Musculoskeletal diseases are rapidly becoming a major health concern. The incidence of osteoarthritis, the most common arthritic disorder, is increasing steadily due to the graying of the world population. This disease is responsible of human life, a time in for significant morbidity, particularly in the second half which the quality of life is of primary importance. The aim of this publication is to bring to physicians and scientists a comprehensive overview of the field, from molecules to men. The direct costs related to osteoarthritis have been increasing steadily over the years and will soon be comparable to those of other major illnesses, such as cardiovascular diseases. This, of course, does not take into account all of the other costs related to the disease which often cannot be simply calculated in dollars and cents. There has been a great deal of renewed interest in osteoarthritis in the last few decades. This has been brought on by the need to improve our knowledge of all aspects of the disease, especially with regard to its etiopathogenesis and treatment. The most recent findings and developments on the structural, bio chemical, biomechanical and molecular changes observed in clinical and ex perimental osteoarthritis are presented in this book.

This volume addresses the nature of the most common form of arthritis in humans. If osteoarthritis is inevitable (only premature death prevents all of us from being afflicted), it seems essential to facilitate its recognition, prevention, options, and indications for treatment. Progress in understanding this disease has occurred with recognition that it is not simply a degenerative joint disease. Causative factors, such as joint malalignment, ligamentous abnormalities, overuse, and biomechanical and metabolic factors have been recognized as amenable to intervention; genetic factors, less so; with metabolic diseases, intermediate. Its diagnosis is based on recognition of overgrowth of bone at joint margins. This contrasts with overgrowth of bone at vertebral margins, which is not a symptomatic phenomenon and has been renamed spondylosis deformans. Osteoarthritis describes an abnormality of joints, but the severity does not necessarily produce pain. The patient and his/her symptoms need to be treated, not the x-ray.

This volume addresses the nature of the most common form of arthritis in humans. If osteoarthritis is inevitable (only premature death prevents all of us from being afflicted), it seems essential to facilitate its recognition, prevention, options, and indications for treatment. Progress in understanding this disease has occurred with recognition that it is not simply a degenerative joint disease. Causative factors, such as joint malalignment, ligamentous abnormalities, overuse, and biomechanical and metabolic factors have been recognized as amenable to intervention; genetic factors, less so; with metabolic diseases, intermediate. Its diagnosis is based on recognition of overgrowth of bone at joint margins. This contrasts with overgrowth of bone at vertebral margins, which is not a symptomatic phenomenon and has been renamed spondylosis deformans. Osteoarthritis describes an abnormality of joints, but the severity does not necessarily produce pain. The patient and his/her symptoms need to be treated, not the x-ray.

An authoritative investigation of the sources andtreatment of osteoarthritic joint pain Millions of people throughout the world suffer from osteoarthritis (OA)—a medical condition causing its sufferers excruciating pain that is often disabling. This is the first book to offer clinicians an in-depth understanding of the biological sources of osteoarthritic pain and how they can be treated. Here, a team of leading international authorities has contributed state-of-the-art information on: The Neuroscience of Articular Pain—spinal and peripheral mechanisms of joint pain; experimental models for the study of osteoarthritic pain; inflammatory mediators and nociception in arthritis; phantoms in rheumatology; and more Osteoarthritis and Pain—joint mechanisms and neuromuscular aspects of OA; bone pain and pressure in OA joints; structural correlates of OA pain; and more Treatment of Osteoarthritic Pain—general approaches to treatment; treatments targeting pain receptors; treatments targeting biomechanical abnormalities; and treatments targeting inflammation Whether you're a medical professional, researcher, student, or a generalist or specialist focusing on pain or arthritis, this is your one-stop reference for understanding and treating joint pain in osteoarthritis.

Dr. McIlwraith's Joint Disease in the Horse, 2nd Edition is the only book to give you a full account of equine joint disease, combining a thorough, up-to-date survey of scientific advances with a practical guide to both medical and surgical treatments. With contributions from nationally and internationally recognized pioneers in the field, this groundbreaking text offers an overview of joint structure and function and translates the latest information on basic joint pathobiology into practical application for the clinician. Step-by-step guidance on injection techniques and medications, along with a survey of practical arthroscopic surgery and developments, make it a truly indispensable reference for all equine veterinarians treating sports and racing horses. UNIQUE! Unprecedented, state-of-the-art coverage of the pathology, pathogenesis, and clinical diagnosis of traumatic and degenerative joint disease, so you stay in the know. Section on general principles of joint pathobiology provides the background to evaluate and interpret the diagnostic and surgical aspects of disease. Explores treatments for traumatic arthritis and osteoarthritis and other joint entities, offering a broad range of options and up-to-date recommendations for problematic decisions. Addresses recent advances and results in arthroscopic surgery for the acute injury and results including fragment removal, fragment fixation, and synovectomy. Discussion of current research provides insight for difficult cases and calls out the directions in which future arthritis research is headed. More than 325 photographs and line drawings help engage and guide you through procedures and treatments. NEW! Full color throughout with new artwork and a range of new images including radiographs showing both the normal and the disease progression. NEW! Practical step-by-step approach demonstrates the authors' preferred injections methods and shows underlying anatomic correlations. NEW and UPDATED! Restructured and substantially revised to emphasize treatment options, making it a practical, concise, and accessible reference and text. NEW! All-new chapters on drugs and new biological therapies, including stem cells, IRAP, and PRP and thoroughly updated coverage of HA and corticosteroids. NEW! Covers advanced imaging, giving you the latest information available. NEW! Expert advice from Dr. McIlwraith, three new co-editors, and new contributors - all distinguished specialists in the field of joint disease in the horse. Lameness and surgical clinicians describe how to approach the various, specific disease conditions. Equine specific radiologists provide their opinions on the best imaging techniques for defining the disease and making interpretations.

This book is published open access under a CC BY 4.0 license. White Paper on Joint Replacement This White Paper details the status of hip and knee arthroplasty care in Germany. Hip and knee replacements are amongst the most frequently performed procedures and usually become necessarily due to age-related wear of the joint, osteoarthritis and fractures of the femoral neck. In light of demographic change, demands with regard to standards of care and the procedures are likely to rise. Contents • This White Paper contains information on indications, procedures, health economic aspects and the healthcare system stakeholders involved. • It portrays current developments with regard to the prevalence of hip and knee arthroplasty, the healthcare situation and quality of care within the chain of medical care. • This book is complemented by a chapter assessing the current situation from an expert perspective with contributions from renowned experts in the fields of science, medical technology and medical practice. This book addresses people involved in shaping and representing the healthcare system from a variety of fields including medical professions, health insurances and health sciences as well as journalists and patient representatives.

A strong clinical emphasis is present throughout this volume from the first section of commonly presenting problems through to the section addressing problems shared with a range of other clinical sub-specialties.