Recommended Guideline for Acute Oral Toxicity Testing in Rodents
Title | Recommended Guideline for Acute Oral Toxicity Testing in Rodents PDF eBook |
Author | |
Publisher | |
Pages | |
Release | 1981 |
Genre | |
ISBN |
OECD Guidelines for Testing of Chemicals
Title | OECD Guidelines for Testing of Chemicals PDF eBook |
Author | Organisation for Economic Co-operation and Development |
Publisher | Organisation for Economic Co-operation and Development ; [Montréal : Renouf] |
Pages | |
Release | 1981 |
Genre | Chemical industry |
ISBN | 9789264122215 |
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 408: Repeated Dose 90-Day Oral Toxicity Study in Rodents
Title | OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 408: Repeated Dose 90-Day Oral Toxicity Study in Rodents PDF eBook |
Author | OECD |
Publisher | OECD Publishing |
Pages | 16 |
Release | 2018-06-27 |
Genre | |
ISBN | 9264070702 |
This method provides information on health hazard likely to arise from exposure to test substance via oral administration. The determination of sub-chronic oral toxicity using repeated doses may be carried out after initial information on toxicity has been obtained from acute or repeated dose ...
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 423: Acute Oral toxicity - Acute Toxic Class Method
Title | OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 423: Acute Oral toxicity - Acute Toxic Class Method PDF eBook |
Author | OECD |
Publisher | OECD Publishing |
Pages | 14 |
Release | 2002-02-08 |
Genre | |
ISBN | 9264071008 |
This is a test guideline for testing for Acute Oral Tosxidity using the Acute Toxic Class Method.
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure
Title | OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure PDF eBook |
Author | OECD |
Publisher | OECD Publishing |
Pages | 14 |
Release | 2002-02-08 |
Genre | |
ISBN | 926407094X |
A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use with rat. Groups of animals of a ...
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 452: Chronic Toxicity Studies
Title | OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 452: Chronic Toxicity Studies PDF eBook |
Author | OECD |
Publisher | OECD Publishing |
Pages | 18 |
Release | 2018-06-27 |
Genre | |
ISBN | 9264071202 |
The objective of these chronic toxicity studies is to characterize the profile of a substance in a mammalian species (primarily rodents) following prolonged and repeated exposure. The Test Guideline focuses on rodents and oral administration. Both ...
Handbook of Acute Oral Toxicity Testing Method
Title | Handbook of Acute Oral Toxicity Testing Method PDF eBook |
Author | Swapnil Satish Khadke |
Publisher | LAP Lambert Academic Publishing |
Pages | 76 |
Release | 2011-09 |
Genre | |
ISBN | 9783845477831 |
The purposes of acute toxicity testing are to obtain information on the biologic activity of a chemical and gain insight into its mechanism of action. The information on acute systemic toxicity generated by the test is used in hazard identification and risk management in the context of production, handling, and use of chemicals. For a classical LD50 study, laboratory mice and rats are the species typically selected. This book gives a short review of methods for acute toxicity testing with the emphasis on the Up and Down Method as per OECD Guidelines 425. Furthermore, this book consist of one research work on acute oral toxicity studies performed by authors.