This issue on sex and gender comes at an opportune time, as the DSM-IV is being revised, and in particular sex and gender issues are being reconsidered. This issue focuses on research in the area of gender variant children and transgender adolescents, assessment of several scenarios and clear information on practice parameters. Therapy for gender variant children and transgender adolescents is discussed in detail, as well as parents' perspectives, ethical legal, and non-discrimination issues, and education on these subjects. International standards of care are also discussed.

This issue of Anesthesiology Clinics focuses on Quality Improvement and Implementation Science, with topics including: Applying implementation science principles to perioperative care; Emergency checklists in perioperative care; Human factors applied to perioperative process improvement; Handoffs in perioperative care; Use of simulation in performance improvement; Developing capacity to do improvement science work; Developing multicenter registries to advance quality science; Rethinking clinical workflow; data-driven quality improvement; and Scaling quality improvement at the health system level.

This issue of Anesthesiology Clinics covers essential topics in the post anesthesia care unit. Management of pain, delirium, acute renal failure, arrhythmias, and several post anesthesia complications are covered. Both adult and pediatric issues are addressed.

This issue will cover novel approaches to demonstrating value by anesthesiologists. Articles will include Value from the Patient and Payer Perspectives, Perioperative Surgical Home, Demonstrating Value: A British perspective, Demonstrating value: A case study of enhanced recovery, Acute Pain Management/Regional, Measuring Outcomes as Demonstrating Value and many more!

This issue of Anesthesiology Clinics, edited by Dr. Michael T. Walsh in collaboration with Consulting Editor Lee Fleisher, is focused on Ambulatory Anesthesia. Topics in this issue include: Preoperative evaluation for ambulatory anesthesia; Obesity and obstructive sleep apnea in the ambulatory patient; Pediatric ambulatory anesthesia challenges; Safety in dental anesthesia for office-based practitioners; Office-based anesthesia; Regional anesthesia for the ambulatory anesthesiologist; Anesthesia for same-day total joint; Enhanced recovery in outpatient surgery; Outcomes in ambulatory anesthesia: Measuring what matters; ASC Medical director issues; NORA: Anesthesia in the GI suite; MACRA/MIPS/APM, etc: Payment issues in ambulatory anesthesia; Emergency response in the ASC; and Quality Improvement in ambulatory anesthesia.