Raccoon City: a remote mountain community suddenly besieged by a rash of grisly murders. At the epicenter, a dark secluded mansion belonging to the mysterious Umbrella Corporation. Deployed to investigate the strange goings-on is the Special Tactics and Rescue Squad (S.T.A.R.S.) but what unfolds as the team penetrate the mansion’s long-locked doors is terror beyond their worst nightmares.

Zombies, mutant animals, bioengineered weapons and surgically enhanced monsters: after all she’s been through, Jill Valentine is ready to leave Raccoon City for ever. But the Umbrella Corporation isn’t finished with Raccoon City. Under cover of night, mercenary teams have entered the city, along with something else - a lethal creature code-named Nemesis. Nemesis is on the hunt, and Jill is its prey.

Leon Kennedy, a rookie cop on a new assignment, and Claire Redfield, sister of the still-missing S.T.A.R.S. member Chris, arrive at Raccoon City to discover a necropolis. A botched attempt by the Umbrella Corporation to retrieve a devastating mutagenic weapon has resulted in a horrifying viral outbreak, transforming the city’s population into the living dead. And all of them are hungry.

Combat medic and biochemist Rebecca Chambers, the sole survivor of Bravo Team, joins a new S.T.A.R.S. strike force when rumor comes of another Umbrella experiment: hidden beneath the rocky cliffs of Caliban Cove, Maine, someone is building an army of the undead. Now the S.T.A.R.S. must battle more unspeakable horrors and stop a madman from unleashing the biohazard upon the world.

Beneath the deserts of the American Southwest, one of the Umbrella Corporation's most elaborate facilities is about to go online. Somewhere inside may also be the key to stopping Umbrella once and for all... can Leon Kennedy, Claire Redfield, Rebecca Chambers, and their friends can get past a strike team of corrupt S.T.A.R.S., and survive the genetically engineered horrors awaiting them?

A remote mountain community is suddenly beseiged by a rash of grisly murders encroaching upon it from the surrounding forest. Bizarre reports start to spread, describing attacks from viscious creatures, some human...some not. At the centre of these deaths is a dark, secluded mansion belonging to the mysterious Umbrella Corporation. For years Umbrella has laboured within the mansion, unwatched, ostensibly conducting benign genetic research. Deployed to investigate the strange goings on is the Special Tactics and Rescue Squad (S.T.A.R.S), a paramilitary response unit boasting an unusual array of mission specialists. They believe they are ready for anything but nothing prepares them for the terror which awaits them when they penetrate the mansions long-locked doors. Behind the horror of nightmare creatures, results of forbidden experiments gone disasterously wrong, lies a conspiracy so vast in its scope and so insidious in its agenda that the S.T.A.R.S will be betrayed from within to ensure that the world never learns Umbrella's secret. And if any survive...they may well come to envy those who do not.

The Umbrella Chronicles encompasses several scenarios, which are based on various plot elements from the Resident Evil series. The main characters include: Rebecca Chambers, Billy Coen, Chris Redfield, Jill Valentine, Carlos Oliveira, Albert Wesker, Ada Wong, Richard Aiken, and Hunk. The first scenario, based on the events of Resident Evil Zero, follows STARS operative Rebecca Chambers, and former Marine Billy Coen as they venture through a train that eventually takes them to a derelict training facility. Once within the facility, they discover they are being stalked by James Marcus, one of the Umbrella Corporation's co-founders and former scientists, who has managed to resurrect himself with the aid of leech test-subjects. After a confrontation, Marcus mutates into a monstrosity, but is subdued by the duo. Chambers and Coen escape as the facility self-destructs. Another sub-chapter within the scenario traces Wesker's actions, now posing as the leader of STARS' Alpha team, as he attempts to escape the training facility. This chapter also introduces Sergei Vladimir and one of his bodyguard Tyrants, codenamed "IVAN". The next scenario follows Chris Redfield and Jill Valentine, as opposed to the actual Resident Evil game, which features the two splitting up. Redfield and Valentine are forced to battle their way through a mansion full of undead residents before stumbling upon a secret Umbrella Corporation research facility in the mansion's basement. The two then discover the facility's most powerful creation, a Tyrant, and destroy it. The scenario features two different sub-chapters, which reveal Chambers' action between Resident Evil Zero and Resident Evil, as well as Wesker's reanimation and escape after his apparent death. The next scenario visits Raccoon City during the events of Resident Evil 3: Nemesis. Valentine returns to the game, and is paired with mercenary Carlos Oliveira, as they attempt to survive an outbreak of the T-virus. After defeating several undead citizens, Valentine and Oliveira encounter Nemesis, an upgraded Tyrant, sent to kill Valentine.[16] They defeat Nemesis and escape Raccoon City before it is destroyed by the United States government in a desperate contingency measure. The scenario also features two sub-chapters, detailing Ada Wong and Hunk's background roles during the main scenario's events. The game's final scenario is composed of new material, which trails Redfield and Valentine as they and other armed anti-bioweapon activists investigate the Umbrella Corporation's final stronghold in Russia. Now leading a group of armed activists, they storm the stronghold, encountering waves of undead soldiers and mutations. Despite their force sustaining heavy casualties, Redfield and Valentine enter the facility's inner sanctum, only to encounter and destroy the Umbrella Corporation's latest creation, the T-ALOS project. The game's final sub-chapter features Wesker infiltrating the facility in an attempt to recover the Umbrella Corporation's most important files. He is confronted by his long-time nemesis, Sergei Vladimir, whom he defeats. In the end, the Umbrella Corporation's secrets have finally been exposed. As a result, the U.S. government succeeds in its legal action against Umbrella's top officials.