Principles of Animal Extrapolation addresses the conceptual basis for animal extrapolation and provides an abundance of documentation that illustrates how these principles may be applied in the selection of the more appropriate models and in the interpretation of toxicological studies. The book analyzes and documents each specific biological cause of interspecies differences in susceptibility to toxic agents, including differences in absorption, gut flora, tissue distribution, metabolism, mechanisms and efficiencies of repair, and excretion. The problem of the heterogenicity of the human population is addressed through several chapters that assess the availability and prospects of developing predictive animal models for normal humans, as well as selected potential high-risk groups. Other topics presented in this book include the biological basis of regulatory actions involving attempts to extrapolate from exceptionally high exposure levels to realistic values, especially carcinogens; an assessment of genotoxicity tests, their ability to predict carcinogenicity in whole animals, and the manner in which they should be used by regulatory agencies; birth defects; and predicting the risk of human teratogenesis. Principle of Animal Extrapolation is essential for environmental toxicologists. It also provides valuable information to biomedical scientists (especially those involved in drug development and testing) and regulatory personnel in agencies such as the EPA, the OSHA, the NIOSH, and the FDA.

Biomedical research involving animals remains essential for the advancement of the medical, veterinary, agricultural, and biological sciences. Following in the footsteps of its predecessors, the Handbook of Laboratory Animal Science, Volume II, Third Edition: Animal Models explains in great detail the comparative considerations underlying the choic

The conservative nature of animal evolution makes animal models the ideal tool for learning about human biology. The Handbook of Laboratory Animal Science, Second Edition: Animal Models, Volume II addresses the development and application of models in different areas of biomedical research and details the criteria used to choose animal species and

Builds on the message of Sacred Cows and Golden Geese to understand why medical research on animals really harms humans.

This guide book provides references and resources for the complex field of hazardous waste and hazardous materials management. The book is divided into general topics such as air quality, industrial wastewater, pollution prevention, and risk assessment under hazardous waste management and chemical hazards, emergency planning, and hazard communication under hazardous materials management. Each individual section includes a list of annotated bibliographies of the most recent books by major publishers as well as established, standard references. Following the annotated titles, are additional references of books and documents by publishers, technical associations, and governmental agencies (primarily the U.S. Environmental Protection Agency). In general, only references from 1986 onward are included since the technology and regulations affecting hazardous waste and materials are constantly evolving. Additional resources included in the book are video tapes for training and instruction, information services and databases, libraries, agency contacts, technical journals, and a list of publishers and ordering information. This book will be a useful reference to professionals in the environmental field who need an extensive, but concise source of technical information and contacts. The book will be a valuable addition to individual libraries and will fill a current reference void in university libraries, and technical libraries in industry and government. At present there are very few technical bibliographies in the field, and none has covered topics related to hazardous materials and hazardous waste as extensively as this book.