This issue provides a timely update for for the ob/gyn on genetics in reproductive medicine. Dr. Dugoff has created an issue with the goals of providing the most currently clinical information on genetic screening and prenatal genetics. Top authors have written reviews on the following topics: Genetic counseling overview for the ob/gyn; Cell-free DNA screening for aneuploidy; Cell-free DNA screening for single gene disorders; The use of microarray in prenatal diagnosis; Whole exome sequencing: Applications in prenatal diagnosis; Screening for aneuploidy in multiple gestations: The challenges and available options; Expanded carrier screening; Ethnicity-based carrier screening overview; Prenatal genetic diagnosis and prenatal genetic screening; Ethical issues in prenatal genetics; Ultrasound findings and associated genetic syndromes; Hereditary cancers in gynecology: and What physicians should know about genetic testing, screening and risk reduction. Readers will come away with the knowledge they need to diagnose, treat, and manage patients based on the most current evidence and data.

Genetic Screening and Counseling is reviewed in this issue of Obstetrics and Gynecology Clinics, guest edited by Drs. Anthony R. Gregg and Joe Leigh Simpson. Authorities in the field have come together to pen articles on Contemporary Genetics Counseling: New Frontiers and Challenges, Newborn Screening, SMA Carrier Screening, Fragile X, Ashkenazi Jewish Screening in the 21st Century, Thrombophilia in Obstetric Practice, Microarrays in the Practice of Obstetrics and Gynecology, Cancer Genetic Screening, and Cystic Fibrosis.

In consultation with Consulting Editor Dr. William Rayburn, Dr. Santor and Dr. Kravitz have put together an issue that comprehensively covers age-related changes in women. Their authors, from well-respected institutions, have contributed review articles on the following topics: Declining fertility with reproductive aging: How to protect your patient’s fertility by knowing the milestones; Onset of the transition into menopause: What are the earliest signs; Menstrual cycle changes as women approach the final menses: What matters; Menstrual cycle hormone changes and how they may link to symptoms; Symptom progression across the transition: Not all women are created equal; Cardiovascular implications of vasomotor symptoms and the menopausal transition; Depression and perimenopause :Hormones, genetics and environmental determinants of disease; Sleep, health, and metabolism: Food for thought; Bone health during the menopausal transition and beyond; Sexuality in midlife and beyond; Physical function –moving and aging; Genitourinary changes with aging; and Cognitive changes with reproductive aging, perimenopause, and menopause. Readers will come away with the latest clinical information they need to treat these patients and improve outcomes.

Dr. Caughey has recruited top experts to address the current questions and thinking with regard to the management of labor and delivery. Authors have presented current clinical reviews on the following topics: Defining and managing normal and abnormal first stage of labor; Defining and managing normal and abnormal second stage of labor; Laborist models on labor and delivery; Quality Improvement on Labor and Delivery; Fetal Malposition; Is there a place for outpatient pre-induction cervical ripening; Management of twins on labor and delivery; Cervical ripening techniques: Which is the best; Augmentation of labor: What are the approaches; Elective induction of labor: What is the impact; VBAC trends: Which way is the pendulum swinging; and Update on fetal monitoring. Readers will come away with the current clinical trends and information they need to successfully manage labor and delivery.

The Guest Editors have assembled expert authors to provide current clinical views and recommendations for patients with medical disorders in pregnancy. Clinical reviews are devoted to the following topics: Obstructive sleep apnea in pregnancy; Pregestational Diabetes; Gestational Diabetes; Maternal mortality in the 21 century; Infections in pregnancy and the role of vaccines; Peripartum cardiomyopathy; Update on HIV in pregnancy: Thromboprophylaxis; Opiate abuse in pregnancy.

In this issue of Obstetrics and Gynecology Clinics of North America, guest editor Dr. Sharon T. Phelan brings her considerable expertise to the topic of Prenatal Care. Prenatal care can help prevent complications and inform women about important steps they can take to protect their infant and ensure a healthy pregnancy. This issue not only provides timely updates but also touches on current issues in this fast-changing field, including social determinants of health care, health care disparities, and advocacy for the underserved pregnant patient. - Contains 15 practice-oriented topics including updates in genetic testing for the general obstetrician; updates on evaluation and treatment of common complaints in pregnancy; social determinants of health and health care disparities; updates in mental health care in the prenatal patient; health advocacy for the underserved pregnant patient; and more. - Provides in-depth clinical reviews of prenatal care, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This issue of the Obstetrics and Gynecology Clinics in North America will focus on the advances in the evaluation and management of Recurrent Pregnancy Loss (RPL) that have emerged within the last few years. Although spontaneous pregnancy loss occurs in approximately 15% to 20% of clinically recognized pregnancies in reproductive-aged women, RPL occurs in 2% to 5% of the same population. Recent reports on large populations of women with RPL have helped to characterize the incidence and diversity of this heterogeneous disorder, and a definite cause of pregnancy loss can be established on over 50% of all couples after a thorough evaluation. New diagnostic strategies, which include 23-chromosome microarray genetic testing of the products of conception in failed pregnancies, offer the promise of understanding the cause of most pregnancy losses. These recent advances, combined with the contributions from the authors in this issue of Clinics and many others interested in this field, lead to the publication of the long-awaited publication on evaluation and treatment of RPL from the Practice Committee of the American Society for Reproductive Medicine. A complete evaluation will include investigations into genetic, anatomic, immunologic, endocrinologic, and iatrogenic factors.