As the largest generation in U.S. history - the population born in the two decades immediately following World War II - enters the age of risk for cognitive impairment, growing numbers of people will experience dementia (including Alzheimer's disease and related dementias). By one estimate, nearly 14 million people in the United States will be living with dementia by 2060. Like other hardships, the experience of living with dementia can bring unexpected moments of intimacy, growth, and compassion, but these diseases also affect people's capacity to work and carry out other activities and alter their relationships with loved ones, friends, and coworkers. Those who live with and care for individuals experiencing these diseases face challenges that include physical and emotional stress, difficult changes and losses in their relationships with life partners, loss of income, and interrupted connections to other activities and friends. From a societal perspective, these diseases place substantial demands on communities and on the institutions and government entities that support people living with dementia and their families, including the health care system, the providers of direct care, and others. Nevertheless, research in the social and behavioral sciences points to possibilities for preventing or slowing the development of dementia and for substantially reducing its social and economic impacts. At the request of the National Institute on Aging of the U.S. Department of Health and Human Services, Reducing the Impact of Dementia in America assesses the contributions of research in the social and behavioral sciences and identifies a research agenda for the coming decade. This report offers a blueprint for the next decade of behavioral and social science research to reduce the negative impact of dementia for America's diverse population. Reducing the Impact of Dementia in America calls for research that addresses the causes and solutions for disparities in both developing dementia and receiving adequate treatment and support. It calls for research that sets goals meaningful not just for scientists but for people living with dementia and those who support them as well. By 2030, an estimated 8.5 million Americans will have Alzheimer's disease and many more will have other forms of dementia. Through identifying priorities social and behavioral science research and recommending ways in which they can be pursued in a coordinated fashion, Reducing the Impact of Dementia in America will help produce research that improves the lives of all those affected by dementia.

Gain a thorough understanding of the determinants of health among aging populations, how disparities arise in diverse communities, and what can be done Reducing health disparities among older people is critical to slowing or reversing the individual and societal impacts of aging-related conditions like Alzheimer's and dementia. The field of population science can help us understand disparities and prevent them using community-wide strategies. Population Science Methods and Approaches to Aging and Alzheimer's Disease and Related Dementias Research offers an overview of the population health approach, applying this framework to aging-related conditions and their determinants. By working hand-in-hand with diverse communities to address these conditions we can develop primary and secondary prevention strategies that can increase health equity for all Americans. Included topics range from population health trends and approaches to understanding community and patient engagement to caregiver perspectives and emerging trends. Learn about the population science approach to understanding aging-related health concerns in diverse communities See how factors like race, income, sexual orientation, sleep, and community engagement affect Alzheimer's and related dementias Read about proactive approaches to primary and secondary prevention within aging populations Discover emerging research and public health initiatives currently underway to promote health equity Students, researchers, and practitioners alike will benefit from this primer on participatory approaches to reducing health disparities. This introduction to the landscape of aging research in the most vulnerable of our communities will facilitate creativity, compassion, and meaningful next steps in biomedical and socioecological research, community support, and clinical care.

Almost 25 years have passed since the Demography of Aging (1994) was published by the National Research Council. Future Directions for the Demography of Aging is, in many ways, the successor to that original volume. The Division of Behavioral and Social Research at the National Institute on Aging (NIA) asked the National Academies of Sciences, Engineering, and Medicine to produce an authoritative guide to new directions in demography of aging. The papers published in this report were originally presented and discussed at a public workshop held in Washington, D.C., August 17-18, 2017. The workshop discussion made evident that major new advances had been made in the last two decades, but also that new trends and research directions have emerged that call for innovative conceptual, design, and measurement approaches. The report reviews these recent trends and also discusses future directions for research on a range of topics that are central to current research in the demography of aging. Looking back over the past two decades of demography of aging research shows remarkable advances in our understanding of the health and well-being of the older population. Equally exciting is that this report sets the stage for the next two decades of innovative researchâ€"a period of rapid growth in the older American population.

Gain a thorough understanding of the determinants of health among aging populations, how disparities arise in diverse communities, and what can be done Reducing health disparities among older people is critical to slowing or reversing the individual and societal impacts of aging-related conditions like Alzheimer's and dementia. The field of population science can help us understand disparities and prevent them using community-wide strategies. Population Science Methods and Approaches to Aging and Alzheimer's Disease and Related Dementias Research offers an overview of the population health approach, applying this framework to aging-related conditions and their determinants. By working hand-in-hand with diverse communities to address these conditions we can develop primary and secondary prevention strategies that can increase health equity for all Americans. Included topics range from population health trends and approaches to understanding community and patient engagement to caregiver perspectives and emerging trends. Learn about the population science approach to understanding aging-related health concerns in diverse communities See how factors like race, income, sexual orientation, sleep, and community engagement affect Alzheimer's and related dementias Read about proactive approaches to primary and secondary prevention within aging populations Discover emerging research and public health initiatives currently underway to promote health equity Students, researchers, and practitioners alike will benefit from this primer on participatory approaches to reducing health disparities. This introduction to the landscape of aging research in the most vulnerable of our communities will facilitate creativity, compassion, and meaningful next steps in biomedical and socioecological research, community support, and clinical care.

The Neurobiology of Aging and Alzheimer Disease in Down Syndrome provides a multidisciplinary approach to the understanding of aging and Alzheimer disease in Down syndrome that is synergistic and focused on efforts to understand the neurobiology as it pertains to interventions that will slow or prevent disease. The book provides detailed knowledge of key molecular aspects of aging and neurodegeneration in Down Syndrome by bringing together different models of the diseases and highlighting multiple techniques. Additionally, it includes case studies and coverage of neuroimaging, neuropathological and biomarker changes associated with these cohorts. This is a must-have resource for researchers who work with or study aging and Alzheimer disease either in the general population or in people with Down syndrome, for academic and general physicians who interact with sporadic dementia patients and need more information about Down syndrome, and for new investigators to the aging and Alzheimer/Down syndrome arena. - Discusses the complexities involved with aging and Alzheimer's disease in Down syndrome - Summarizes the neurobiology of aging that requires management in adults with DS and leads to healthier aging and better quality of life into old age - Serves as learning tool to orient researchers to the key challenges and offers insights to help establish critical areas of need for further research

Provides a definitive overview of the complex ecosystem facilitating Alzheimer's Disease drug research and development. Demonstrates a drug's journey from in the lab, clinical trial testing, regulatory review, and marketing by pharmaceutical companies. Details the use of artificial intelligence, clinical trial management, and financing models.

This booklet summarizes what scientists have learned so far and where research is headed. There is no definitive evidence yet about what can prevent Alzheimer's or age-related cognitive decline. What we do know is that a healthy lifestyle-one that includes a healthy diet, physical activity, appropriate weight, and no smoking-can maintain and improve overall health and well-being. Making healthy choices can also lower the risk of certain chronic diseases, like heart disease and diabetes, and scientists are very interested in the possibility that a healthy lifestyle might have a beneficial effect on Alzheimer's as well. In the meantime, as research continues to pinpoint what works to prevent Alzheimer's, people of all ages can benefit from taking positive steps to get and stay healthy.