Saving Lives, Buying Time

Saving Lives, Buying Time
Title Saving Lives, Buying Time PDF eBook
Author Institute of Medicine
Publisher National Academies Press
Pages 384
Release 2004-09-09
Genre Medical
ISBN 0309165938

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For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.

Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis

Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis
Title Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis PDF eBook
Author National Academies of Sciences, Engineering, and Medicine
Publisher National Academies Press
Pages 427
Release 2020-04-24
Genre Medical
ISBN 0309672104

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Among the many who serve in the United States Armed Forces and who are deployed to distant locations around the world, myriad health threats are encountered. In addition to those associated with the disruption of their home life and potential for combat, they may face distinctive disease threats that are specific to the locations to which they are deployed. U.S. forces have been deployed many times over the years to areas in which malaria is endemic, including in parts of Afghanistan and Iraq. Department of Defense (DoD) policy requires that antimalarial drugs be issued and regimens adhered to for deployments to malaria-endemic areas. Policies directing which should be used as first and as second-line agents have evolved over time based on new data regarding adverse events or precautions for specific underlying health conditions, areas of deployment, and other operational factors At the request of the Veterans Administration, Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis assesses the scientific evidence regarding the potential for long-term health effects resulting from the use of antimalarial drugs that were approved by FDA or used by U.S. service members for malaria prophylaxis, with a focus on mefloquine, tafenoquine, and other antimalarial drugs that have been used by DoD in the past 25 years. This report offers conclusions based on available evidence regarding associations of persistent or latent adverse events.

Global Technical Strategy for Malaria 2016-2030

Global Technical Strategy for Malaria 2016-2030
Title Global Technical Strategy for Malaria 2016-2030 PDF eBook
Author World Health Organization
Publisher World Health Organization
Pages 35
Release 2015-11-04
Genre Medical
ISBN 9241564997

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The World Health Organization's Global Technical Strategy for Malaria 2016- 2030 has been developed with the aim to help countries to reduce the human suffering caused by the world's deadliest mosquito-borne disease. Adopted by the World Health Assembly in May 2015 it provides comprehensive technical guidance to countries and development partners for the next 15 years emphasizing the importance of scaling up malaria responses and moving towards elimination. It also highlights the urgent need to increase investments across all interventions - including preventive measures diagnostic testing treatment and disease surveillance- as well as in harnessing innovation and expanding research. By adopting this strategy WHO Member States have endorsed the bold vision of a world free of malaria and set the ambitious new target of reducing the global malaria burden by 90% by 2030. They also agreed to strengthen health systems address emerging multi-drug and insecticide resistance and intensify national cross-border and regional efforts to scale up malaria responses to protect everyone at risk.

Malaria: Drugs, Disease and Post-genomic Biology

Malaria: Drugs, Disease and Post-genomic Biology
Title Malaria: Drugs, Disease and Post-genomic Biology PDF eBook
Author David Sullivan
Publisher Springer Science & Business Media
Pages 447
Release 2006-01-09
Genre Medical
ISBN 3540290885

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Despite rapid increases in knowledge, malaria continues to kill more than a million people each year and causes symptomatic disease in a further 300 million individuals. This volume brings some of the world's best investigators to describe recent advances in both the scientific and clinical aspects of malaria, and bridges between the two.

Report on antimalarial drug efficacy, resistance and response

Report on antimalarial drug efficacy, resistance and response
Title Report on antimalarial drug efficacy, resistance and response PDF eBook
Author World Health Organization
Publisher World Health Organization
Pages 78
Release 2020-08-31
Genre Medical
ISBN 9240012818

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"Resistance to antimalarial drugs challenges our ability to save lives threatened by malaria, and to eliminate the burden that malaria places on individuals and societies. This burden is substantial, with malaria having caused an estimated 228 million cases and 405 000 deaths in 2018 (1). The Global technical strategy for malaria 2016–2030, adopted at the World Health Assembly in 2015, highlights the potential of antimalarial drug resistance to seriously weaken the effectiveness of malaria responses and erode the gains achieved (2). Monitoring antimalarial drug efficacy and resistance is important for the early detection of resistance, which in turn enables timely action to prevent its spread and limit the impact on global health. Measurement of drug efficacy and resistance in malaria is complex. Studies of clinical and parasitological outcomes are the main sources of information on which national malaria control programmes base treatment policy; however, other studies are needed to confirm drug resistance if suspected." -- Introduction.

Global Report on Antimalarial Drug Efficacy and Drug Resistance

Global Report on Antimalarial Drug Efficacy and Drug Resistance
Title Global Report on Antimalarial Drug Efficacy and Drug Resistance PDF eBook
Author
Publisher
Pages 115
Release 2010
Genre Antimalarials
ISBN

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This report provides a comprehensive, global overview of antimalarial drug efficacy and the resistance of malaria parasites to the antimalarial medicines used between 2000 and June 2010. Policy-makers in national ministries of health will benefit from this document, as it provides both a global and a regional picture of the efficacy of the antimalarial medicines currently used in national treatment programmes. In addition, the report will be a reference for scientists, enhancing their understanding of the complexity of antimalarial drug resistance.

Economic Analysis of Malaria Control in Sub-Saharan Africa

Economic Analysis of Malaria Control in Sub-Saharan Africa
Title Economic Analysis of Malaria Control in Sub-Saharan Africa PDF eBook
Author Catherine Cavallaro Goodman
Publisher
Pages 218
Release 2000
Genre Africa, Sub-Saharan
ISBN

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