The mainstream view of the immune system is concerned with molecular and cellular details resulting in a picture of immense complexity. Many immunologists live with this complexity, hoping that a series of breakthroughs will eventually add up to a greater insight. However, the forest is ignored for the trees and a 'Systems Approach' is vital for a better understanding. Peter Bretscher develops here a unique perspective on how the immune system functions as an integrated organ, by taking account of observations and concepts at the 'level of system' that are often half forgotten or ignored. A colleague, on reading this book, wrote: "Those who have followed Peter's work these past 50 years will recognize this book for what it really is - a rare achievement, a scientific masterpiece. It is a must read for all those Immunologists and Clinicians who want to find effective immunological cures for the many debilitating health issues that confront us. Peter Bretscher has produced a lucid and logical exposition of the rules governing how the adaptive immune system responds to all foreign antigens whether bacterial, viral or modifications of the self, which emerge in cancer or autoimmune conditions. This book is a testament to Louis Pasteur's dictum that there is no applied science, just the application of basic science." Rediscovering the Immune System is written in a jargon-free and accessible style. This personal perspective is an ideal guide to the immune system for students, researchers and the engaged, general reader alike.

The mainstream view of the immune system is concerned with molecular and cellular details resulting in a picture of immense complexity. Many immunologists live with this complexity, hoping that a series of breakthroughs will eventually add up to a greater insight. However, the forest is ignored for the trees and a ‘Systems Approach’ is vital for a better understanding. Peter Bretscher develops here a unique perspective on how the immune system functions as an integrated organ, by taking account of observations and concepts at the ‘level of system’ that are often half forgotten or ignored. A colleague, on reading this book, wrote: “Those who have followed Peter’s work these past 50 years will recognize this book for what it really is — a rare achievement, a scientific masterpiece. It is a must read for all those Immunologists and Clinicians who want to find effective immunological cures for the many debilitating health issues that confront us. Peter Bretscher has produced a lucid and logical exposition of the rules governing how the adaptive immune system responds to all foreign antigens whether bacterial, viral or modifications of the self, which emerge in cancer or autoimmune conditions. This book is a testament to Louis Pasteur’s dictum that there is no applied science, just the application of basic science.” Rediscovering the Immune System is written in a jargon-free and accessible style. This personal perspective is an ideal guide to the immune system for students, researchers and the engaged, general reader alike.

Machine generated contents note: -- Preface -- Acknowledgements -- Introduction -- Chapter 1: A History of the Immune Self -- Chapter 2: Whither Immune Identity? -- Chapter 3: Individuality Revised -- Chapter 4: Immune Cognition -- Chapter 5: Eco-immunology -- Chapter 6: A New Biology? -- Epilogue -- Endnotes -- References. 650

In The Foundations of Immunology and their Pertinence to Medicine, Peter Bretscher describes how the few foundational concepts of immunology came about. He traces Jenner's development of safe vaccination against small pox in the 1700's, and how it led to the recognition of infectious disease by Koch and Pasteur in the 1880's, and to the discovery of the Principles of Vaccination. The formulation of the Clonal Selection Theory in the 1950's still provides a foundation for contemporary analysis of the immune system. Peter describes the main, and sometimes conflicting concepts, proposed in the last 50 years as to how immune responses are regulated. He develops a unique framework, and employs this to justify some tested and some speculative strategies to prevent and treat clinical conditions in five areas of medicine: Infectious Diseases, Cancer, Autoimmunity, Allergies and Transplantation. This book provides a platform for discussing contemporary immunological issues accessible to the non-specialist, medical students and medical practitioners. The platform challenges some of todays most popular paradigms. Foundations is written in a clear and jargon-free style.

