RNA Folding

RNA Folding
Title RNA Folding PDF eBook
Author Christina Waldsich
Publisher Humana
Pages 0
Release 2016-08-23
Genre Medical
ISBN 9781493960583

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Focusing on in vitro and intracellular RNA structure formation, RNA Folding: Methods and Protocols provides a comprehensive collection of experimental protocols which are suitable to dissect RNA folding pathways and to characterize the structure of RNA folding intermediates at nucleotide or even atomic resolution. The presented techniques include powerful tools with a long tradition in RNA research as well as more advanced, novel methods, thus the methods span multiple disciplines, including molecular biology, biochemistry, biophysics, and computational biology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and authoritative, RNA Folding: Methods and Protocols serves as a vital reference for researchers attempting to gain insights into the secrets of this astounding macromolecule.

RNA Folding

RNA Folding
Title RNA Folding PDF eBook
Author Ronny Lorenz
Publisher Springer Nature
Pages 407
Release
Genre
ISBN 1071635190

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Biophysics of RNA Folding

Biophysics of RNA Folding
Title Biophysics of RNA Folding PDF eBook
Author Rick Russell
Publisher Springer Science & Business Media
Pages 238
Release 2012-12-09
Genre Science
ISBN 1461449545

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This volume, written by experts in the field, discusses the current understanding of the biophysical principles that govern RNA folding, with featured RNAs including the ribosomal RNAs, viral RNAs, and self-splicing introns. In addition to the fundamental features of RNA folding, the central experimental and computational approaches in the field are presented with an emphasis on their individual strengths and limitations, and how they can be combined to be more powerful than any method alone; these approaches include NMR, single molecule fluorescence, site-directed spin labeling, structure mapping, comparative sequence analysis, graph theory, course-grained 3D modeling, and more. This volume will be of interest to professional researchers and advanced students entering the field of RNA folding.

RNA Structure Determination

RNA Structure Determination
Title RNA Structure Determination PDF eBook
Author Douglas H. Turner
Publisher Humana
Pages 0
Release 2016-09-24
Genre Medical
ISBN 9781493964314

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This volume provides protocols and procedures for determining and modeling RNA structure. Chapters guide the reader through protocols for RNA secondary structure prediction, single sequence modeling, Crumple, RNAstructure to model conserved secondary structures with multiple homologs, the prediction of bimolecular secondary structures with RNAstructure, STarMir, protocols for structure mapping, mapping data to constrain or restrain RNA secondary structure prediction with RNAstructure, unassigned NMR resonances, modeling protocols for Rosetta FARFAR, RNAComposer , ModeRNA, and MC-Fold. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and Practical, RNA Structure Determination: Methods and Protocols aims to ensure successful results in the further study of this vital field.

RNA 3D Structure Analysis and Prediction

RNA 3D Structure Analysis and Prediction
Title RNA 3D Structure Analysis and Prediction PDF eBook
Author Neocles Leontis
Publisher Springer Science & Business Media
Pages 402
Release 2012-06-05
Genre Science
ISBN 3642257402

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With the dramatic increase in RNA 3D structure determination in recent years, we now know that RNA molecules are highly structured. Moreover, knowledge of RNA 3D structures has proven crucial for understanding in atomic detail how they carry out their biological functions. Because of the huge number of potentially important RNA molecules in biology, many more than can be studied experimentally, we need theoretical approaches for predicting 3D structures on the basis of sequences alone. This volume provides a comprehensive overview of current progress in the field by leading practitioners employing a variety of methods to model RNA 3D structures by homology, by fragment assembly, and by de novo energy and knowledge-based approaches.

RNA Design

RNA Design
Title RNA Design PDF eBook
Author Alexander Churkin
Publisher Springer Nature
Pages 306
Release
Genre
ISBN 1071640798

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Handbook of RNA Biochemistry

Handbook of RNA Biochemistry
Title Handbook of RNA Biochemistry PDF eBook
Author Roland K. Hartmann
Publisher John Wiley & Sons
Pages 1370
Release 2015-06-22
Genre Science
ISBN 3527327762

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The second edition of a highly acclaimed handbook and ready reference. Unmatched in its breadth and quality, around 100 specialists from all over the world share their up-to-date expertise and experiences, including hundreds of protocols, complete with explanations, and hitherto unpublished troubleshooting hints. They cover all modern techniques for the handling, analysis and modification of RNAs and their complexes with proteins. Throughout, they bear the practising bench scientist in mind, providing quick and reliable access to a plethora of solutions for practical questions of RNA research, ranging from simple to highly complex. This broad scope allows the treatment of specialized methods side by side with basic biochemical techniques, making the book a real treasure trove for every researcher experimenting with RNA.