Advances in Radiation Biology: Relative Radiation Sensitivities of Human Organ Systems, Part III, is the third volume of the series "Relative Radiation Sensitivities of Human Organ Systems." It presents reviews of organ systems not included in the preceding two parts (Advances in Radiation Biology, Volumes 12 and 14). The subject matter contained in the current volume is viewed through the eyes of the radiation therapist. Although the presentations have strong clinical overtones, an effort has been made, wherever possible, also to address the radiobiological bases of radiation sensitivity of organs. The book contains seven chapters and begins with a study on radiation damage to the kidney. This is followed by separate chapters on inherent or intrinsic radiosensitivity of human cells; the impact of brachytherapy (i.e., short-distance radiation treatment using photon radiation) on tumors; and human tissue tolerance to fast neutron radiotherapy. Subsequent chapters deal with normal tissue effects of combined hyperthermia and radiotherapy; the impact of ionizing radiation on the successive stages of human development in utero; and developments in theoretical knowledge and practical applications of ionizing radiations which have taken place in a little less than a century.

Advances in Radiation Biology, Volume 14: Relative Radiation Sensitivities of Human Organ Systems, Part II focuses on radiation sensitivities of particular human organ systems. The sensitivities are then assessed based on the severity and the rapidity in which the effects of radiation manifest. The opening chapter surveys the clinical and experimental data on approaches toward the prevention of bladder complications in clinical radiotherapy. A discussion on HeLa cells, which are of special importance in human cervical cancer therapy, is then presented. In presenting this topic, this book emph ...

Advances in Radiation Biology, Volume 12: Relative Radiation Sensitivities of Human Organ Systems covers articles on the response of selected human organ and tissue systems to exposure to ionizing radiation. The book presents articles on the relative radiosensitivities of the thymus, spleen, lymphohemopoietic systems, small and large intestines, oral cavity, larynx, pharynx, and esophagus. The text also includes articles on the relative radiation sensitivity of the integumentary system, as well as the relative radiosensitivity of the human lung and fetal tissues. The tolerance of the central and peripheral nervous system to therapeutic irradiation is also encompassed. Radiation biologists, oncologists, physicians, pediatricians, and medical students will find the book useful.

Advances in Radiation Biology, Volume 14: Relative Radiation Sensitivities of Human Organ Systems, Part II focuses on radiation sensitivities of particular human organ systems. The sensitivities are then assessed based on the severity and the rapidity in which the effects of radiation manifest. The opening chapter surveys the clinical and experimental data on approaches toward the prevention of bladder complications in clinical radiotherapy. A discussion on HeLa cells, which are of special importance in human cervical cancer therapy, is then presented. In presenting this topic, this book emphasizes radiation sensitivity and radiobiology of tumors of the cervix of the female genital tract. Chapter 3 briefly covers imaging techniques for hypothalamic-pituitary dysfunction diagnosis and introduces hormonal therapy for remarkable improvements in both physical and mental status of patients. The subsequent chapters discuss basic radiobiology of the thyroid in experimental animal and the late effects of therapeutic and low-level radiation in humans. The radiation damages in bone and cartilage and the changes occurring in the various types of vessels during radiation therapy are also discussed. Chapter 7 presents the basic biology of spermatogenesis, as it applies to the understanding of radiation effects. This chapter also explains the studies of rodents, as it applies to subhuman primates and to man. Moreover, it considers as well the mechanisms of radiation damage to the testis, as elucidated by experimental studies of rodents and subhuman primates. Finally, it presents the limited data available on man and discusses these data in terms of the biology of the system known from experimental studies. The concluding chapter describes the features of radiation-induced hepatic injury, ranging from asymptomatic biochemical or a radiographic abnormality to fulminant, fatal hepatic failure. Radiation biologists will greatly benefit from this book, especially those who are involved in dose fractionation in radiation therapy.

Expand your understanding of the physics and practical clinical applications of advanced radiation therapy technologies with Khan's The Physics of Radiation Therapy, 5th edition, the book that set the standard in the field. This classic full-color text helps the entire radiation therapy team—radiation oncologists, medical physicists, dosimetrists, and radiation therapists—develop a thorough understanding of 3D conformal radiotherapy (3D-CRT), stereotactic radiosurgery (SRS), high dose-rate remote afterloaders (HDR), intensity modulated radiation therapy (IMRT), image-guided radiation therapy (IGRT), Volumetric Modulated Arc Therapy (VMAT), and proton beam therapy, as well as the physical concepts underlying treatment planning, treatment delivery, and dosimetry. In preparing this new Fifth Edition, Dr. Kahn and new co-author Dr. John Gibbons made chapter-by-chapter revisions in the light of the latest developments in the field, adding new discussions, a new chapter, and new color illustrations throughout. Now even more precise and relevant, this edition is ideal as a reference book for practitioners, a textbook for students, and a constant companion for those preparing for their board exams. Features Stay on top of the latest advances in the field with new sections and/or discussions of Image Guided Radiation Therapy (IGRT), Volumetric Modulated Arc Therapy (VMAT), and the Failure Mode Event Analysis (FMEA) approach to quality assurance. Deepen your knowledge of Stereotactic Body Radiotherapy (SBRT) through a completely new chapter that covers SBRT in greater detail. Expand your visual understanding with new full color illustrations that reflect current practice and depict new procedures. Access the authoritative information you need fast through the new companion website which features fully searchable text and an image bank for greater convenience in studying and teaching. This is the tablet version which does not include access to the supplemental content mentioned in the text.

Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanisms. While the vastness of the field and the rapid accumulation of data may preclude the possibility of absorbing and retaining more than a fraction of the available information, a solid understanding of the underlying principles is essential. Extensively revised and updated with four new chapters and an expanded glossary, this fifth edition of the classic text, Principles and Methods of Toxicology provides comprehensive coverage in a manageable and accessible format. New topics include 'toxicopanomics', plant and animal poisons, information resources, and non-animal testing alternatives. Emphasizing the cornerstones of toxicology-people differ, dose matters, and things change, the book begins with a review of the history of toxicology and followed by an explanation of basic toxicological principles, agents that cause toxicity, target organ toxicity, and toxicological testing methods including many of the test protocols required to meet regulatory needs worldwide. The book examines each method or procedure from the standpoint of technique and interpretation of data and discusses problems and pitfalls that may be associated with each. The addition of several new authors allow for a broader and more diverse treatment of the ever-changing and expanding field of toxicology. Maintaining the high-quality information and organizational framework that made the previous editions so successful, Principles and Methods of Toxicology, Fifth Edition continues to be a valuable resource for the advanced practitioner as well as the new disciple of toxicology.