This book is to improve our understanding of mechanisms leading to seizures in humans and in developing new therapeutic options. The book covers topics such as recent approaches to seizure control, recent developments in signal processing of interest for seizure prediction, ictogenesis in complex epileptic brain networks, active probing of the pre-seizure state, non-EEG based approaches to the transition to seizures, microseizures and their role in the generation of clinical seizures, the impact of sleep and long-biological cycles on seizure prediction, as well as animal and computational models of seizures and epilepsy. Furthermore the book covers recent developments of international databases and of parallel computing structures based on Cellular Nonlinear Networks that can play an important role in the realization of a portable seizure warning device.

Clinical applications of neurostimulation or neuromodulation are experiencing rapid growth, driven by an evolution in neurotechnologies, the limitations of pharmacotherapy, and an improving understanding of brain physiology. New methods are promising for intractable or marginally tractable cognitive diseases and for adjunct therapies, as they offer greatly improved spatial and temporal resolution, thereby promising greater specificity and quicker recovery from disease. This book includes up-to-date and in-depth studies of many of these therapies, with chapters addressing their use in epilepsy, spasticity, pain, neurodegeneration, and spinal cord dysfunctions, among others, illustrating their versatility and therapeutic promise for cognitive dysfunction.

With the recent development of new technology and practices in the field of ambulatory EEG (aEEG), the time is right for a practical reference on the application of aEEG in clinical practice. This authoritative guide to prolonged EEG recording outside the hospital or clinic is a valuable resource for anyone involved in long-term EEG monitoring and interpretation. Bridging the gap between routine scalp EEG and in-patient video EEG monitoring, aEEG has evolved to provide cost-effective, high-yield, high-tech recording for evaluation of epilepsy diagnoses, nonepileptic attacks, quantification of seizures or epileptiform burden, and other issues requiring extended EEG observation for paroxysmal neurological events in any environment. Bringing together top experts from leading epilepsy centers, the book covers equipment, technical aspects of recording, instrumentation and polygraphic event monitoring, artifacts, clinical use in adult and pediatric patients, sleep recording, short-term and chronic ambulatory EEG, and reimbursement. The concluding chapter offers representative case presentations with relevant findings to further enhance the reader’s understanding and implementation of key concepts. This "start to stop" survey of current applications is essential reading for a wide range of clinicians practicing in the field of clinical neurophysiology and epilepsy management, whether seasoned or in training. Key Features: Fills the void of when and how to use aEEG in evaluating patients with paroxysmal neurological events and epilepsy Incorporates aEEG into clinical management at all stages of diagnosis and treatment Contains numerous aEEG illustrations and graphics to emphasize key points Includes a chapter on common artifacts that can complicate the interpretation of an aEEG Details the evolving use of chronic intracranial aEEG and wearable devices Illustrative case studies provide pearls and reinforce best practices in aEEG monitoring

This open access book constitutes the refereed proceedings of the 17th International Conference on String Processing and Information Retrieval, ICOST 2019, held in New York City, NY, USA, in October 2019. The 15 full papers and 5 short papers presented in this volume were carefully reviewed and selected from 24 submissions. They cover topics such as: e-health technology design; well-being technology; biomedical and health informatics; and smart environment technology.

Epilepsy, one of the most prevalent neurological disorders, affects approximately 1% (greater than 60 million) of the world's population. In an estimated 20 million of these patients, seizures are not controlled even by multiple anti-seizure drugs, and are extremely difficult to predict. Epilepsy: The Intersection of Neurosciences, Biology, Mathema

The pharmacological fight against epilepsy began many centuries ago when Hippocrates discovered that the cause of epilepsy is natural, as opposed to supernatural and, as a consequence, must be treated with a natural remedy. Even though science has significantly progressed since that era, the challenge to find remedies for epilepsy is ever present. The aim of this particular volume is to offer an up-to-date review of the most recent advances in antiepileptic drug development, considered from various viewpoints: (i) general, by taking into account the size of refractory epilepsy and its related problems; (ii) experimental, by exploring the mechanisms of epileptogenesis and the possiblility of influencing it through drugs, and (iii) clinical, by describing the results obtained with compounds currently at an advanced stage of testing.