This book is devoted to the collection, interpretation and analysis of population genetic data. Among the topics included here are studies on human evolutionary history, molecular techniques for generating data, statistical and computational techniques for the interpretation of such data, and stochastic models for genealogy and population structure. The chapters reflect the close interaction between experimental molecular biologists and theoreticians. The book will be useful for specialists in the area, as well as mathematicians, statisticians, computer scientists and biologists wanting a brief overview of current problems in the field.

This textbook shows readers how models of the genetic processes involved in evolution are made (including natural selection, migration, mutation, and genetic drift in finite populations), and how the models are used to interpret classical and molecular genetic data. The material is intended for advanced level undergraduate courses in genetics and evolutionary biology, graduate students in evolutionary biology and human genetics, and researchers in related fields who wish to learn evolutionary genetics. The topics covered include genetic variation, DNA sequence variability and its measurement, the different types of natural selection and their effects (e.g. the maintenance of variation, directional selection, and adaptation), the interactions between selection and mutation or migration, the description and analysis of variation at multiple sites in the genome, genetic drift, and the effects of spatial structure.

Genetics and Evolution of Infectious Diseases, Third Edition discusses the evolving field of infectious diseases and their continued impact on the health of populations, especially in resource-limited areas of the world where they must confront the dual burden of death and disability due to infectious and chronic illnesses. Although substantial gains have been made in public health interventions for the treatment, prevention, and control of infectious diseases, in recent decades the world has witnessed the emergence of the human immunodeficiency virus (HIV) and the COVID-19 pandemic, increasing antimicrobial resistance, and the emergence of many new bacterial, fungal, parasitic, and viral pathogens. Fully updated and revised, this new edition presents the consequences of such diseases, the evolution of infectious diseases, the genetics of host-pathogen relationship, and the control and prevention strategies that are, or can be, developed. This book offers valuable information to biomedical researchers, clinicians, public health practitioners, decisions-makers, and students and postgraduates studying infectious diseases, microbiology, medicine, and public health that is relevant to the control and prevention of neglected and emerging worldwide diseases. - Takes an integrated approach to infectious diseases - Provides the latest developments in the field of infectious diseases - Focuses on the contribution of evolutionary and genomic studies for the study and control of transmissible diseases - Includes updated and revised contributions from leading authorities, along with six new chapters

This book assesses the scientific value and merit of research on human genetic differencesâ€"including a collection of DNA samples that represents the whole of human genetic diversityâ€"and the ethical, organizational, and policy issues surrounding such research. Evaluating Human Genetic Diversity discusses the potential uses of such collection, such as providing insight into human evolution and origins and serving as a springboard for important medical research. It also addresses issues of confidentiality and individual privacy for participants in genetic diversity research studies.

A complete account of evolutionary thought in the social, environmental and policy sciences, creating bridges with biology.

This volume not only offers an intellectual biography of one of the most important biologists and social thinkers of the twentieth century but also illuminates the development of evolutionary studies in Russia and in the West. Theodosius Dobzhansky (1900-1975), a creator of the "evolutionary synthesis" and the author of its first modern statement, Genetics and the Origin of Species (1937), founded modern Western population genetics and wrote many popular books on such topics as human evolution, race and racism, equality, and human destiny. In this, the first book devoted to an analysis of the historical, scientific, and cultural dimensions of Dobzhansky's life and thought, an international group of historians, biologists, and philosophers addresses the full span of his career in Russia and the United States. Beginning with the reminiscences of his daughter, Sophia Dobzhansky Coe, these essays cover Dobzhansky's Russian roots (Nikolai L. Krementsov, Daniel A. Alexandrov, Mikhail B. Konashev), the Morgan Lab (Garland E. Allen, William B. Provine, Robert E. Kohler, Richard M. Burian), his scientific legacy (Scott F. Gilbert, Bruce Wallace, Charles E. Taylor), and his social, political, philosophical, and religious thought (Costas B. Krimbas, John Beatty, Diane B. Paul, Michael Ruse). Originally published in 1994. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.