Upton, New York, 10-14 September 2007

TRR no. 2014 includes 12 papers that explore the modeling of learning in route choice, the modeling of household vehicle transaction behavior, analysis of 28-day global positioning system panel survey, attitudes toward risk in discrete choice models, and defining sampling districts for household travel surveys, and day-to-day travel variability. This issue of the TRR also examines multimodal choice set generation, gender in time allocation, observed behavioral dynamics of baby boomers and regional travel demand models, trends in out-of-home and at-home activities, creating synthetic household populations, and population synthesis for microsimulating travel behavior.

Many researchers from different countries converged at the 10th Italian Conference on Theoretical Computer Science (ICTCS 2007) to discuss recent developments in theoretical computer science. The volume contains all contributed papers selected for presentation with the invited lectures delivered. The subjects of this book range from logical and mathematical aspects of computing, design and analysis of algorithms, to semantics of programming languages. Sample Chapter(s). Part A: Invited Talks: Clairvoyance and Laziness for on Line Travelling Agents (27 KB). Contents: Clairvoyance and Laziness for on Line Travelling Agents (G Ausiello); Symmetries in Foundations (G Longo); On the Approximability of Dense Steiner Tree Problems (M Hauptmann); Analyzing Non-Inteference with Respect to Classes (D Zanardini); Modeling Fuzzy Behaviours in Concurrent Systems (L D''Errico & M Loreti); Sorting Streamed Multisets (T Gagie); Dichotomy Results for Fixed Point Counting in Boolean Dynamical Systems (S Kosub & C M Homan); Definable Sets in Weak Presburger Arithmetic (C Choffrut & A Frigeri); and other papers. Readership: Theoretical computer scientists.

Edited by internationally recognized authorities in the field, this expanded and updated new edition of the bestselling Handbook, containing more than 100 new articles, is aimed at the design and operation of modern particle accelerators. It is intended as a vade mecum for professional engineers and physicists engaged in these subjects. With a collection of more than 2000 equations, 300 illustrations and 500 graphs and tables, here one will find, in addition to the common formulae of previous compilations, hard-to-find, specialized formulae, recipes and material data pooled from the lifetime experience of many of the world''s most able practitioners of the art and science of accelerators.The eight chapters include both theoretical and practical matters as well as an extensive glossary of accelerator types. Chapters on beam dynamics and electromagnetic and nuclear interactions deal with linear and nonlinear single particle and collective effects including spin motion, beam-environment, beam-beam, beam-electron, beam-ion and intrabeam interactions. The impedance concept and related calculations are dealt with at length as are the instabilities associated with the various interactions mentioned. A chapter on operational considerations includes discussions on the assessment and correction of orbit and optics errors, real-time feedbacks, generation of short photon pulses, bunch compression, tuning of normal and superconducting linacs, energy recovery linacs, free electron lasers, cooling, space-charge compensation, brightness of light sources, collider luminosity optimization and collision schemes. Chapters on mechanical and electrical considerations present material data and important aspects of component design including heat transfer and refrigeration. Hardware systems for particle sources, feedback systems, confinement and acceleration (both normal conducting and superconducting) receive detailed treatment in a subsystems chapter, beam measurement techniques and apparatus being treated therein as well. The closing chapter gives data and methods for radiation protection computations as well as much data on radiation damage to various materials and devices.A detailed name and subject index is provided together with reliable references to the literature where the most detailed information available on all subjects treated can be found.

The topics covered in the conference ranged from the physics that can be done with polarized beams of particles (protons, electrons, gamma-rays, etc.) to the techniques and instrumentation necessary to achieve this. Topics included: nucleon structure measurements (from where does the spin of the proton and neutron come), the acceleration, storage and polarization of particle beams and the polarized targets and sources necessary for mounting the experiments.

Newport News, Virginia, 25-27 March 2009

Post-translational modifications (PTMs) are widely employed by all living organisms to control the enzymatic activity, localization or stability of proteins on a much shorter time scale than the transcriptional control. In eukarya, global analyses consistently reveal that proteins are very extensively phosphorylated, acetylated and ubiquitylated. Glycosylation and methylation are also very common, and myriad other PTMs, most with a proven regulatory potential, are being discovered continuously. The emergent picture is that PTM sites on a single protein are not independent; modification of one residue often affects (positively or negatively) modification of other sites on the same protein. The best example of this complex behavior is the histone “bar-code” with very extensive cross-talk between phosphorylation, acetylation and methylation sites. Traditionally it was believed that large networks of PTMs exist only in complex eukaryal cells, which exploit them for coordination and fine-tuning of various cellular functions. PTMs have also been detected in bacteria, but the early examples focused on a few important regulatory events, based mainly on protein phosphorylation. The global importance (and abundance) of PTMs in bacterial physiology was systematically underestimated. In recent years, global studies have reported large datasets of phosphorylated, acetylated and glycosylated proteins in bacteria. Other modifications of bacterial proteins have been recently described: pupylation, methylation, sirtuin acetylation, lipidation, carboxylation and bacillithiolation. As the landscape of PTMs in bacterial cells is rapidly expanding, primarily due to advances of detection methods in mass spectrometry, our research field is adapting to comprehend the potential impact of these modifications on the cellular physiology. The field of protein phosphorylation, especially of the Ser/Thr/Tyr type, has been profoundly transformed. We have become aware that bacterial kinases phosphorylate many protein substrates and thus constitute regulatory nodes with potential for signal integration. They also engage in cross-talk and eukaryal-like mutual activation cascades. The regulatory potential of protein acetylation and glycosylation in bacteria is also rapidly emerging, and the cross-talk between acetylation and phosphorylation has been documented. This topic deals with the complexity of the PTM landscape in bacteria, and focus in particular on the physiological roles that PTMs play and methods to study them. The topic is associated to the 1st International Conference on Post-Translational Modifications in Bacteria (September 9-10, 2014, Göttingen, Germany).