of Contents PART 1 Putting Dependency Injection on the map The basics of Dependency Injection: What, why, and how Writing tightly coupled code Writing loosely coupled code PART 2 Catalog DI patterns DI anti-patterns Code smells PART 3 Pure DI Application composition Object lifetime Interception Aspect-Oriented Programming by design Tool-based Aspect-Oriented Programming PART 4 DI Containers DI Container introduction The Autofac DI Container The Simple Injector DI Container The Microsoft.Extensions.DependencyInjection DI Container

Summary Concurrency in .NET teaches you how to build concurrent and scalable programs in .NET using the functional paradigm. This intermediate-level guide is aimed at developers, architects, and passionate computer programmers who are interested in writing code with improved speed and effectiveness by adopting a declarative and pain-free programming style. Purchase of the print book includes a free eBook in PDF, Kindle, and ePub formats from Manning Publications. About the Technology Unlock the incredible performance built into your multi-processor machines. Concurrent applications run faster because they spread work across processor cores, performing several tasks at the same time. Modern tools and techniques on the .NET platform, including parallel LINQ, functional programming, asynchronous programming, and the Task Parallel Library, offer powerful alternatives to traditional thread-based concurrency. About the Book Concurrency in .NET teaches you to write code that delivers the speed you need for performance-sensitive applications. Featuring examples in both C# and F#, this book guides you through concurrent and parallel designs that emphasize functional programming in theory and practice. You'll start with the foundations of concurrency and master essential techniques and design practices to optimize code running on modern multiprocessor systems. What's Inside The most important concurrency abstractions Employing the agent programming model Implementing real-time event-stream processing Executing unbounded asynchronous operations Best concurrent practices and patterns that apply to all platforms About the Reader For readers skilled with C# or F#. About the Book Riccardo Terrell is a seasoned software engineer and Microsoft MVP who is passionate about functional programming. He has over 20 years' experience delivering cost-effective technology solutions in a competitive business environment. Table of Contents PART 1 - Benefits of functional programming applicable to concurrent programs Functional concurrency foundations Functional programming techniques for concurrency Functional data structures and immutability PART 2 - How to approach the different parts of a concurrent program The basics of processing big data: data parallelism, part 1 PLINQ and MapReduce: data parallelism, part 2 Real-time event streams: functional reactive programming Task-based functional parallelism Task asynchronicity for the win Asynchronous functional programming in F# Functional combinators for fluent concurrent programming Applying reactive programming everywhere with agents Parallel workflow and agent programming with TPL Dataflow PART 3 - Modern patterns of concurrent programming applied Recipes and design patterns for successful concurrent programming Building a scalable mobile app with concurrent functional programming

Microservices in .NET Core, Second Edition is a comprehensive guide to building microservice applications using the .NET stack. After a crystal-clear introduction to the microservices architectural style, it teaches you practical microservices development skills using MVC Core and ASP.NET Core. This second edition of the bestselling original has been revised with up-to-date tools for the .NET ecosystem, and more new coverage of scoping microservices and deploying to Kubernetes. about the technology Microservice applications are built by connecting single-capability, autonomous components that communicate via APIs. Microservice architectures boost productivity, support Agile workflows, and decrease the risks of catastrophic failures. However, they can be a big challenge to develop, as they demand clearly defined interfaces and reliable infrastructure. Luckily for developers, Microsoft''s own MVC Core and ASP.NET Core frameworks help manage the tricky API and simplify the task of building microservice-based applications. about the book Microservices in .NET Core, Second Edition provides a complete guide to building microservice applications. You''ll start by getting to grips with the unique architectural style of microservices, explained in a way that''s clear and accessible. You''ll move on quickly to practical development skills for building your own microservices using MVC Core and ASP.NET Core, working on real-world projects such as an ecommerce shopping cart. You''ll design and build individual services in C# and learn how to compose them into a simple but functional application back end. In brand-new coverage for the second edition, you''ll also learn about scoping microservices and how to handle the complexities of deploying to Kubernetes. Along the way, you''ll address production and operations concerns like monitoring, logging, and security. what''s inside Build scalable microservices that are reliable in production Optimized microservices for continuous delivery Design event-based collaboration between microservices Deploy microservices to Kubernetes Set up Kubernetes in Azure about the reader This book is written for C# developers. No previous experience with microservices required. about the author Christian Horsdal is an independent consultant with 20 years of experience building systems from large scale microservice systems to tiny embedded systems--and lots of stuff in between. He is a .NET expert, author of the books Microservices in .NET Core and Instant Nancy Web Development, a trainer, and an occasional open source contributor.