George Hull (1590-1659) and his family emigrated in 1630 from England to Dorchester, Massachusetts, moving in 1636 to Windsor, Connecticut. Joseph Hull (1596-1665), his brother, emigrated in 1635 and died at York, Maine. Richard Hull (1599-1662), not a relative, immigrated before 1636 to Massachusetts, moving to New Haven, Connecticut in 1639. Descendants of these three immigrants lived mainly in New York, New Jersey, Connecticut, Rhode Island, New Hampshire, Tennessee and California.

This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.

Views of the Maritime Commission on two Senate amendments to H. R. 3261, a bill to amend the Act of April 29, 1943, to authorize the return to private ownership of Great Lakes vessels and vessels of 1,000 gross tons or less. The amendments deal with just compensation and establishing an arbitration procedure.