This book is a comprehensive, focused resource on intraoperative neurophysiological monitoring (IOM). This rapidly evolving field has created a demand for an up-to-date book such as this that builds on foundational concepts necessary to the practice of IOM in the context of anatomy and physiology. Each chapter is designed to not only inform the reader, but to also test the reader on the information presented - therefore promoting practical, problem-based learning. Surpassing the quality of its successful predecessor, Principles of Neurophysiological Assessment, Mapping, and Monitoring, Second Edition, is positioned to suit the needs of residents and fellows studying for the IOM certificate programs, physicians and anesthesiologists practicing IOM, and neurotechnologists both experienced and in training.

In the latest edition of Benzel’s Spine Surgery, renowned neurosurgery authority Dr. Edward C. Benzel, along with new editor Dr. Michael P. Steinmetz, deliver the most up-to-date information available on every aspect of spine surgery. Improved visuals and over 100 brand-new illustrations enhance your understanding of the text, while 26 new chapters cover today's hot topics in the field. A must-have resource for every neurosurgeon and orthopedic spine surgeon, Benzel's Spine Surgery provides the expert, step-by-step guidance required for successful surgical outcomes. Glean essential, up-to-date information in one comprehensive reference that explores the full spectrum of techniques used in spine surgery. Covers today's hot topics in spine surgery, such as pelvic parameters in planning for lumbar fusion; minimally invasive strategies for the treatment of tumors and trauma of the spine; and biologics and stem cells. A total of 18 intraoperative videos allow you to hone your skills and techniques. New editor Michael P. Steinmetz brings fresh insights and improvements to the text. Features the addition of 26 chapters, including: -Biologics in Spine Fusion Surgery -Endoscopic and Transnasal Approaches to the Craniocervical Junction -Cellular Injection Techniques for Discogenic Pain -Minimally Invasive Techniques for Thoracolumbar Deformity -Spinal Cord Herniation and Spontaneous Cerebrospinal Fluid Leak -MIS Versus Open Spine Surgery Extensive revisions to many of the existing chapters present all of the most up-to-date information available on every aspect of spine surgery. Improved visuals and over 100 brand-new illustrations enhance learning and retention.

Intra-operative neuromonitoring (IONM) refers to a diverse and evolving collection of techniques used to provide real-time assurance of neurological integrity during surgery. Most frequently utilised during neurosurgical procedures, the use of IONM has increased dramatically over recent years, and there is an ongoing need for structured and accessible information in its principles, implementation and interpretation. This dynamic book provides a practical overview of IONM, in simple language and clearly illustrated. Uniquely, it is authored by experienced multidisciplinary clinicians affiliated to King’s College Hospital NHS Foundation Trust, a regional neurosciences centre in London, UK. Combining the expertise of anaesthetists, physiologists, surgeons and patients themselves, this guide represents an invaluable source of information for all staff and trainees involved in the pre-, intra- and postoperative care of patients undergoing IONM.

In recent decades, the advances in and consolidation of Intraoperative Neurophysiological Monitoring (IOM) in several highly complex surgical areas have been undeniable. Currently all modalities of neurophysiological tests (SSEP, MEP, EMG, PEATC, VEP, BRAIN MAPPING, ETC) are performed in the operating room, where they are used to provide trans operative information on the patient’s neurological status in real time (monitoring), and to identify neural structures which are at immediate risk (mapping). With the inarguably positive impact of IOM on surgical outcomes, there is an increasing interest in reliable, technically focused literature. This volume provides cutting-edge information in the field of IOM, and highlights new neurophysiological tools being used in various surgeries. The book’s initial sections cover a range of topics, including an anatomical overview, electrical safety, and detailed technical descriptions of the neurophysiological tests used in IOM. The subsequent sections address e.g. the brain, brainstem, spinal cord, vascular and peripheral nerves, epilepsy, head and neck, movement disorders and special topics. Some chapters are accompanied by videos of surgeries and IOM so that the reader will have the real sensation of having been in the operating room and will gain an overview of the key steps. Written by experts in the field of IOM, the book offers a valuable resource for both experienced and early-career neurophysiologists, neurosurgeons, vascular and orthopedic surgeons, and surgeons involved with pelvic procedures. Further, its goal is to provide a real rapport, never before attained, between neurophysiologists and surgeons with a sole focus: excellence in terms of the final outcome.

Developed over the past 25 years, Cortical Brain Stimulation has emerged as a brand new, cutting-edge option for the treatment of intractable neurological and psychiatric disorders. Devoid of the mortality and disabling morbidity that may accompany deep brain stimulation, stimulating the cortex with a minimally invasive surgical approach had initially proved its worth for the treatment of Central and other Neuropathic Pain Syndromes and later for Parkinson Disease, Dystonia, Stroke and Coma rehabilitation, Epilepsy, Depression and Tinnitus. Written by many of the pioneers in the field, this authoritative treatise is a comprehensive presentation - from surgical details, to clinical results and mechanisms of action. It also provides the busy clinician with comparisons with non-invasive cortical stimulation techniques, such as TMS and tDCS. No other book deals with this form of brain stimulation. The clinician will harness the power of this formidable new therapeutic option, which is being further refined with the advent of closed-loop stimulation. Dr Canavero deciphered the genesis of the central pain syndromes, introduced extradural cortical stimulation for Parkinson Disease and the vegetative state and co-introduced extradural cortical stimulation for stroke rehabilitation. He made worldwide news in 2008 for partially restoring consciousness in two vegetative patients, in 2013 for proposing the HEAVEN/GEMINI protocol for human head transplantation and in 2014 for pushing brain stimulation in the setting of criminal psychopathy. His books include: Central Pain Syndrome, Cambridge Univ. Press, 2011 (2nd ed.), Textbook of therapeutic cortical stimulation, Nova Sci, 2009 and two books in Italian on human sexual behavior.

Medicinal Chemistry - Fusion of Traditional and Western Medicine is a textbook intended for students taking courses in the various fields of medicinal chemistry, pharmacy, medical and dental programs. Moreover, people working in the pharmaceutical industry and doctors preparing for Medical Board Exams will also find it useful. Since, new drugs are being developed by multi-disciplinary teams; this E-Book describes new paradigms that are emerging in modern biology, biochemistry and medicine. It is therefore a fusion of traditional and western medicine and between systems thinking and reductionist thinking. The 3rd edition attempts to explain the predictive, preventive, personalized and participatory (P4) paradigm of medicinal chemistry. This edition features new chapters focusing on personalized medicinal chemistry and the endocrine system (with a discussion of bioidentical hormone therapy). Other chapters cover the disease mechanism and associated pharmacology of drugs for several diseases including cancer, metabolic syndrome, diabetes, heart disease, stroke, osteoporosis, neurodegenerative diseases, the immune system and much more. The new edition also includes an overview of emergent medical problems and possible solutions (such as the flu, ebola virus, global climate change, a shortage of medicines, genetic engineering and stem cell therapy). Drugs that have been approved by the FDA since the 1st edition was written are also included. The book concludes with an explanation of systems thinking in medicinal chemistry, an important, yet rarely explored topic in other medicinal chemistry text books.