All across the United States, individuals, families, communities, and health care systems are struggling to cope with substance use, misuse, and substance use disorders. Substance misuse and substance use disorders have devastating effects, disrupt the future plans of too many young people, and all too often, end lives prematurely and tragically. Substance misuse is a major public health challenge and a priority for our nation to address. The effects of substance use are cumulative and costly for our society, placing burdens on workplaces, the health care system, families, states, and communities. The Report discusses opportunities to bring substance use disorder treatment and mainstream health care systems into alignment so that they can address a person's overall health, rather than a substance misuse or a physical health condition alone or in isolation. It also provides suggestions and recommendations for action that everyone-individuals, families, community leaders, law enforcement, health care professionals, policymakers, and researchers-can take to prevent substance misuse and reduce its consequences.

This is the tenth volume in the Research Advances series and the seventh published by Plenum Press. Volume 10 is another omnibus volume, providing specialized and advanced reviews in a number of areas related to the use of alcohol, illicit drugs, and tobacco. We include also a brief history of the Center for Alcohol Studies that gives Mark Keller's unique perspective on this noted institution. Two of the chapters are decidedly longer than the others-very long chapters have appeared occasionally in the past, and we think that it is one of the strengths of the series that we are able to accommodate such reviews. Again the editorial board has changed. After several years of service, Reginald G. Smart has stepped down. New to the board are Helen M. Annis, Michael S. Goodstadt, Lynn T. Kozlowski, and Evelyn R. Vingilis. This is likely to be the sole volume for which Goodstadt is on the board, since before completion of this volume he moved from the Addiction Research Foundation to the Center for Alcohol Studies, Rutgers University.

This volume is the eighth in the Research Advances Series and the fifth published by Plenum Press. The purpose of the series is to review new work in rapidly changing fields. We do not expect reviews to cover the whole field of work on alcoholism and addiction. Nor do we expect that they will be like annual reviews covering all work in a delimited field. Our reviews are designed to explore only the most exciting parts of the total field and to focus on conclusions that can be made about them. The series publishes one volume each year. Volume 8 is an omnibus rather than a theme volume in that a wide range of topics is covered, including research on alcohol, opiates, and tobacco. As usual, the greater emphasis is on alcohol research, reflecting the importance of the problem and the volume of work to be reviewed. With Volume 8 come some changes in the Editorial Board. It will be the last volume in the series for Robert E. Popham who has resigned from the Board. He has been with the series since its inception and has contributed a great deal to its development. The members of the Board are grateful for his help. We are adding two new members: Dr. Howard Cappell, whose field is experimental psychology, and Dr. Edward M. Sellers, in clinical medicine and pharmacology.

This book continues the series of reviews of research advances first published in 1974. The editors' aim here is to present critical and integrative reviews by internationally recognized scholars of areas in which there has been much recent research. In this task we have been greatly helped by the staff of Plenum Press and the Advisory Panel listed at the front of this volume. Several members of the Panel have retired: Dr. W.M.D. Paton, Dr. K. Bruun, Dr. K.F. Killam, and Dr. J .R. Seeley. Dr. Klaus Makela has accepted our invitation to join the Panel. Unfortunately, one member of the Panel, Professor William McGlothlin, died as a result of a tragic accident. He was a gifted and sensitive researcher. His work over many years was well known to those studying alcohol and drug problems. We want to acknowledge his contributions to the Research Advances Series and to the field in general. The editors wish to acknowledge the help of Julliana Newell Ayoub in preparation of this volume. This volume contains three papers by H. Fingarette, R. Room, and B. Kissin, on "The Disease Concept." They were originally prepared for an earlier volume but could not be included because of scheduling problems. The editors, and not the authors, are responsible for this delay. Because they are primarily philosophical and theoretical in nature they are not diminished in value by the lesser number of references to recent research.

Disorders of anxiety and substance use are, for some reason, rarely treated in an integrated fashion by professionals. This timely volume addresses this glaring omission with dispatches from the frontlines of research and treatment. Thirty-four international experts offer findings, theories, and intervention strategies for this common form of dual disorder, across a range of substances and of anxiety disorders, to give the reader comprehensive knowledge in a practical format.