Protein Conformational Dynamics
Title | Protein Conformational Dynamics PDF eBook |
Author | Ke-li Han |
Publisher | Springer Science & Business Media |
Pages | 488 |
Release | 2014-01-20 |
Genre | Medical |
ISBN | 3319029703 |
This book discusses how biological molecules exert their function and regulate biological processes, with a clear focus on how conformational dynamics of proteins are critical in this respect. In the last decade, the advancements in computational biology, nuclear magnetic resonance including paramagnetic relaxation enhancement, and fluorescence-based ensemble/single-molecule techniques have shown that biological molecules (proteins, DNAs and RNAs) fluctuate under equilibrium conditions. The conformational and energetic spaces that these fluctuations explore likely contain active conformations that are critical for their function. More interestingly, these fluctuations can respond actively to external cues, which introduces layers of tight regulation on the biological processes that they dictate. A growing number of studies have suggested that conformational dynamics of proteins govern their role in regulating biological functions, examples of this regulation can be found in signal transduction, molecular recognition, apoptosis, protein / ion / other molecules translocation and gene expression. On the experimental side, the technical advances have offered deep insights into the conformational motions of a number of proteins. These studies greatly enrich our knowledge of the interplay between structure and function. On the theoretical side, novel approaches and detailed computational simulations have provided powerful tools in the study of enzyme catalysis, protein / drug design, protein / ion / other molecule translocation and protein folding/aggregation, to name but a few. This work contains detailed information, not only on the conformational motions of biological systems, but also on the potential governing forces of conformational dynamics (transient interactions, chemical and physical origins, thermodynamic properties). New developments in computational simulations will greatly enhance our understanding of how these molecules function in various biological events.
Protein Conformational Dynamics: a Computational Study
Title | Protein Conformational Dynamics: a Computational Study PDF eBook |
Author | Ferruccio Palazzesi |
Publisher | |
Pages | |
Release | 2015 |
Genre | |
ISBN |
Modeling Protein Conformational Dynamics Using Kinetic Network Models
Title | Modeling Protein Conformational Dynamics Using Kinetic Network Models PDF eBook |
Author | Zhaoning Cui |
Publisher | |
Pages | 151 |
Release | 2013 |
Genre | Proteins |
ISBN |
Bridging the Gap Between Protein Structure and Dynamics
Title | Bridging the Gap Between Protein Structure and Dynamics PDF eBook |
Author | Jeffrey Alan Hanson |
Publisher | |
Pages | 488 |
Release | 2009 |
Genre | |
ISBN |
Protein Conformational Dynamics in a Two-component Signal Transduction System
Title | Protein Conformational Dynamics in a Two-component Signal Transduction System PDF eBook |
Author | Rahul Banerjee |
Publisher | |
Pages | 217 |
Release | 2014 |
Genre | Electronic dissertations |
ISBN | 9781321153163 |
Protein Dynamics
Title | Protein Dynamics PDF eBook |
Author | Dennis R. Livesay |
Publisher | Humana |
Pages | 0 |
Release | 2016-08-23 |
Genre | Science |
ISBN | 9781493963072 |
In Protein Dynamics: Methods and Protocols, expert researchers in the field detail both experimental and computational methods to interrogate molecular level fluctuations. Chapters detail best-practice recipes covering both experimental and computational techniques, reflecting modern protein research. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Protein Dynamics: Methods and Protocols describes the most common and powerful methods used to characterize protein dynamics.
Infrared Measurements of Protein Conformational Dynamics
Title | Infrared Measurements of Protein Conformational Dynamics PDF eBook |
Author | Robert M. Culik |
Publisher | |
Pages | 183 |
Release | 2014 |
Genre | |
ISBN |