Quantum Tunnelling in Enzyme-catalysed Reactions

Quantum Tunnelling in Enzyme-catalysed Reactions
Title Quantum Tunnelling in Enzyme-catalysed Reactions PDF eBook
Author Rudolf K. Allemann
Publisher Royal Society of Chemistry
Pages 412
Release 2009
Genre Science
ISBN 0854041222

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In recent years, there has been an explosion in knowledge and research associated with the field of enzyme catalysis and H-tunneling. Rich in its breath and depth, this introduction to modern theories and methods of study is suitable for experienced researchers those new to the subject. Edited by two leading experts, and bringing together the foremost practitioners in the field, this up-to-date account of a rapidly developing field sits at the interface between biology, chemistry and physics. It covers computational, kinetic and structural analysis of tunnelling and the synergy in combining these methods (with a major focus on H-tunneling reactions in enzyme systems). The book starts with a brief overview of proton and electron transfer history by Nobel Laureate, Rudolph A. Marcus. The reader is then guided through chapters covering almost every aspect of reactions in enzyme catalysis ranging from descriptions of the relevant quantum theory and quantum/classical theoretical methodology to the description of experimental results. The theoretical interpretation of these large systems includes both quantum mechanical and statistical mechanical computations, as well as simple more approximate models. Most of the chapters focus on enzymatic catalysis of hydride, proton and H" transfer, an example of the latter being proton coupled electron transfer. There is also a chapter on electron transfer in proteins. This is timely since the theoretical framework developed fifty years ago for treating electron transfers has now been adapted to H-transfers and electron transfers in proteins. Accessible in style, this book is suitable for a wide audience but will be particularly useful to advanced level undergraduates, postgraduates and early postdoctoral workers.

Principles of Thermal Ecology

Principles of Thermal Ecology
Title Principles of Thermal Ecology PDF eBook
Author Andrew Clarke
Publisher Oxford University Press
Pages 497
Release 2017
Genre Science
ISBN 0199551669

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This is the first single volume to cover the effect of temperature in its entirety. The threat of rapid climatic change on a global scale is a stark reminder of the challenges that remain for evolutionary thermal biologists, and adds a sense of urgency to this book's mission.

Kinetics and Dynamics

Kinetics and Dynamics
Title Kinetics and Dynamics PDF eBook
Author Piotr Paneth
Publisher Springer Science & Business Media
Pages 538
Release 2010-08-03
Genre Science
ISBN 9048130344

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"Kinetics and Dynamics" on molecular modeling of dynamic processes opens with an introductory overview before discussing approaches to reactivity of small systems in the gas phase. Then it examines studies of systems of increasing complexity up to the dynamics of DNA. This title has interdisciplinary character presenting wherever possible an interplay between the theory and the experiment. It provides basic information as well as the details of theory and examples of its application to experimentalists and theoreticians interested in modeling of dynamic processes in chemical and biochemical systems. All contributing authors are renowned experts in their fields and topics covered in this volume represent the forefront of today’s science.

Theory and Applications of the Empirical Valence Bond Approach

Theory and Applications of the Empirical Valence Bond Approach
Title Theory and Applications of the Empirical Valence Bond Approach PDF eBook
Author Fernanda Duarte
Publisher John Wiley & Sons
Pages 139
Release 2017-04-17
Genre Science
ISBN 1119245397

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A comprehensive overview of current empirical valence bond (EVB) theory and applications, one of the most powerful tools for studying chemical processes in the condensed phase and in enzymes. Discusses the application of EVB models to a broad range of molecular systems of chemical and biological interest, including reaction dynamics, design of artificial catalysts, and the study of complex biological problems Edited by a rising star in the field of computational enzymology Foreword by Nobel laureate Arieh Warshel, who first developed the EVB approach

Visions of the Future: Chemistry and Life Science

Visions of the Future: Chemistry and Life Science
Title Visions of the Future: Chemistry and Life Science PDF eBook
Author J. M. T. Thompson
Publisher Cambridge University Press
Pages 212
Release 2001-07-12
Genre Science
ISBN 9780521805391

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Leading young scientists give engaging reviews of their research areas and exciting visions of future developments.

Computational Approaches for Studying Enzyme Mechanism Part A

Computational Approaches for Studying Enzyme Mechanism Part A
Title Computational Approaches for Studying Enzyme Mechanism Part A PDF eBook
Author
Publisher Academic Press
Pages 560
Release 2016-08-04
Genre Science
ISBN 0128053631

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Computational Approaches for Studying Enzyme Mechanism Part A, is the first of two volumes in the Methods in Enzymology series, focusses on computational approaches for studying enzyme mechanism. The serial achieves the critically acclaimed gold standard of laboratory practices and remains one of the most highly respected publications in the molecular biosciences. Each volume is eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 550 volumes, the series remains a prominent and essential publication for researchers in all fields of life sciences and biotechnology, including biochemistry, chemical biology, microbiology, synthetic biology, cancer research, and genetics to name a few. - Focuses on computational approaches for studying enzyme mechanism - Continues the legacy of this premier serial with quality chapters authored by leaders in the field - Covers research methods in intermediate filament associated proteins, and contains sections on such topics as lamin-associated proteins, intermediate filament-associated proteins and plakin, and other cytoskeletal cross-linkers

Biomolecular Kinetics

Biomolecular Kinetics
Title Biomolecular Kinetics PDF eBook
Author Clive R. Bagshaw
Publisher CRC Press
Pages 446
Release 2017-10-04
Genre Medical
ISBN 1498727247

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"a gem of a textbook which manages to produce a genuinely fresh, concise yet comprehensive guide" –Mark Leake, University of York "destined to become a standard reference.... Not just a ‘how to’ handbook but also an accessible primer in the essentials of kinetic theory and practice." –Michael Geeves, University of Kent "covers the entire spectrum of approaches, from the traditional steady state methods to a thorough account of transient kinetics and rapid reaction techniques, and then on to the new single molecule techniques" –Stephen Halford, University of Bristol This illustrated treatment explains the methods used for measuring how much a reaction gets speeded up, as well as the framework for solving problems such as ligand binding and macromolecular folding, using the step-by-step approach of numerical integration. It is a thoroughly modern text, reflecting the recent ability to observe reactions at the single-molecule level, as well as advances in microfluidics which have given rise to femtoscale studies. Kinetics is more important now than ever, and this book is a vibrant and approachable entry for anyone who wants to understand mechanism using transient or single molecule kinetics without getting bogged down in advanced mathematics. Clive R. Bagshaw is Emeritus Professor at the University of Leicester, U.K., and Research Associate at the University of California at Santa Cruz, U.S.A.