This issue of the Obstetrics and Gynecology Clinics in North America will focus on the advances in the evaluation and management of Recurrent Pregnancy Loss (RPL) that have emerged within the last few years. Although spontaneous pregnancy loss occurs in approximately 15% to 20% of clinically recognized pregnancies in reproductive-aged women, RPL occurs in 2% to 5% of the same population. Recent reports on large populations of women with RPL have helped to characterize the incidence and diversity of this heterogeneous disorder, and a definite cause of pregnancy loss can be established on over 50% of all couples after a thorough evaluation. New diagnostic strategies, which include 23-chromosome microarray genetic testing of the products of conception in failed pregnancies, offer the promise of understanding the cause of most pregnancy losses. These recent advances, combined with the contributions from the authors in this issue of Clinics and many others interested in this field, lead to the publication of the long-awaited publication on evaluation and treatment of RPL from the Practice Committee of the American Society for Reproductive Medicine. A complete evaluation will include investigations into genetic, anatomic, immunologic, endocrinologic, and iatrogenic factors.

This book provides up to date reviews on disease management, techniques and procedures, and technology. Beginning with an introduction, the following chapters examine different conditions that may cause or contribute to recurrent miscarriage, such as obesity, endometritis and genetic causes; and then discuss the role of IVF and pre-implantation genetic screening. With contributions from international specialists in the UK, USA and India, this book includes numerous images and illustrations to enhance learning.

Providing the latest evidence-based information on etiology, evaluation and treatment, this unique text provides an in-depth, comprehensive discussion of the epidemiology, genetic and endocrinologic factors and medical and surgical management of recurrent pregnancy loss (RPL). Taking a multidisciplinary approach including psychological treatment and patient perspectives, all aspects of current RPL prevention and treatment are elucidated. Detailed chapters provide real-world illustrative material and cover the set-up and management of RPL clinics and databases, containing practical tips. Recurrent Pregnancy Loss will be an excellent resource for OB-GYN specialists, general and reproductive endocrinologists, radiologists, hematologists, psychiatrists, psychologists, and any other investigators or clinicians treating patients confronted with this emotionally and physically trying condition.

This new edition presents obstetricians and trainees with the most recent developments and research associated with recurrent spontaneous miscarriages. Beginning with an overview, the next chapter covers ultrasonographic features of foetal demise. The following sections discuss different causes of recurrent miscarriage – anatomical, immunological, genetic, endocrinal, endometriosis, and infections. The book explains aspects of obstetric vasculopathies and includes frequently asked questions on the use of heparin, progesterone, HCG, and other supplements. A complete chapter is dedicated to the psychological effects of recurrent spontaneous miscarriages. The third edition features new topics, clinical images and extensive references. Key points Fully revised, third edition presenting latest information on recurrent spontaneous miscarriages Covers many different causes of recurrent miscarriage Includes FAQs on use of supplements Previous edition (9789351521778) published in 2014

This book covers the entire topic of recurrent miscarriage extensively. Chapters cover demographics to recent and future management options. A special section on the role of controversial strategies has also been included. Lastly, the book features dedicated chapters on evidence-based approaches, which include step-by-step algorithms for the reader’s convenience.

Exploring basic science and the clinical applications, Recurrent Pregnancy Loss: Causes, Controversies and Treatment provides an authoritative, comprehensive review of the management of recurrent pregnancy loss. Many subjects in this area are controversial, and occasionally clinical decisions are based on lack of knowledge rather than evidence. For this reason, chapters include debates by leading experts to aid the clinician in deciding on the appropriate clinical management. Chapters cover basic science, genetics, and the application of evidence based medicine as well as mid- trimester loss, late obstetric complications, and related psychological mechanisms. This book will be essential reading for specialists working in recurrent pregnancy loss clinics and associated disciplines, as well as anyone wishing to gain a comprehensive view of developments in the field.