Protein Structure, Stability, and Folding

Protein Structure, Stability, and Folding
Title Protein Structure, Stability, and Folding PDF eBook
Author Kenneth P. Murphy
Publisher Springer Science & Business Media
Pages 258
Release 2008-02-04
Genre Science
ISBN 1592591930

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In Protein Structure, Stability, and Folding, Kenneth P. Murphy and a panel of internationally recognized investigators describe some of the newest experimental and theoretical methods for investigating these critical events and processes. Among the techniques discussed are the many methods for calculating many of protein stability and dynamics from knowledge of the structure, and for performing molecular dynamics simulations of protein unfolding. New experimental approaches presented include the use of co-solvents, novel applications of hydrogen exchange techniques, temperature-jump methods for looking at folding events, and new strategies for mutagenesis experiments. Unique in its powerful combination of theory and practice, Protein Structure, Stability, and Folding offers protein and biophysical chemists the means to gain a more comprehensive understanding of some of this complex area by detailing many of the major techniques in use today.

Protein Stability and Folding

Protein Stability and Folding
Title Protein Stability and Folding PDF eBook
Author Bret A. Shirley
Publisher
Pages 377
Release 1995
Genre Science
ISBN 9781592595273

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In Protein Stability and Folding: Theory and Practice, world-class scientists present in a single volume a comprehensive selection of hands-on recipes for all of the major techniques needed to understand the conformational stability of proteins, as well as their three-dimensional folding. The distinguished contributors provide clear, step-by-step instructions along with many troubleshooting tips, alternative procedures, and informative explanations about why certain steps are necessary. Even highly skilled researchers will find many time-saving methods. Among the techniques discussed are fluorescent, ultraviolet, and infrared spectroscopy; HPLC peptide mapping; differential scanning calorimetry; and hydrogen exchange. Shirley's Protein Stability and Folding: Theory and Practice will ensure a significant difference in the outcome of your experiments, producing the result desired even for beginners.

Rational Design of Stable Protein Formulations

Rational Design of Stable Protein Formulations
Title Rational Design of Stable Protein Formulations PDF eBook
Author John F. Carpenter
Publisher Springer Science & Business Media
Pages 218
Release 2012-12-06
Genre Medical
ISBN 1461505577

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Recombinant proteins and polypeptides continue to be the most important class of biotechnology-derived agents in today's pharmaceutical industry. Over the past few years, our fundamental understanding of how proteins degrade and how stabilizing agents work has made it possible to approach formulation of protein pharmaceuticals from a much more rational point of view. This book describes the current level of understanding of protein instability and the strategies for stabilizing proteins under a variety of stressful conditions.

Formulation, Characterization, and Stability of Protein Drugs

Formulation, Characterization, and Stability of Protein Drugs
Title Formulation, Characterization, and Stability of Protein Drugs PDF eBook
Author Rodney Pearlman
Publisher Springer Science & Business Media
Pages 455
Release 2006-04-11
Genre Medical
ISBN 0306474522

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Leading scientists offer detailed profiles of ten protein drugs currently in development. The case histories of these important new compounds are described from the perspective of their formulation, characterization, and stability. This ready reference also features recent data and an abundance of previously unpublished information. The in-depth coverage includes a highly useful compendium of degradation sites occurring in over 70 proteins. An invaluable aid in the rapid identification of potential `hot spots' in proteins, this accessible compilation allows for inspection of the protein's primary structure and preparation of a hydroflex plot.

Protein Stability

Protein Stability
Title Protein Stability PDF eBook
Author David S. Eisenberg
Publisher
Pages 334
Release 1995
Genre Science
ISBN 9780120342464

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The topics covered by this volume include: protein destabilization at low temperatures; engineering the stability and function of Gene V Protein; free energy balance in protein folding; modelling protein stability as a heteropolymer collapse; stability of alpha helices; protein stability with T4 Lysozyme.

Protein Stability and Folding

Protein Stability and Folding
Title Protein Stability and Folding PDF eBook
Author Wolfgang Pfeil
Publisher Springer Science & Business Media
Pages 662
Release 2012-12-06
Genre Science
ISBN 3642587607

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Protein folding remains one of the most exclusive problems of modern biochemistry. Structure analysis has given access to the wealth of the molecular architecture of pro teins. As architecture needs static calculations, protein structure is always related to thermodynamic factors that govern folding and stability of a particular folded protein over the non-organized polypeptide chain. During the past decades a huge amount of thermodynamic data related to protein folding and stability has been accumulated. The data are certainly of importance in dechiffring the protein folding problem. At the same time, the data can guide the con struction of modified and newly synthesized proteins with properties optimized for particular application. The intention of this book is a generation of a data collection which makes the vast amount of present data accessible for multidisciplinary research where chemistry, phy sics, biology, and medicine are involved and also pharmaceutical and food research and technology. It took several years to compile all the data and the author wishes to thank everyone who provided data, ideas or even unpublished results. The author is, in particular, indebted to Prof. Wadso (Lund, Sweden) and IUPAC's Steering Committee on Bio physical Chemistry. Furthermore, support by the Deutsche Forschungsgemeinschafi (INK 16 AI-I) is acknowledged.

Molecular Biology of the Cell

Molecular Biology of the Cell
Title Molecular Biology of the Cell PDF eBook
Author
Publisher
Pages 0
Release 2002
Genre Cells
ISBN 9780815332183

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