This book discusses the current research concepts and the emerging technologies in the field of stem cells and tissue engineering. It is the first authoritative reference documenting all the ways that plastic surgical practice and regenerative medicine science overlap or provide a road map for the future of both specialties. The Editors have provided a valuable service by gathering in one place the leading voices in these two fields in clear and concise manner. Divided into five parts, the book opens with a description of the elements of regenerative medicine including definitions, basic principles of soft and bone tissue regeneration, biomaterials and scaffolds. Current research concepts are explored in the second part of this book, for example mechanotransduction and the utility of extracellular vesicles. In the third part, the editors present the emerging technologies and highlight the novel perspectives on bionic reconstruction and biomimetics in surgery and regenerative medicine. Part four deals with translational aspects including practical information on moving scientific findings from bench to bedside. The final part then describes in detail applications in clinical plastic surgery. Written by leading experts this book is an invaluable resource for researchers, students, beginners and experienced clinicians in a range of specialties. "In your hands is a comprehensive encyclopedia of two rapidly converging fields. Drs Duscher and Shiffman have done an outstanding job of highlighting the interdependent relationship between plastic surgery and regenerative medicine. Ultimately, this is to the benefit of both fields." - Geoffrey C. Gurtner, MD, FACS Johnson and Johnson Distinguished Professor of Surgery Professor (by courtesy) of Bioengineering and Materials Science Inaugural Vice Chairman of Surgery for Innovation Stanford University School of Medicine

This book presents the latest advances in the field of regenerative medicine in plastic surgery. It is the first authoritative reference documenting all the ways that plastic surgical practice and regenerative medicine science overlap or provide a road map for the future of both specialties. The Editors have provided a valuable service by gathering in one place the leading voices in these two fields in clear and concise manner.The first part introduces readers to essential principles of skin and soft tissue regeneration, e.g. the possibility of using mesenchymal stem cells for wound healing. Since bone serves as a supportive tissue in most of the body, bone regeneration is an important aspect of regenerative medicine; accordingly, the second part discusses the novel bone implants, activated bone grafts and bone tissue engineering. The book’s third part, focusing on cartilage regeneration, includes chapters on e.g. stem cells and ear regeneration. In turn, part four addresses muscle and tendon regeneration: from tendon to bone and tendon to muscle, as well as aging in the realm of muscle regeneration. Lastly, part five highlights nerve regeneration, deepening surgeons’ knowledge to help them successfully treat injuries to the peripheral neural system. Written by leading experts this book is an invaluable resource for researchers, students, beginners and experienced clinicians in a range of specialties. "With beautiful clinical images and artwork, this book will be a central companion to both practicing plastic surgeons who wish to remain abreast of oncoming technologic advances and regenerative medicine researchers who wish to understand the current state of the art of surgical reconstruction." - Geoffrey C. Gurtner, MD, FACS Johnson and Johnson Distinguished Professor of Surgery Professor (by courtesy) of Bioengineering and Materials Science Inaugural Vice Chairman of Surgery for Innovation Stanford University School of Medicine

This textbook was finalized during the worldwide COVID-19 pandemic. For years prior to the pandemic, clinical trials have shown improvement and cures of pulmonary disorders with the intravenous administration of mesenchymal stem cells. These cells are administered into the venous system, pass through the heart, and then lodge in the capillary network of the lungs where they decrease scar tissue and stimulate the regeneration of new lung tissue. The known benefits of cell therapy for pulmonary disease has been the foundation for the use of allogeneic stem cells to effectively treat (and in some cases cure) COVID-19-related lung disorders. Sadly, many of the highly qualified health care professionals caring for these critically ill patients are unfamiliar with the concept of stem cells and regenerative medicine. This unfamiliarity has resulted in patients throughout the world not receiving the benefit of these potentially life-saving treatments. The goal of this textbook is to provide a basic scientific and clinical multispecialty reference source for stem cells and regenerative medicine to be used as an extension of the American College of Regenerative Medicine.™ Chapters focus on basic science as well as the extravascular applications of regenerative medicine for all hard and soft tissues of the body including musculoskeletal and orthopedics, dental and maxillofacial surgery, and dermatology and plastic surgery. Other topics include plasma products such as PRP and PPP, tissue banking, stem cell expansion, and regulatory guidelines. It is our hope that this textbook will assist in the following areas: - Academic institutions will utilize this textbook as a reference source to educate health care professionals of the future, so that regenerative medicine is integrated into the core curriculum and foundation of medical learning. These professionals include medical doctors of all specialties, dentists and maxillofacial surgeons, veterinarians, researchers, nurses, study coordinators, physical therapists, occupational therapists, perfusionists, healthcare and life science attorneys, advocates, administrators, and policy makers. - Practicing health care professionals who have already finished their training will read this textbook with an open mind and understand more about stem cells and regenerative medicine. - To provide a foundation of accurate peer-reviewed scientific and clinical information for patient and industry advocates, as well as those involved in formulation of health care policy.

