The biologic effects of radiation on normal tissues and tumors represent a complex area for investigation. These effects are of far-reaching consequence to the diagnostic radiologist and the radiation oncologist having a significant impact not only in concepts relative to radiation protection but also in concepts relative to tumor biology and its response to radiation injury. The volume edited by SCHERER, STREFFER, and TROTT represents an extension of basic radiation biology data into the effects of radiation in producing pathology in organs and tissues. The data presented by the multiple authors involved in this text cover essentially all tissues in the body with specific definition of radiopathology changes and their impact on clinical care of the patient. This volume represents an important and significant contribution toward a better understanding of these effects and the pathology produced by radiations. L. W. BRADY H.-P. HEILMANN F. HEUCK M. W. DONNER Philadelphia Hamburg Stuttgart Baltimore Preface This book represents an attempt to describe the clinical radiobiology of complications arising in different organs after radiotherapy of cancer patients. Since by their very nature malignant tumors infiltrate the organ in which they have arisen and the neighboring tissues, curative radiotherapy requires the planned irradiation of considerable amounts of healthy but potentially or microscopically involved normal tissues and organs with the full target dose. This may lead to early or late normal tissue radiation injury.

This volume covers all aspects of side effects in radio-oncological treatment of tumors, and of combined, multi-modal therapies. Recent developments as well as future perspectives in radiation biology of acute and late responding normal tissues are included. Special focus is given to more general treatment effects, such as anaemia, fatigue and impairment of quality of life, and post-treatment rehabilitation requirements. The book illuminates forensic aspects of radiation therapy and related complications; it further exemplifies incidence, documentation, and clinical management approaches for side effects as well as novel cyto-/tissue-protective strategies. Particular features of side effects after stereotactic or radiosurgical treatment of brain tumors, unconventional irradiation protocols for head and neck tumors, and conformal radiotherapy for prostate tumors are illustrated and followed by discussions of an optimization of physical treatment planning, e.g. by intensity modulation techniques. Bringing together medical, biological, molecular and physical expertise, research in the field of radiation-induced side effects is a true interdisciplinary effort. This publication will therefore be of great value to biologists, physicists and physicians of all disciplines involved in radio-oncological and multi-modal tumor therapy.

Biologists and radiotherapists present their experimental work and clinical data in the field of radiation injuries of normal tissues and organs. Particular regard is payed to the relevance of biological mechanisms in clinical situations. Principles of radiation damage and combined treatment toxicity in radio-chemotherapy are being explained. The main topics discussed are the importance of microvasculature, time, doseand fractionation and factors modifying clinical radioresponse for early andlate radiation effects. Tissues and organs considered in this volume are mucosa and skin, lung and heart, bladder and muscle, CNS and eye. Special problems of pediatric radiotherapy, TBI, IORT and second malignacies are also mentioned.

Pathology Illustrated presents both general and systematic pathology in a highly visual style. This format makes the essential information more accessible and memorable.

Get the BIG PICTURE of Pathology - and focus on what you really need to know to score high on the course and board exam If you want a streamlined and definitive look at Pathology - one with just the right balance of information to give you the edge at exam time - turn to Pathology: The Big Picture. You'll find a succinct, user-friendly presentation especially designed to make even the most complex concept understandable in the shortest amount of study time possible. This perfect pictorial and textual overview of Pathology delivers: A “Big Picture” emphasis on what you must know verses “what's nice to know” Expert authorship by award-winning, active instructors Coverage of the full range of pathology topics - everything from cellular adaptations and injury to genetic disorders to inflammation to diseases of immunity Magnificent 4-color illustrations Numerous summary tables and figures for quick reference and rapid retention of even the most difficult topic Highlighted key concepts that underscore integral aspects of histology (key concepts are also listed in a table at the end of each chapter) USMLE-type questions, answers, and explanations to help you anticipate what you'll encounter on the exams And much more!

A unique case-based molecular approach to understanding pathology Pathology: A Modern Case Study is a concise, focused text that emphasizes the molecular and cellular biology essential to understanding the concepts of disease causation. The book includes numerous case studies designed to highlight the role of the pathologist in the team that provides patient care. Pathology: A Modern Case Study examines the role of anatomic, clinical, and molecular pathologists in dedicated chapters and in descriptions of the pathology of specific organ systems. Features Coverage of pathology focuses on modern approaches to common and important diseases Each chapter delivers the most up-to-date advances in pathology Learning aids include chapter summaries and overviews, bolded terms, and a glossary Common clinically relevant disease are highlighted Disease discussion is based on organ compartment and etiology Coverage includes: Disease and the Genome: Genetic, Developmental and Neoplastic Disease Cell Injury, Death and Aging and the Body's Response Environmental Injury Clinical Practice: Anatomic Pathology Clinical Practice: Molecular Pathology Clinical Practice: Molecular Pathology Organ-specific pathology covering all major body systems Molecular pathology Essential for undergraduate medical students and clinicians who wish to expand their knowledge pathology, Pathology: A Modern Case Study delivers valuable coverage that is directly related to a patient’s condition and the clinical practice of pathology.