Protein Structure, Stability, and Interactions
Title | Protein Structure, Stability, and Interactions PDF eBook |
Author | John W. Shriver |
Publisher | Humana |
Pages | 0 |
Release | 2010-11-19 |
Genre | Science |
ISBN | 9781617378553 |
In the areas of biochemistry and cell biology, characterizations of stability and molecular interactions call for a quantitative approach with a level of precision that matches the fine tuning of these interactions in a living cell. Supporting and up-dating previous Methods in Molecular BiologyTM volumes, Protein Structure, Stability, and Interactions approaches its subject with a focus on theory and practical applications for both established methods as well as exciting new procedures. The volume presents an overview of many techniques currently used to study protein stability and interactions, including scanning and titration calorimetry, spectroscopic methods, high field NMR, and analytical ultracentrifugation. As a volume of the highly successful Methods in Molecular BiologyTM series, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Cutting-edge and easy to reference, Protein Structure, Stability, and Interactions is an ideal guide for all scientists interested in biomolecular interactions.
Protein Structure, Stability, and Folding
Title | Protein Structure, Stability, and Folding PDF eBook |
Author | Kenneth P. Murphy |
Publisher | Springer Science & Business Media |
Pages | 258 |
Release | 2008-02-04 |
Genre | Science |
ISBN | 1592591930 |
In Protein Structure, Stability, and Folding, Kenneth P. Murphy and a panel of internationally recognized investigators describe some of the newest experimental and theoretical methods for investigating these critical events and processes. Among the techniques discussed are the many methods for calculating many of protein stability and dynamics from knowledge of the structure, and for performing molecular dynamics simulations of protein unfolding. New experimental approaches presented include the use of co-solvents, novel applications of hydrogen exchange techniques, temperature-jump methods for looking at folding events, and new strategies for mutagenesis experiments. Unique in its powerful combination of theory and practice, Protein Structure, Stability, and Folding offers protein and biophysical chemists the means to gain a more comprehensive understanding of some of this complex area by detailing many of the major techniques in use today.
Molecular Biology of The Cell
Title | Molecular Biology of The Cell PDF eBook |
Author | Bruce Alberts |
Publisher | |
Pages | 0 |
Release | 2002 |
Genre | Cytology |
ISBN | 9780815332183 |
Methods in Protein Structure and Stability Analysis: Conformational stability, size, shape, and surface of protein molecules
Title | Methods in Protein Structure and Stability Analysis: Conformational stability, size, shape, and surface of protein molecules PDF eBook |
Author | Vladimir N. Uversky |
Publisher | Nova Publishers |
Pages | 414 |
Release | 2007 |
Genre | Science |
ISBN | 9781600217043 |
Protein research is a frontier field in science. Proteins are widely distributed in plants and animals and are the principal constituents of the protoplasm of all cells, and consist essentially of combinations of a-amino acids in peptide linkages. Twenty different amino acids are commonly found in proteins, and serve as enzymes, structural elements, hormones, immunoglobulins, etc., and are involved throughout the body, and in photosynthesis. This book gathers new leading-edge research from throughout the world in this exciting and exploding field of research.
Protein Stability
Title | Protein Stability PDF eBook |
Author | David S. Eisenberg |
Publisher | |
Pages | 334 |
Release | 1995 |
Genre | Science |
ISBN | 9780120342464 |
The topics covered by this volume include: protein destabilization at low temperatures; engineering the stability and function of Gene V Protein; free energy balance in protein folding; modelling protein stability as a heteropolymer collapse; stability of alpha helices; protein stability with T4 Lysozyme.
Frontiers in Protein Structure, Function, and Dynamics
Title | Frontiers in Protein Structure, Function, and Dynamics PDF eBook |
Author | Dev Bukhsh Singh |
Publisher | Springer Nature |
Pages | 458 |
Release | 2020-07-02 |
Genre | Science |
ISBN | 9811555303 |
This book discusses a broad range of basic and advanced topics in the field of protein structure, function, folding, flexibility, and dynamics. Starting with a basic introduction to protein purification, estimation, storage, and its effect on the protein structure, function, and dynamics, it also discusses various experimental and computational structure determination approaches; the importance of molecular interactions and water in protein stability, folding and dynamics; kinetic and thermodynamic parameters associated with protein-ligand binding; single molecule techniques and their applications in studying protein folding and aggregation; protein quality control; the role of amino acid sequence in protein aggregation; muscarinic acetylcholine receptors, antimuscarinic drugs, and their clinical significances. Further, the book explains the current understanding on the therapeutic importance of the enzyme dopamine beta hydroxylase; structural dynamics and motions in molecular motors; role of cathepsins in controlling degradation of extracellular matrix during disease states; and the important structure-function relationship of iron-binding proteins, ferritins. Overall, the book is an important guide and a comprehensive resource for understanding protein structure, function, dynamics, and interaction.
Thermostable Proteins
Title | Thermostable Proteins PDF eBook |
Author | Srikanta Sen |
Publisher | CRC Press |
Pages | 184 |
Release | 2016-04-19 |
Genre | Science |
ISBN | 143983914X |
This book covers the basic structural, thermodynamic and kinetic principles are covered and molecular strategies for the adaptation to high temperatures revealed by structure analysis are delineated. The roles of fluctuations, hydration and internal packing are thoroughly dicussed. Enzymes with a particular industrial importance, the subtilisin-like serine proteases, have been extensively studied by protein engineering. One extensive chapter is devoted to the present state of knowledge concerning structure-function relations and the origin of the their structural stability. Last but not least, computational and experimental approaches for the design of proteins with increased thermal stability based on sequences or 3D structures are present