The literature of medicine continues to expand at a remarkable pace. The number of papers and monographs published has increased dramatically in the past five years. Nowhere has this increase been as dramatic as in the field of acute and chronic hepatitis. Why then should there be still another book? Despite the sheer volume of words published, it is still difficult to find in anyone volume a compilation of all of the most significant work. Most mono graphs have considered either chronic or acute hepatitis, not both. Few works have addressed both the clinician and the basic scientist. This book addresses both of these audiences and considers both of these diseases. It was designed to provide an authoritative but concise assessment of our changing concepts of acute and chronic hepatitis. It covers what is currently known and, based on the most convincing research, believed about these diseases. To fulfill this ambitious goal, only authors with international reputations in their fields of expertise were invited to contribute. In the evolution of our current thoughts on the pathogenesis and manage ment of acute and chronic hepatitis, our ideas have changed several times. This book presents the facts as they are known today and, in areas where all the facts are not established, presents the well-founded opinions of those considered to be authorities. The authors present established and usually confirmed data and do not deal extensively with areas of speculation or unconfirmed material.

The author’s discussion of Crow tribal history and his vivid descriptions of current reservation life show how the Apsáalooke are adapting to a changing world. By examining pivotal social and religious institutions, including the clan-uncle and clan-aunt relationships, the acquisition and use of medicine, and the Sun Dance, the author show how reciprocity and interdependence weave together Apsáalooke society and help individuals determine their place in clan, society, and cosmos.

Osteopontin is a GRGDS-containing phosphoprotein secreted by most epithelial cells, many cancer cells, and stimulated or activated cells of various types including smooth muscle cells, fibroblasts and macrophages. It is a ligand for the avb3 integrin, promoting cell adhesion and triggering a signal transduction pathway that can influence gene expression. Binding multiple Ca++ ions, osteopontin is involved in the formation and remodelling of mineralised tissues and Ca++ homeostasis; it has also been implicated in host defence mechanisms.

Peter Sís's remarkable biography The Pilot and the Little Prince celebrates the author of The Little Prince, one of the most beloved books in the world. Antoine de Saint-Exupéry was born in France in 1900, when airplanes were just being invented. Antoine dreamed of flying and grew up to be a pilot—and that was when his adventures began. He found a job delivering mail by plane, which had never been done before. He and his fellow pilots traveled to faraway places and discovered new ways of getting from one place to the next. Antoine flew over mountains and deserts. He battled winds and storms. He tried to break aviation records, and sometimes he even crashed. From his plane, Antoine looked down on the earth and was inspired to write about his life and his pilot-hero friends in memoirs and in fiction. A Frances Foster Book This title has Common Core connections.