What use is physical chemistry to the student of biochemistry and biology? This central question is answered in this book mainly through the use of worked examples and problems. The book starts by introducing the laws of thermodynamics, and then uses these laws to derive the equations relevant to the student in dealing with chemical equilibria (including the binding of small molecules to proteins), properties of solutions, acids and bases, and oxidation-reduction processes. The student is thus shown how a knowledge of thermodynamic qualities makes it possible to predict whether, and how, a reaction will proceed. Thermodynamics, however, gives no information about how fast a reaction will happen. The study of the rates at which processes occur (kinetics) forms the second main theme of the book. This section poses and answers questions such as `how is the rate of a reaction affected by temperature, pH, ionic strength, and the nature of the reactants? These same ideas are then shown to be useful in the study of enzyme-catalysed reactions.

This book provides an introduction to physical chemistry that is directed toward applications to the biological sciences. Advanced mathematics is not required. This book can be used for either a one semester or two semester course, and as a reference volume by students and faculty in the biological sciences.

This textbook provides an integrated physical and biochemical foundation for undergraduate students majoring in biology or health sciences. It is particularly suitable for students planning to enter the pharmaceutical industry. This new generation of molecular biologists and biochemists will harness the tools and insights of physics and chemistry to exploit the emergence of genomics and systems-level information in biology, and will shape the future of medicine.

The Second Edition of Principles of Physical Biochemistry provides the most current look at the theory and techniques used in the study of the physical chemistry of biological and biochemical molecules--including discussion of mass spectrometry and single-molecule methods. As leading experts in biophysical chemistry, these well-known authors offer unique insights and coverage not available elsewhere. Physical techniques currently used by practicing biochemists, including new chapters dedicated to extended material on mass spectrometry and single-molecule methods are included. The book's streamlined organization groups all hydrodynamic methods in Chapter 5 and combines Raman spectroscopy with the spectroscopy section. Relevant problems and applications help readers develop critical-thinking skills that they can apply to real biochemical and biological situations facing professionals in the industry. Biological Macromolecules; Thermodynamics and Biochemistry; Molecular Thermodynamics; Statistical Thermodynamics; Methods for the Separation and Characterization of Macromolecules; X-Ray Diffraction; Scattering From Solutions of Macromolecules; Quantum Mechanics and Spectros© Absorption Spectros© Linear and Circular Dichroism; Emission Spectros© Nuclear Magnetic Resonance Spectros© Macromolecules in Solution: Thermodynamics and Equilibria; Chemical Equilibria Involving Macromolecules; Mass Spectrometry of Macromolecules; Single-Molecule Methods. A useful reference for biochemistry professionals or for anyone interested in learning more about biochemistry.

"As will be seen, there is not much missing here. I thought that the sections were well balanced, with rarely too much or too little on a given topic...This is a text to be welcomed by both teachers and students." BIOCHEMISTRY & MOLECULAR BIOLOGY EDUCATION (on the first edition) The second edition of this successful textbook explains the basic principles behind the key techniques currently used in the modern biochemical laboratory and describes the pros and cons of each technique and compares one to another. It is non-mathematical, comprehensive and approachable for students who are not physical chemists. A major update of this comprehensive, accessible introduction to physical biochemistry. Includes two new chapters on proteomics and bioinformatics. Introduces experimental approaches with a minimum of mathematics and numerous practical examples. Provides a bibliography at the end of each chapter. Written by an author with many years teaching and research experience, this text is a must-have for students of biochemistry, biophysics, molecular and life sciences and food science.

Motivating students to engage with physical chemistry through biological examples, this textbook demonstrates how the tools of physical chemistry can be used to illuminate biological questions. It clearly explains key principles and their relevance to life science students, using only the most straightforward and relevant mathematical tools. More than 350 exercises are spread throughout the chapters, covering a wide range of biological applications and explaining issues that students often find challenging. These, along with problems at the end of each chapter and end-of-term review questions, encourage active and continuous study. Over 130 worked examples, many deriving directly from life sciences, help students connect principles and theories to their own laboratory studies. Connections between experimental measurements and key theoretical quantities are frequently highlighted and reinforced. Answers to the exercises are included in the book. Fully worked solutions and answers to the review problems, password-protected for instructors, are available at www.cambridge.org/roussel.