In The Foundations of Immunology and their Pertinence to Medicine, Peter Bretscher describes how the few foundational concepts of immunology came about. He traces Jenner’s development of safe vaccination against small pox in the 1700’s, and how it led to the recognition of infectious disease by Koch and Pasteur in the 1880’s, and to the discovery of the Principles of Vaccination. The formulation of the Clonal Selection Theory in the 1950’s still provides a foundation for contemporary analysis of the immune system. Peter describes the main, and sometimes conflicting concepts, proposed in the last 50 years as to how immune responses are regulated. He develops a unique framework, and employs this to justify some tested and some speculative strategies to prevent and treat clinical conditions in five areas of medicine: Infectious Diseases, Cancer, Autoimmunity, Allergies and Transplantation. This book provides a platform for discussing contemporary immunological issues accessible to the non-specialist, medical students and medical practitioners. The platform challenges some of todays most popular paradigms. Foundations is written in a clear and jargon-free style.

Get a solid, global foundation of the therapies and evidence-based clinical applications of CAI. Fundamentals of Complementary, Alternative, and Integrative Medicine, 6th Edition is filled with the most up-to-date information on scientific theory and research of holistic medicine from experts around the world. The 6th edition of this acclaimed text includes all new content on quantum biology and biofields in health and nursing, integrative mental health care, and homeopathic medicine. Its wide range of topics explores therapies most commonly seen in the U.S., such as energy medicine, mind-body therapies, and reflexology along with traditional medicine and practices from around the world. With detailed coverage of historic and contemporary applications, this text is a solid resource for all practitioners in the medical, health, and science fields! Coverage of CAI therapies and systems includes those most commonly encountered or growing in popularity, so you can carefully evaluate each treatment. An evidence-based approach focuses on treatments best supported by clinical trials and scientific evidence. Observations from mechanisms of action to evidence of clinical efficacy answers questions of how, why, and when CAM therapies work. A unique synthesis of information, including historical usage, cultural and social analysis, current basic science theory and research, and a wide range of clinical investigations and observations, makes this text a focused, authoritative resource. Global coverage includes discussions of traditional healing arts from Europe, Asia, Africa, and the Americas. Clinical guides for selecting therapies, and new advances for matching the appropriate therapy to the individual patient, enables you to offer and/or recommend individualized patient care. Expert contributors include well-known writers such as Kevin Ergil, Patch Adams, Joseph Pizzorno, and Marc Micozzi. A unique history of CAI traces CAM therapies from their beginnings to present day practices. Suggested readings and references on the companion website list the best resources for further research and study. NEW! Added chapters offer fresh perspective on quantum biology and biofields in health and nursing, integrative mental health care, and homeopathic medicine. NEW! Updated chapters feature new content and topics, including: challenges in integrative medicine, legal issues, CAI in the community, psychometric evaluation, placebo effect, stress management, and much more! NEW! Updated guides on common herbal remedies in clinical practice, East and Southeast Asia, and native North and South America deliver the latest information. NEW! Basic science content and new theory and research studies cover a wide range of sciences such as biophysics, biology and ecology, ethnomedicine, psychometrics, neurosciences, and systems theory. NEW! Expanded global ethnomedical systems includes new content on Shamanism and Neo-Shamanism, Central and North Asia, Southeast Asia, Nepal and Tibet, Hawaii and South Pacific, Alaska and Pacific Northwest, and contemporary global healthcare.

Recent neuroscience research makes it clear that human biology is cultural biology - we develop and live our lives in socially constructed worlds that vary widely in their structure values, and institutions. This integrative volume brings together interdisciplinary perspectives from the human, social, and biological sciences to explore culture, mind, and brain interactions and their impact on personal and societal issues. Contributors provide a fresh look at emerging concepts, models, and applications of the co-constitution of culture, mind, and brain. Chapters survey the latest theoretical and methodological insights alongside the challenges in this area, and describe how these new ideas are being applied in the sciences, humanities, arts, mental health, and everyday life. Readers will gain new appreciation of the ways in which our unique biology and cultural diversity shape behavior and experience, and our ongoing adaptation to a constantly changing world.