This book discusses the current research concepts and the emerging technologies in the field of stem cells and tissue engineering. It is the first authoritative reference documenting all the ways that plastic surgical practice and regenerative medicine science overlap or provide a road map for the future of both specialties. The Editors have provided a valuable service by gathering in one place the leading voices in these two fields in clear and concise manner. Divided into five parts, the book opens with a description of the elements of regenerative medicine including definitions, basic principles of soft and bone tissue regeneration, biomaterials and scaffolds. Current research concepts are explored in the second part of this book, for example mechanotransduction and the utility of extracellular vesicles. In the third part, the editors present the emerging technologies and highlight the novel perspectives on bionic reconstruction and biomimetics in surgery and regenerative medicine. Part four deals with translational aspects including practical information on moving scientific findings from bench to bedside. The final part then describes in detail applications in clinical plastic surgery. Written by leading experts this book is an invaluable resource for researchers, students, beginners and experienced clinicians in a range of specialties. "In your hands is a comprehensive encyclopedia of two rapidly converging fields. Drs Duscher and Shiffman have done an outstanding job of highlighting the interdependent relationship between plastic surgery and regenerative medicine. Ultimately, this is to the benefit of both fields."--Geoffrey C. Gurtner, MD, FACS Johnson and Johnson Distinguished Professor of Surgery Professor (by courtesy) of Bioengineering and Materials Science Inaugural Vice Chairman of Surgery for Innovation Stanford University School of Medicine

This book presents the state-of-art in regenerative procedures currently applied by aesthetic physicians, plastic surgeons and dermatologists. It is divided into two parts, the first of which provides a detailed introduction to aesthetic medicine and the aging process. The second part, in turn, addresses the current status of techniques and technologies with regard to autologous grafts, covering fat transfer, blood grafts, skin grafts and stem cells. The book examines the surgical applications of these grafts, as well as potential side effects and limitations. Therapy combinations and outcomes round out the coverage. Aesthetic physicians, plastic surgeons and dermatologists interested in performing regenerative procedures for aesthetic purposes will find this book to be a valuable guide.

Comprehensive and fully up to date, the six-volume Plastic Surgery remains the gold standard text in this complex area of surgery. Completely revised to meet the demands of both the trainee and experienced surgeon, Aesthetic Surgery, Volume 2 of Plastic Surgery, 5th Edition, features new, full-color clinical photos, procedural videos, lectures, and authoritative coverage of hot topics in the field. Editor-narrated video presentations offer a step-by-step audio-visual walkthrough of techniques and procedures. New chapters cover local anesthesia, anatomic blocks of the face and neck, facelifts, neck rejuvenation, energy devices in aesthetic surgery, and aesthetic genital surgery; coverage throughout includes new, pioneering translational work shaping the future of aesthetic surgery. New digital video preface by Dr. Peter C. Neligan addresses the changes across all six volumes. New treatment and decision-making algorithms added to chapters where applicable. New video lectures and editor-narrated slide presentations offer a step-by-step audiovisual walkthrough of techniques and procedures. Evidence-based advice from an expanded roster of international experts allows you to apply the very latest advances in aesthetic surgery and ensure optimal outcomes. Purchase this volume individually or own the entire set, with the ability to search across all six volumes online!

Readers will discover the relatively new and rapidly growing field of regenerative surgery and fat grafting, valuable for numerous plastic surgery, reconstructive, and aesthetic/cosmetic essentials. Though many books have covered specific areas or topics in regenerative surgery, the market lacks a work that tackles the full spectrum of regenerative surgery and its clinical application. This book responds to that need and presents chapters written by the best: world-renowned surgeons in their field. After an introduction that reflects basic research, most of the book focuses on clinical experience as it relates to applied techniques of processing fat and on the different uses from head to toe. Readers will learn about the history of regenerative surgery, important definitions and background information, and the evidence supporting the use of regenerative surgery. Practitioners will also find valuable guidance regarding the application of stem cells, evaluation of patient needs, and operative techniques for fat transfer. Subsequent chapters address topics such as graft types, the skin, wound healing, scar treatment, osteoarthritis, burns, scleroderma, hair rejuvenation, facial enhancement combined with facelift, chin augmentation with fat, and breast argumentation or reconstruction with fat. Particular attention is paid to gluteal augmentation with fat, body contouring, genital male and female rejuvenation, and upper and lower extremity regenerative surgery. Surgical anatomy and complications treatment and prevention were emphasized when applied. This resulted is two volumes that encompass 114 chapters, with multiple figures, and video clips, written by 242 authors (including 72 female colleagues) from five continents. Highly informative and carefully structured, this book provides invaluable insight for beginners and experienced plastic surgeons alike, while benefitting advanced surgeons, specialists, and undergraduate and graduate students.