Regulatory Mechanisms of Intracellular Membrane Transport
Title | Regulatory Mechanisms of Intracellular Membrane Transport PDF eBook |
Author | Sirkka Keränen |
Publisher | Springer Science & Business Media |
Pages | 228 |
Release | 2004-08-27 |
Genre | Medical |
ISBN | 9783540223023 |
This book deals with the molecular mechanisms of membrane trafficking, a central eukaryotic cell biological process. In the post-genomic era many essential molecules involved in intracellular membrane/protein transport are emerging. A huge task now is to compile the molecular networks that govern these processes. Understanding of regulatory processes and participating molecules are likely to reveal global cellular regulatory circuits that couple membrane trafficking with other cellular functions. Such cell biological features are only starting to emerge. This book puts special emphasis on such mechanisms and processes. The contents discusses the role of coat proteins, tethering complexes, small rab GTPases, Sec1-family proteins and SNARE molecule phosphorylation in exocytosis, endocytosis and membrane fusion. In addition, the role of lipids in vesicle formation and membrane fusion, and some specialized cell biological denovo membrane generation processes are discussed.
Regulatory Mechanisms of Intracellular Membrane Transport
Title | Regulatory Mechanisms of Intracellular Membrane Transport PDF eBook |
Author | Sirkka Keränen |
Publisher | Springer |
Pages | 214 |
Release | 2014-10-08 |
Genre | Science |
ISBN | 9783662308141 |
This book deals with the molecular mechanisms of membrane trafficking, a central eukaryotic cell biological process. In the post-genomic era many essential molecules involved in intracellular membrane/protein transport are emerging. A huge task now is to compile the molecular networks that govern these processes. Understanding of regulatory processes and participating molecules are likely to reveal global cellular regulatory circuits that couple membrane trafficking with other cellular functions. Such cell biological features are only starting to emerge. This book puts special emphasis on such mechanisms and processes. The contents discusses the role of coat proteins, tethering complexes, small rab GTPases, Sec1-family proteins and SNARE molecule phosphorylation in exocytosis, endocytosis and membrane fusion. In addition, the role of lipids in vesicle formation and membrane fusion, and some specialized cell biological denovo membrane generation processes are discussed.
Trafficking Inside Cells
Title | Trafficking Inside Cells PDF eBook |
Author | Nava Segev |
Publisher | Springer Science & Business Media |
Pages | 459 |
Release | 2010-05-30 |
Genre | Science |
ISBN | 038793877X |
This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.
Molecular Biology of the Cell
Title | Molecular Biology of the Cell PDF eBook |
Author | |
Publisher | |
Pages | 0 |
Release | 2002 |
Genre | Cells |
ISBN | 9780815332183 |
Regulation and Development of Membrane Transport Processes
Title | Regulation and Development of Membrane Transport Processes PDF eBook |
Author | James Stephen Graves |
Publisher | Wiley-Interscience |
Pages | 314 |
Release | 1985 |
Genre | Science |
ISBN |
This state-of-the-art assessment describes the means by which cell membrane transport systems are regulated in both epithelial and nonepithelial cells. Regulation and Development of Membrane Transport Processes leads readers from a physiological description of regulation toward a more mechanistic level of understanding. Distinguished researchers in physiology, biochemistry, genetics, and pharmacology offer key insights into the regulatory processes evoked by external stimuli, such as hormones or substrate limitation, and by the internal stimulus of genetically programmed development. Their multidisciplinary efforts define three forms of regulations: (1) gene expression leading to de novo synthesis; (2) insertion and removal of cytoplasmic membrane vesicles; and (3) in situ modification of the transport system in the membrane. Regulation and Development of Membrane Transport Processes reviews a wide spectrum of transport regulatory phenomena in eukaryotic cells and provides the groundwork for future research.
Magnesium in the Central Nervous System
Title | Magnesium in the Central Nervous System PDF eBook |
Author | Robert Vink |
Publisher | University of Adelaide Press |
Pages | 354 |
Release | 2011 |
Genre | Medical |
ISBN | 0987073052 |
The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
Intracellular Transport
Title | Intracellular Transport PDF eBook |
Author | Katherine Brehme Warren |
Publisher | Academic Press |
Pages | 344 |
Release | 2014-05-12 |
Genre | Science |
ISBN | 1483223752 |
Intracellular Transport is a collection of papers that examines the processes of and the mechanisms underlying intracellular transport. One paper describes that all active transport processes in the amoeba are intracellular and depend on dynamic transformations of membrane into cytoplasm, and of cytoplasm into membrane. Another paper discusses the kinetics of membrane transport, of which the phenomena of counterflow can become a "mobile carrier" system. The paper notes that the specific transport properties of membranes are conferred by the proteins of the surfaces that are grouped as macromolecular complexes, probably similar to those of enzymes. One paper describes the concept of parametric pumping, an oscillation-driven separation process, as a possible model for active transport in biological cells. Another paper compares the fine-scale diffusion effects that happen in a mixture without large-scale concentration gradients and where the effect are on a large scale. The homogenous kinetic law can be used in the large-scale situation; the law already can account for any of the fine-scale diffusion effects. The paper notes that without large-scale concentration gradients, the transport event is from a local region to a nearby reaction site only. Where the effects are on a large scale, the diffusion results in a gross transport of over distances larger than molecular dimensions. This collection can prove useful for mathematicians, cellular biologists, physical chemists, physiologists, electron microscopicists, geneticists, and engineers.