Regulation of G Protein-coupled Receptor Function and Expression
Title | Regulation of G Protein-coupled Receptor Function and Expression PDF eBook |
Author | Jeffrey L. Benovic |
Publisher | |
Pages | 330 |
Release | 2000 |
Genre | Medical |
ISBN |
This comprehensive text describes many techniques that are used to define the molecular mechanisms involved in receptor regulation. It covers a broad range of important concepts and methodologies in the study of G protein-coupled receptors.
The G Protein-Coupled Receptors Handbook
Title | The G Protein-Coupled Receptors Handbook PDF eBook |
Author | Lakshmi A. Devi |
Publisher | Springer Science & Business Media |
Pages | 414 |
Release | 2008-03-01 |
Genre | Medical |
ISBN | 1592599192 |
A comprehensive survey of the many recent advances in the field of G protein-coupled receptors (GPCR). The authors describe the current knowledge of GPCR receptor structure and function, the different mechanisms involved in the regulation of GPCR function, and the role of pharmacological chaperones in GPCR folding and maturation. They also present new findings about how GPCR dimerization/oligomerization modifies the properties of individual receptors and show how recent developments are leading to significant advances in drug discovery, such as the detection of ligands for orphan GPCRs. Also discussed are the most recent developments that could lead to new drug discoveries: the role of GPCRs in mediating pain, the development of receptor-type selective drugs based on the structural plasticity of receptor activation, and the identification of natural ligands of orphan GPCRs (deorphanization) as possible drug targets.
Neuromorphic Olfaction
Title | Neuromorphic Olfaction PDF eBook |
Author | Krishna C. Persaud |
Publisher | CRC Press |
Pages | 237 |
Release | 2016-04-19 |
Genre | Medical |
ISBN | 1439871728 |
Many advances have been made in the last decade in the understanding of the computational principles underlying olfactory system functioning. Neuromorphic Olfaction is a collaboration among European researchers who, through NEUROCHEM (Fp7-Grant Agreement Number 216916)-a challenging and innovative European-funded project-introduce novel computing p
Regulation of G Protein-Coupled Receptors
Title | Regulation of G Protein-Coupled Receptors PDF eBook |
Author | Jeffrey L. Benovic |
Publisher | |
Pages | |
Release | 1997-07-01 |
Genre | Science |
ISBN | 9780412139819 |
G Protein-Coupled Receptors - Part B
Title | G Protein-Coupled Receptors - Part B PDF eBook |
Author | |
Publisher | Elsevier |
Pages | 194 |
Release | 2023-01-25 |
Genre | Science |
ISBN | 0323994350 |
G Protein-Coupled Receptors, Part B, Volume 195 represents the largest class of cell H103 surface proteins that have intricate involvement in nearly every physiological process in our body. Approximately one third of the clinically prescribed medicines target GPCRs and the quest to improve the exiting GPCR-targeting therapeutics continues. Sections in this volume include Adhesion G protein-coupled receptors: Structure and functions, Molecular and cellular mechanisms underlying brain region-specific cannabinoid receptor modulation by estradiol across the rodent estrus cycle, Probing the orphan receptors: Tools and directions, Asymmetric activation of Class C GPCRs, Common and selective signal transduction mechanisms of GPCRs, and much more. Covers a broad range of topics related to GPCR activation and signaling Provides several receptor systems, with an emphasis on emerging paradigms Includes different processes and model systems, with a focus on GPCRs
G Protein-Coupled Receptors - Part A
Title | G Protein-Coupled Receptors - Part A PDF eBook |
Author | |
Publisher | Elsevier |
Pages | 232 |
Release | 2022-11-08 |
Genre | Science |
ISBN | 0323994326 |
G Protein-Coupled Receptors, Part A, Volume 193 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field. G protein-coupled receptors (GPCRs) represent the largest class of cell surface proteins with an intricate involvement of nearly every physiological process in our body. Approximately, one third of the clinically prescribed medicines target GPCRs and the quest to improve the exiting GPCR-targeting therapeutics continues. These two volumes are focused on activation, signaling and regulation of GPCRs with specific examples of receptor systems and cellular processes. Covers a broad range of topics related to GPCR activation and signaling Covers several receptor systems with an emphasis on emerging paradigms Covers different processes and model systems with a focus on GPCRs
Principles of Endocrinology and Hormone Action
Title | Principles of Endocrinology and Hormone Action PDF eBook |
Author | Antonino Belfiore |
Publisher | Springer |
Pages | 0 |
Release | 2018-02-08 |
Genre | Medical |
ISBN | 9783319446745 |
This volume provides comprehensive coverage of the current knowledge of the physiology of the endocrine system and hormone synthesis and release, transport, and action at the molecular and cellular levels. It presents essential as well as in-depth information of value to both medical students and specialists in Endocrinology, Gynecology, Pediatrics, and Internal Medicine. Although it is well established that the endocrine system regulates essential functions involved in growth, reproduction, and homeostasis, it is increasingly being recognized that this complex regulatory system comprises not only hormones secreted by the classic endocrine glands but also hormones and regulatory factors produced by many organs, and involves extensive crosstalk with the neural and immune system. At the same time, our knowledge of the molecular basis of hormone action has greatly improved. Understanding this complexity of endocrine physiology is crucial to prevent endocrine disorders, to improve the sensitivity of our diagnostic tools, and to provide the rationale for pharmacological, immunological, or genetic interventions. It is such understanding that this book is designed to foster.