The diversity of species in which drugs are used for clinical purposes and the emphasis on various classes of drugs make veterinary pharmacology a complex subject. Anatomical and physiological features influence the pharmacokinetic behaviour of a drug in a particular animal and the dosage required. This book is concerned with the basis of species differences, the selection of pharmacokinetic parameters and the interpretation of values obtained. There are chapters on bioavailability and its application to veterinary dosage forms, changes in drug disposition and interspecies scaling, clinical selectivity and stereoisomerism, drug permeation, antimicrobial disposition and specifics related to neonatal animals. The author has gathered all this information together in one place so allowing the reader to make better selection of drug preparations for animal dosages to effectively treat animal diseases. The book will prove valuable to clinical researchers in the areas of pharmacology, anaesthesia, microbial infections and, internal medicine as well as postgraduate students of these disciplines. The Author J Desmond Baggot (MVM, PhD, DSc, FRCVS, DipECVPT) is currently Visiting Professor of Veterinary Pharmacology at the School of Veterinary Medicine, St George's University, Grenada, West Indies. He was a contributing author and co-author of Antimicrobial Therapy in Veterinary Medicine, 3rd Edition (2000) and Development and Formulation of Veterinary Dosage Forms, 2nd Edition (1998) and the author of Principles of Drug Disposition in Domestic Animals (1977). Elucidations of the processes that underline species variation in the disposition of drugs and interpretation of the influence of disease states on drug disposition have been the focus of his research endeavours. He was a member of the Editorial Board of the Journal of Veterinary Pharmacology and Therapeutics from 1978 to 1996. He is a former Professor of Clinical Pharmacology at the School of Veterinary Medicine, University of California, Davis and Preclinical Veterinary Studies at the University of Zimbabwe, Harare.

General principles governing translocation of drugs; The absorption of drugs; Bioavailability; Drug distribution; Comparative patterns of drug biotransformation; Mechanisms of drug excretion; Principles of pharmacokinetics; Some important principles of drug dosage; Drug theraphy in the neonatal animal.

Drug Disposition and Pharmacokinetics The most up-to-date edition of a leading reference in drug disposition and pharmacokinetics In this new, fully-revised edition of Drug Disposition and Pharmacokinetics: Principles and Applications for Medicine, Toxicology and Biotechnology the authors deliver an authoritative and comprehensive discussion of the fate of drug molecules in the body, as well as its implications for pharmacological and clinical effects. The text offers a unique and balanced approach that combines discussion of the specific physical and biological factors affecting the absorption, distribution, metabolism, and excretion of drugs, with mathematical assessments of plasma and body fluid concentrations. The book assumes little prior knowledge and is an ideal reference for practicing professionals in industry as well as researchers and academics. This latest edition provides readers with a new introductory chapter, as well as new chapters covering monoclonal antibodies, the role of stereochemistry in drug disposition and pharmacokinetics, DMPK in non-human species, and the recent use of AI in drug development. Readers will also find: Thorough introductions to drug disposition, pharmacokinetics, and pharmacokinetic modeling In-depth treatments of the kinetics of drug elimination and the relationship between concentration and effect, including PK–PD modeling Comprehensive discussions of predictive pharmacokinetics and the disposition of biological molecules, including peptides and monoclonal antibodies Detailed examinations of the effects of sex, pregnancy, age, and disease, as well as drug monitoring in therapeutics and the use of AI in drug development and treatment Perfect for professionals and researchers working with the scientific aspects of drug disposition in human and veterinary medicine, toxicology, and pharmacology. Drug Disposition and Pharmacokinetics will earn a place in the libraries of students of senior-level courses in pharmacy.

Veterinary Pharmacology and Therapeutics, Ninth Edition is the long awaited update of the gold-standard reference on veterinary pharmacology and therapeutics. The field of veterinary pharmacology continues to evolve and expand and this new edition has been revised to reflect changes in the field. Veterinary Pharmacology and Therapeutics, Ninth Edition is thoroughly revised, updated, and expanded to meet the needs of today’s veterinarians, veterinary students, and animal health researchers.

Handbook of Veterinary Pharmacology is a clear and concise guide to pharmacology concepts and commonly used veterinary drugs. Providing a succinct overview of veterinary pharmacology, this book presents information in a user-friendly outline format to allow quick access to practical drug information. With chapters covering the basic principles, specific drugs, interactions, and legal considerations, Handbook of Veterinary Pharmacology offers up-to-date information on basic and clinical veterinary pharmacology. As an aid to student comprehension, simple line drawings depict the mechanisms of action and study questions with explanations are included at the end of each chapter. Appendices on withdrawal times for drugs in production animals and drug dosages in domestic species are a valuable tool, allowing quick decisions on drug therapy. Handbook of Veterinary Pharmacology is an indispensable text for veterinary students and practitioners.

This book is dedicated to the fundamental clinical signs of astute observation, careful differential diagnosis and analytical therapeutic decision-making in emergency veterinary settings. It clearly defines the physiological and clinical principles fundamental to the management of the critically ill small animal patient. With clear guidelines for organizing an emergency/critical care unit, the book also discusses ethical and legal concerns. The 80 expert authors have created a clinically specific resource for the specialist, residents in training, veterinary practitioners, technicians and students.Published by Teton New Media in the USA and distributed by CRC Press outside of North America.

Lumb & Jones' is the definitive reference in veterinary anesthesia and analgesia, covering all large and small animal species and a full array of clinical conditions and diseases. This new edition is greatly expanded and revised – an essential and comprehensive text for anyone with a special interest in animal anesthesia and analgesia. The ever-increasing importance of pain management is highlighted by new chapters on pain physiology, analgesic medications, acupuncture, physical rehabilitation, and palliative analgesia, and most noticeably is reflected in the book’s new title, Lumb & Jones' Veterinary Anesthesia and Analgesia. This edition brings together over 65 authors, offering a wide breadth and depth of expertise with contributions from anesthesiologists, pharmacologists, surgeons, criticalists, internists and other clinical specialists. Extensive species chapters span the range of small and large animals, including expanded coverage of laboratory, exotic and zoo animal species, aquatic mammals and fish. Later chapters provide detailed coverage of important considerations for specific diseases and types of patients and procedures, including new chapters on the anesthetic management of dental, cancer, orthopedic and equine colic patients. Preliminary sections cover the general principles of anesthesia, physiology and pharmacology, equipment and monitoring, and anesthetic and analgesic techniques. New edition of the definitive reference in veterinary anesthesia Expanded focus on pain management Written by international team of experts including more than 65 contributing authors Covers anesthesia management of domestic and wild species and full array of clinical conditions and diseases