This issue of Otolaryngologic Clinics, guest edited by Drs. Abtin Tabaee and Edward D. McCoul, is devoted to Refractory Chronic Rhinosinusitis. Articles in this issue include: Classification of Chronic Rhinosinusitis: Working Towards Personalized Diagnosis; Bacterial Pathogens and the Microbiome; Biofilm and Osteitis; Refractory Chronic Sinusitis with Polyposis; Aspirin-Exacerbated Respiratory Disease; Systemic and Odontogenic Etiologies in Chronic Rhinosinusitis; Genetic and Immune Dysregulation in Chronic Rhinosinusitis; Office Procedures in Refractory Chronic Rhinosinusitis; Topical Therapies and Stents; Revision Functional Endoscopic Sinus Surgery; Extended Endoscopic and Open Sinus Surgery for Refractory Chronic Rhinosinusitis; and An Algorithm for Comprehensive Evaluation and Management of Refractory Chronic Rhinosinusitis.

In this issue of Otolaryngologic Clinics, guest editors Drs. Devyani Lal, Angela Donaldson, and David Jang bring their considerable expertise to the topic of Unified Airway Disease. Unified airway disease is a recently defined entity that alludes to inflammation disease processes that involve both upper and lower airway, and co-management of these conditions by otolaryngologists and allergy immunologists often result in improved outcomes. In this issue, experts in the field provide a thorough overview of the pathophysiology, diagnosis, and management of unified airway disease through the perspective of an otolaryngologist co-managing the patient with an allergy-immunology colleague. - Contains 16 practice-oriented topics including environmental factors; eosinophilic disease; non-eosinophilic and granulomatous disease; cystic fibrosis; pediatric unified airway disease; unified airway disease medical and surgical management; future directions; and more. - Provides in-depth clinical reviews on unified airway disease, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This issue of Otolaryngologic Clinics, guest edited by Drs. Natasha Mirza and Jennifer Y. Lee, is devoted to Geriatric Otolaryngology. Articles in this issue include: Economics of the Aging Population: The expected growth and demand for Otolaryngology services; Hearing: Presbycusis and innovations in hearing augmentation; Vertigo and Dizziness: Understanding and Managing Falls Risk; Head and Neck Cancer; Endocrine Surgery; Voice Alteration; Dysphagia; Gastroesophageal/LaryngoPharyngeal Reflux; The Aging Face; Rhinitis and Sinusitis; Smell and Taste; Sleep Apnea and Sleep Disordered Breathing; Medical and Preoperative Evaluation of the Elderly Patient; and The Emerging Field of Geriatric Otolaryngology.

This issue of Otolaryngologic Clinics, guest edited by Drs. Sarah K. Wise, Ashkan Monfared, and Nicole C. Schmitt is devoted to Biologics in Otolaryngology. This issue is one of six selected each year by our series consulting editor, Dr. Sujana S. Chandrasekhar. Articles in this issue include: Biologics in otolaryngology overview, Current evidence for biologic therapy in chronic rhinosinusitis with nasal polyposis, Choosing the right patient for biologic therapy in CRSwNP, Knowledge gaps and research needs for biologic therapy in rhinology practice, Mechanisms and practical use of biologic therapies for allergy and asthma indications, Immunotherapeutic strategies in head and neck cancer, Cetuximab in head and neck cancer, Anti-PD-1 immune checkpoint blockade for head and neck cancer, Advances in adoptive cell therapy for head and neck cancer, Biologics for the treatment of recurrent respiratory papillomatosis, Past and future biologics for otologic disorders, Biological treatments for Neurofibromatosis Type II and other skullbase disorders, and Biologics in treatment of autoimmune ear disorders.

This issue of Otolaryngologic Clinics, Guest Edited by Murugappan Ramanathan Jr. and James Whitman Mims, is devoted to Allergy for the Otolaryngologist. Articles in this issue include: New Horizons in the Management of Allergy; The Role of the Sinonasal Epithelium in Allergy; The Role of Allergy in Chronic Rhinosinusitis; Manifestations of Inhalant Allergies Beyond the Nose; The Role of Allergy in Otologic Disease; Asthma Management for the Otolaryngologist; Rational Approach to Allergy Testing (in vitro/in vivo); Advances in Food Allergy; Contemporary Pharmacotherapy of Allergic Inflammation; Clinical Applications of SLIT; Efficacy of SLIT/SCIT; Immunotherapy: Treating with Fewer Allergens?; Management of Anaphylaxis; and Future Horizons in Allergy.

Management of paranasal sinus disorders is not only a test of knowledge but it is also an art form. Great progress has been made on endoscopic sinus surgery in recent decades and this technique lets us look into the remote corners of sinuses. However, we still have a lot of challenging issues. The only way to solve these problems is to face them. Based on these concepts, this book incorporates new clinical and research developments as well as future perspectives in the ever-expanding field of rhinology. The book is a comprehensive reference for ENT residents and practicing otolaryngologists who wish to expand their expertise, develop a broader armamentarium of techniques, and successfully manage their patients with sinonasal disorders.

This issue of Otolaryngologic Clinics of North America, devoted to Endoscopic Ear and Eustachian Tube Surgery, is guest edited by Drs. João Flávio Nogueira and Muaaz Tarabichi. Articles in this outstanding issue include: Anatomy of the Eustachian Tube; Physiology of the Eustachian Tube; Eustachian Tube Function and Testing; Radiology of the Eustachian Tube; Middle Ear and Eustachian Tube Dysfunction; Endoscopic Eustachian Tube Transnasal Surgery; Endoscopic Anatomy of the Protympanic Space; Outcomes Following Endoscopic Ear Surgery; Endoscopic Management of Superior Semicircular Canal Dehiscence; Endoscopic Management of Tumors in Middle Ear and Mastoid; Outcomes Following Endoscopic Stapes Surgery; Transtympanic Balloon Dilation of the Eustachian Tube; Selective Dysventilation Syndrome; Restoring Petrous Bone Ventilation; and Endoscopic Techniques in Tympanoplasty.