The how's and why's of successful drug repositioning Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical, scientific, and operational challenges and opportunities that drug repositioning offers. Readers will learn how to perform the latest experimental and computational methods that support drug repositioning, and detailed case studies throughout the book demonstrate how these methods fit within the context of a comprehensive drug repositioning strategy. Drug Repositioning is divided into three parts: Part 1, Drug Repositioning: Business Case, Strategies, and Operational Considerations, examines the medical and commercial drivers underpinning the quest to reposition existing drugs, guiding readers through the key strategic, technical, operational, and regulatory decisions needed for successful drug repositioning programs. Part 2, Application of Technology Platforms to Uncover New Indications and Repurpose Existing Drugs, sets forth computational-based strategies, tools, and databases that have been designed for repositioning studies, screening approaches, including combinations of existing drugs, and a look at the development of chemically modified analogs of approved agents. Part 3, Academic and Non-Profit Initiatives & the Role of Alliances in the Drug Repositioning Industry, explores current investigations for repositioning drugs to treat rare and neglected diseases, which are frequently overlooked by for-profit pharmaceutical companies due to their lack of commercial return. The book's appendix provides valuable resources for drug repositioning researchers, including information on drug repositioning and reformulation companies, databases, government resources and organizations, regulatory agencies, and drug repositioning initiatives from academia and non-profits. With this book as their guide, students and pharmaceutical researchers can learn how to use drug repositioning techniques to extend the lifespan and applications of existing drugs as well as maximize the return on investment in drug research and development.

World-class branding for the interconnected modern marketplace Kellogg on Branding in a Hyper-Connected World offers authoritative guidance on building new brands, revitalizing existing brands, and managing brand portfolios in the rapidly-evolving modern marketplace. Integrating academic theories with practical experience, this book covers fundamental branding concepts, strategies, and effective implementation techniques as applied to today’s consumer, today’s competition, and the wealth of media at your disposal. In-depth discussion highlights the field’s ever-increasing connectivity, with practical guidance on brand design and storytelling, social media marketing, branding in the service sector, monitoring brand health, and more. Authored by faculty at the world’s most respected school of management and marketing, this invaluable resourceincludes expert contributions on the financial value of brands, internal branding, building global brands, and other critical topics that play a central role in real-world branding and marketing scenarios. Creating a brand—and steering it in the right direction—is a multi-layered process involving extensive research and inter-departmental cooperation. From finding the right brand name and developing a cohesive storyline to designing effective advertising, expanding reach, maintaining momentum, and beyond, Kellogg on Branding in a Hyper-Connected World arms you with the knowledge and skills to: Apply cutting-edge techniques for brand design, brand positioning, market-specific branding, and more Adopt successful strategies from development to launch to leveraging Build brand-driven organizations and reinforce brand culture both internally and throughout the global marketplace Increase brand value and use brand positioning to build a mega-brand In today’s challenging and complex marketplace, effective branding has become a central component of success. Kellogg on Branding in a Hyper-Connected World is a dynamic, authoritative resource for practitioners looking to solve branding dilemmas and seize great opportunities.

The how's and why's of successful drug repositioning Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical, scientific, and operational challenges and opportunities that drug repositioning offers. Readers will learn how to perform the latest experimental and computational methods that support drug repositioning, and detailed case studies throughout the book demonstrate how these methods fit within the context of a comprehensive drug repositioning strategy. Drug Repositioning is divided into three parts: Part 1, Drug Repositioning: Business Case, Strategies, and Operational Considerations, examines the medical and commercial drivers underpinning the quest to reposition existing drugs, guiding readers through the key strategic, technical, operational, and regulatory decisions needed for successful drug repositioning programs. Part 2, Application of Technology Platforms to Uncover New Indications and Repurpose Existing Drugs, sets forth computational-based strategies, tools, and databases that have been designed for repositioning studies, screening approaches, including combinations of existing drugs, and a look at the development of chemically modified analogs of approved agents. Part 3, Academic and Non-Profit Initiatives & the Role of Alliances in the Drug Repositioning Industry, explores current investigations for repositioning drugs to treat rare and neglected diseases, which are frequently overlooked by for-profit pharmaceutical companies due to their lack of commercial return. The book's appendix provides valuable resources for drug repositioning researchers, including information on drug repositioning and reformulation companies, databases, government resources and organizations, regulatory agencies, and drug repositioning initiatives from academia and non-profits. With this book as their guide, students and pharmaceutical researchers can learn how to use drug repositioning techniques to extend the lifespan and applications of existing drugs as well as maximize the return on investment in drug research and development.

