Postgenomics

Postgenomics
Title Postgenomics PDF eBook
Author Sarah S. Richardson
Publisher Duke University Press
Pages 286
Release 2015-05-29
Genre Science
ISBN 0822375443

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Ten years after the Human Genome Project’s completion the life sciences stand in a moment of uncertainty, transition, and contestation. The postgenomic era has seen rapid shifts in research methodology, funding, scientific labor, and disciplinary structures. Postgenomics is transforming our understanding of disease and health, our environment, and the categories of race, class, and gender. At the same time, the gene retains its centrality and power in biological and popular discourse. The contributors to Postgenomics analyze these ruptures and continuities and place them in historical, social, and political context. Postgenomics, they argue, forces a rethinking of the genome itself, and opens new territory for conversations between the social sciences, humanities, and life sciences. Contributors. Russ Altman, Rachel A. Ankeny, Catherine Bliss, John Dupré, Michael Fortun, Evelyn Fox Keller, Sabina Leonelli, Adrian Mackenzie, Margot Moinester, Aaron Panofsky, Sarah S. Richardson, Sara Shostak, Hallam Stevens

The Postgenomic Condition

The Postgenomic Condition
Title The Postgenomic Condition PDF eBook
Author Jenny Reardon
Publisher University of Chicago Press
Pages 320
Release 2017-12-29
Genre Medical
ISBN 022651045X

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The postgenomic condition: an introduction -- The information of life or the life of information? -- Inclusion: can genomics be antiracist? -- Who represents the human genome? What is the human genome? -- Genomics for the people or the rise of the machines? -- Genomics for the 98 percent? -- The genomic open 2.0: the public v. the public -- Life on Third: knowledge and justice after the genome -- Epilogue

Biocapital

Biocapital
Title Biocapital PDF eBook
Author Kaushik Sunder Rajan
Publisher Duke University Press
Pages 360
Release 2006-04-24
Genre Business & Economics
ISBN 9780822337201

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DIVAn ethnography about the work of genome scientists, entrepreneurs, and policy makers in biotech drug development in the United States and India./div

The Gene

The Gene
Title The Gene PDF eBook
Author Hans-Jörg Rheinberger
Publisher University of Chicago Press
Pages 156
Release 2018-01-26
Genre Science
ISBN 022647478X

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Few concepts played a more important role in twentieth-century life sciences than that of the gene. Yet at this moment, the field of genetics is undergoing radical conceptual transformation, and some scientists are questioning the very usefulness of the concept of the gene, arguing instead for more systemic perspectives. The time could not be better, therefore, for Hans-Jörg Rheinberger and Staffan Müller-Wille's magisterial history of the concept of the gene. Though the gene has long been the central organizing theme of biology, both conceptually and as an object of study, Rheinberger and Müller-Wille conclude that we have never even had a universally accepted, stable definition of it. Rather, the concept has been in continual flux—a state that, they contend, is typical of historically important and productive scientific concepts. It is that very openness to change and manipulation, the authors argue, that made it so useful: its very mutability enabled it to be useful while the technologies and approaches used to study and theorize about it changed dramatically.

Gene Regulation and Metabolism

Gene Regulation and Metabolism
Title Gene Regulation and Metabolism PDF eBook
Author Julio Collado-Vides
Publisher MIT Press
Pages 326
Release 2002
Genre Computers
ISBN 9780262532686

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An overview of current computational approaches to metabolism and gene regulation.

Rethinking Cancer

Rethinking Cancer
Title Rethinking Cancer PDF eBook
Author Bernhard Strauss
Publisher MIT Press
Pages 433
Release 2021-04-27
Genre Science
ISBN 0262045214

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Leading scientists argue for a new paradigm for cancer research, proposing a complex systems view of cancer supported by empirical evidence. Current consensus in cancer research explains cancer as a disease caused by specific mutations in certain genes. After dramatic advances in genome sequencing, never before have we known so much about the individual cancer cell--and yet never before has it been so unclear what to do with this knowledge. In this volume, leading researchers argue for a new theory framework for understanding and treating cancer. The contributors propose a complex systems view of cancer, presenting conceptual building blocks for a new research paradigm supported by empirical evidence. The contributors first discuss the new research framework in terms of theoretical foundations and then take up the relevance of a systems approach, reviewing such topics as nonlinearity, recurrence after treatment, the cellular attractor concept, network theory, and non-coding DNA--the "dark matter" of our genome. They address the temporality of cancer progression, drawing on evolutionary theory and clinical experience. Finally, they cover the dominant role of the tissue microenvironment in cancer, analyzing topics including altered metabolic pathways, the disease-defining influence on metastasis, and the interconnectedness of different environmental niches across levels of organization.

Behavioral Genetics in the Postgenomic Era

Behavioral Genetics in the Postgenomic Era
Title Behavioral Genetics in the Postgenomic Era PDF eBook
Author Robert Plomin
Publisher Amer Psychological Assn
Pages 608
Release 2003
Genre Medical
ISBN 9781557989260

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The Human Genome Project-which has provided a working draft of the sequence of DNA in the human genome - is a remarkable scientific achievement. In this postgenomic world, it appears that all genes and all DNA variation will eventually be known. For behavioral researchers, this is especially exciting because behavioral dimensions and disorders are the most complex traits of all. To understand these traits, we need to understand the roles of many genes and many environmental influences.