Prostaglandins and Thromboxanes explores the two members of the prostanoid class of fatty acid. This book attempts to thoroughly discuss the topic after collecting enough information through research in physical and biological sciences. As the title suggests, the book revolves around prostaglandins and thromboxanes. The book's first chapter contains a discussion on the subject's history, stating the year of discovery and crediting the scientist who coined the names. The chapter ends talking about the possible uses of prostaglandins and thromboxanes in the clinic. The chapters that follow discu...

This volume presents lecture notes from the session of the International School of Pharmacology, at the "Ettore Majorana" Centre, on Advances in Prostaglandins that took place in Erice (Sicily), October 4 to October 15, 1976. The School was a NATO Advanced Study Institute. The aim of this international course was a compre­ hensive discussion by experts in various disciplines of the present status of our knowledge of the biological role of prostaglandins and thromboxanes. The synthesis, metabolism, and function of prosta­ glandins have been evaluated at the cellular level, in isolated tissues, and/or in the intact organism. The mode of action of prostaglandins and their interactions, particularly with cyclic nucleotides, in normal and pathological conditions, has been discussed with the aim of understanding the possible role of these compounds in hormonal regulation and cell response. The prostaglandin biosynthetic capacity of different tissues, under various experimental conditions, in the presence of specific precursors, and the inhibitory ac­ tivity of different agents have been examined to ascer­ tain the relationship between function and metabolism. For these reasons the discussion has also been extended to the methods (biological, immunological, and spectrometric) available for the direct and specific determination of prostaglandins and the evaluation of their synthesis and metabolism. The Editors hope that the book will be useful both to beginners and to those with a long-time interest in prostaglandins. F. Berti B. Samuelsson G. P. Velo v CONTENTS Chemistry of Prostaglandins and Thromboxanes . .

This comprehensive reference work, updated from the first edition, brings together the knowledge and expertise of contributors from around the world. It includes new topics such as prostaglandin synthetase enzyme, new synthetic eicosanoids, innovative analytical methods, the influence of cytokines in the regulation of synthesis and actions, newer eicosanoids that influence the cardiovascular system, and newly discovered roles in reproduction and interactions with nitric oxide. This book satisfies a surge of interest in prostaglandins—NSAIDS (e.g. aspirin) are the biggest selling drugs of all time, and the field has been refreshed by the advent of new types (selective COX-2 inhibitors, anti-leukotiene drugs).

The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments. * Each chapter considers Asthma and COPD in side-by-side contrast and comparison – not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management * Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD * Most extensive reference to primary literature on both Asthma and COPD in one source. * Easy-to-read summaries of the latest advances alongside clear illustrations

The Encyclopedia of Pain includes more than 3,000 entries and provides clear, detailed and up-to-date coverage of the current state of research, and treatment of pain. In addition, detailed essays provide in-depth information on all aspects of nociception and pain, including substrates, causes, pathophysiology, symptoms and signs, diagnoses and treatment. A thousand color figures enhance understanding of this too-little-understood topic. The book is available in print, in online only form, or in a print-online bundle.

This textbook provides an overview of pain management useful to specialists as well as non-specialists, surgeons, and nursing staff.

Dysmenorrhea is estimated to effect upwards of 70% of women during their lifetime and “heavy menstrual periods” is one of the most frequently given reasons for hysterectomy in the United States. Despite the dramatic growth of dysmenorrhea treatment with non-steroidal anti-inflammatory agents (NSADs) in the 1980s, young women continue to go undiagnosed and under treated. The diagnosis and management of heavy menstrual bleeding has even poorer general understanding because of its more complicated etiologies. With a working knowledge of the underlying pathophysiology, all clinicians should be able to establish both the diagnosis and a credible treatment plan that will result in a significant chance of clinical improvement for most patients. This book addresses the pathophysiologic underpinnings of both dysmenorrhea and menorrhagia and provides clinicians with practical approaches to establishing the diagnosis, proven tactics for successful therapeutic interventions and dealing with the challenging atypical case, and effective patient counseling. It teaches principles, including the role prostaglandins play in both conditions, as well as procedures, like surgical options and TENS, providing a balance of the practical and the esoteric. The inclusion of patient education and counseling materials additionally increases its usefulness for the busy clinician. This is an ideal guide for ob/gyn clinicians, residents, and trainees caring for patients with these common, but often misunderstood diseases.