This book confronts the decades-overdue Arab revival through a criticism of civilisation, which is composed of two parts: firstly, researching others and identifying our commonalities in the making of success; and, secondly, so as to prepare well for the future decades of global development, find the way to overcome our present obstructions, which will enable a long-awaited revival.

Nervous system diseases represent a major health concern worldwide. Although important financial and professional investment, their etiology and pathophysiology still remain mostly elusive. Moreover, the clinical need of disease-modifying therapies is still unmet. In the last decades, traditional R&D has failed in identifying new effective therapies in many medical areas and drug repositioning has recently emerged as a promising alternative strategy to de novo drug discovery to improve and accelerate therapeutic development. For the first time, Drug Repositioning: Approaches and Applications for Neurotherapeutics reviews history and advances in drug repositioning, with a special focus on therapeutics for nervous system diseases. International experts from Academia, Industry and Non-profit organisations will provide different views on drug repositioning advantages, challenges and specific applications, which will be covered for nervous system diseases including Alzheimer's, Parkinson's, Huntington's diseases, Amyotrophic Lateral Sclerosis, Spinal Muscular Atrophy, ischemic stroke, and psychiatric disorders. This book provides a balanced overview and synthesis of drug repositioning concept, methods and applications for neurotherapeutics. It represents a valuable resource for students, scientists and clinicians working in academic settings, industry and government agencies within the fields of neuroscience, pharmacology, neurology, pharmaceutical sciences, drug discovery and development.

This monograph addresses several critical problems to the operations of shipping lines and ports, and provides algorithms and mathematical models for use by shipping lines and port authorities for decision support. One of these problems is the repositioning of container ships in a liner shipping network in order to adjust the network to seasonal shifts in demand or changes in the world economy. We provide the first problem description and mathematical model of repositioning and define the liner shipping fleet repositioning problem (LSFRP). The LSFRP is characterized by chains of interacting activities with a multi-commodity flow over paths defined by the activities chosen. We first model the problem without cargo flows with a variety of well-known optimization techniques, as well as using a novel method called linear temporal optimization planning that combines linear programming with partial-order planning in a branch-and-bound framework. We then model the LSFRP with cargo flows, using several different mathematical models as well as two heuristic approaches. We evaluate our techniques on a real-world dataset that includes a scenario from our industrial collaborator. We show that our approaches scale to the size of problems faced by industry, and are also able to improve the profit on the reference scenario by over US$14 million.

The book takes the inventory control perspective to tackle empty container repositioning logistics problems in regional transportation systems by explicitly considering the features such as demand imbalance over space, dynamic operations over time, uncertainty in demand and transport, and container leasing phenomenon. The book has the following unique features. First, it provides a discussion of broad empty equipment logistics including empty freight vehicle redistribution, empty passenger vehicle redistribution, empty bike repositioning, empty container chassis repositioning, and empty container repositioning (ECR) problems. The similarity and unique characteristics of ECR compared to other empty equipment repositioning problems are explained. Second, we adopt the stochastic dynamic programming approach to tackle the ECR problems, which offers an algorithmic strategy to characterize the optimal policy and captures the sequential decision-making phenomenon in anticipation of uncertainties over time and space. Third, we are able to establish closed-form solutions and structural properties of the optimal ECR policies in relatively simple transportation systems. Such properties can then be utilized to construct threshold-type ECR policies for more complicated transportation systems. In fact, the threshold-type ECR policies resemble the well-known (s, S) and (s, Q) policies in inventory control theory. These policies have the advantages of being decentralized, easy to understand, easy to operate, quick response to random events, and minimal on-line computation and communication. Fourth, several sophisticated optimization techniques such as approximate dynamic programming, simulation-based meta-heuristics, stochastic approximation, perturbation analysis, and ordinal optimization methods are introduced to solve the complex stochastic optimization problems. The book will be of interest to researchers and professionals in logistics, transport, supply chain, and operations research.