With the odds and the evidence against them, Harry Bosch and Mickey Haller must nail a sadistic killer once and for all.

Why medicine adopts ineffective or harmful medical practices only to abandon them—sometimes too late. Medications such as Vioxx and procedures such as vertebroplasty for back pain are among the medical "advances" that turned out to be dangerous or useless. What Dr. Vinayak K. Prasad and Dr. Adam S. Cifu call medical reversal happens when doctors start using a medication, procedure, or diagnostic tool without a robust evidence base—and then stop using it when it is found not to help, or even to harm, patients. In Ending Medical Reversal, Drs. Prasad and Cifu narrate fascinating stories from every corner of medicine to explore why medical reversals occur, how they are harmful, and what can be done to avoid them. They explore the difference between medical innovations that improve care and those that only appear to be promising. They also outline a comprehensive plan to reform medical education, research funding and protocols, and the process for approving new drugs that will ensure that more of what gets done in doctors' offices and hospitals is truly effective.

A Financial Times Book of the Year A ProMarket Book of the Year “Superbly argued and important...Donald Trump is in so many ways a product of the defective capitalism described in The Great Reversal. What the U.S. needs, instead, is another Teddy Roosevelt and his energetic trust-busting. Is that still imaginable? All believers in the virtues of competitive capitalism must hope so.” —Martin Wolf, Financial Times “In one industry after another...a few companies have grown so large that they have the power to keep prices high and wages low. It’s great for those corporations—and bad for almost everyone else.” —David Leonhardt, New York Times “Argues that the United States has much to gain by reforming how domestic markets work but also much to regain—a vitality that has been lost since the Reagan years...His analysis points to one way of making America great again: restoring our free-market competitiveness.” —Arthur Herman, Wall Street Journal Why are cell-phone plans so much more expensive in the United States than in Europe? It seems a simple question, but the search for an answer took one of the world’s leading economists on an unexpected journey through some of the most hotly debated issues in his field. He reached a surprising conclusion: American markets, once a model for the world, are giving up on healthy competition. In the age of Silicon Valley start-ups and millennial millionaires, he hardly expected this. But the data from his cutting-edge research proved undeniable. In this compelling tale of economic detective work, we follow Thomas Philippon as he works out the facts and consequences of industry concentration, shows how lobbying and campaign contributions have defanged antitrust regulators, and considers what all this means. Philippon argues that many key problems of the American economy are due not to the flaws of capitalism or globalization but to the concentration of corporate power. By lobbying against competition, the biggest firms drive profits higher while depressing wages and limiting opportunities for investment, innovation, and growth. For the sake of ordinary Americans, he concludes, government needs to get back to what it once did best: keeping the playing field level for competition. It’s time to make American markets great—and free—again.

This original and panoramic book proposes that the underlying forces of demography and globalisation will shortly reverse three multi-decade global trends – it will raise inflation and interest rates, but lead to a pullback in inequality. “Whatever the future holds”, the authors argue, “it will be nothing like the past”. Deflationary headwinds over the last three decades have been primarily due to an enormous surge in the world’s available labour supply, owing to very favourable demographic trends and the entry of China and Eastern Europe into the world’s trading system. This book demonstrates how these demographic trends are on the point of reversing sharply, coinciding with a retreat from globalisation. The result? Ageing can be expected to raise inflation and interest rates, bringing a slew of problems for an over-indebted world economy, but is also anticipated to increase the share of labour, so that inequality falls. Covering many social and political factors, as well as those that are more purely macroeconomic, the authors address topics including ageing, dementia, inequality, populism, retirement and debt finance, among others. This book will be of interest and understandable to anyone with an interest on where the world’s economy may be going.

Not long ago, Republicans could take pride in their party’s tradition of environmental leadership. In the late 1960s and early 1970s, the GOP helped to create the Environmental Protection Agency, extend the Clean Air Act, and protect endangered species. Today, as Republicans denounce climate change as a “hoax” and seek to dismantle the environmental regulatory state they worked to build, we are left to wonder: What happened? In The Republican Reversal, James Morton Turner and Andrew C. Isenberg show that the party’s transformation began in the late 1970s, with the emergence of a new alliance of pro-business, libertarian, and anti-federalist voters. This coalition came about through a concerted effort by politicians and business leaders, abetted by intellectuals and policy experts, to link the commercial interests of big corporate donors with states’-rights activism and Main Street regulatory distrust. Fiscal conservatives embraced cost-benefit analysis to counter earlier models of environmental policy making, and business tycoons funded think tanks to denounce federal environmental regulation as economically harmful, constitutionally suspect, and unchristian, thereby appealing to evangelical views of man’s God-given dominion of the Earth. As Turner and Isenberg make clear, the conservative abdication of environmental concern stands out as one of the most profound turnabouts in modern American political history, critical to our understanding of the GOP’s modern success. The Republican reversal on the environment is emblematic of an unwavering faith in the market, skepticism of scientific and technocratic elites, and belief in American exceptionalism that have become the party’s distinguishing characteristics.

Defense attorney and Harvard law professor provides an insider's account of the trial, appeal, subsequent retrial, and acquittal in the murder case of Claus von Bulow, profiling the people involved. NOTE: This edition does not include photographs.

From childhood, Eileen Simpson grew up with a confusing and frustrating disorder. Simpson was 22 when her future husband, poet John Berryman, named her mysterious ailment--dyslexia, a neurophysical condition that causes some 23 million Americans to scramble words and letters into visual chaos. REVERSALS will provide inspiration and insight for those suffering from dyslexia, as well as for their parents, friends, and teachers.