Polymeric Gene Delivery Systems
Title | Polymeric Gene Delivery Systems PDF eBook |
Author | Yiyun Cheng |
Publisher | Springer |
Pages | 361 |
Release | 2018-09-04 |
Genre | Technology & Engineering |
ISBN | 3319778668 |
The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. The chapter "Polymeric Nanoparticle-Mediated Gene Delivery for Lung Cancer Treatment" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Polymeric Gene Delivery
Title | Polymeric Gene Delivery PDF eBook |
Author | Mansoor M. Amiji |
Publisher | CRC Press |
Pages | 707 |
Release | 2004-09-29 |
Genre | Medical |
ISBN | 0203500474 |
To treat disease or correct genetic disorders using gene therapy, the most suitable vehicle must be able to deliver genes to the appropriate tissues and cells in the body in a specific as well as safe and effective manner. While viruses are the most popular vehicles to date, their disadvantages include toxicity, limited size of genes they can carry
Polymers and Nanomaterials for Gene Therapy
Title | Polymers and Nanomaterials for Gene Therapy PDF eBook |
Author | Ravin Narain |
Publisher | Woodhead Publishing |
Pages | 303 |
Release | 2016-01-09 |
Genre | Science |
ISBN | 0081005210 |
Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy. This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy. Explores current challenges in the research of genetic diseases Discusses polymers for gene therapy and their function in designing advanced materials Provides examples of organic and inorganic nanomaterials for gene therapy Includes labeling, targeting, and assays Looks at characterization, physico-(bio)chemical properties, and applications
Polymeric Drug Delivery Systems
Title | Polymeric Drug Delivery Systems PDF eBook |
Author | Glen S. Kwon |
Publisher | CRC Press |
Pages | 680 |
Release | 2005-04-12 |
Genre | Medical |
ISBN | 9780824725327 |
Emphasizing four major classes of polymers for drug delivery-water-soluble polymers, hydrogels, biodegradable polymers, and polymer assemblies-this reference surveys efforts to adapt, modify, and tailor polymers for challenging molecules such as poorly water-soluble compounds, peptides/proteins, and plasmid DNA.
Electrospun Materials and Their Allied Applications
Title | Electrospun Materials and Their Allied Applications PDF eBook |
Author | Inamuddin |
Publisher | John Wiley & Sons |
Pages | 544 |
Release | 2020-05-27 |
Genre | Technology & Engineering |
ISBN | 1119654866 |
The aim of this book is to explore the history, fundamentals, manufacturing processes, optimization parameters, and applications of electrospun materials. The book includes various types of electrospun materials such as antimicrobial, smart, bioinspired systems. It focuses on the many application areas for electrospun materials such as energy storage and harvesting, catalysis, biomedical including gene delivery and tissue engineering, separation, adsorption and water treatment technologies, packaging. The book emphasizes the enhanced sustainable properties of electrospun materials, with the challenges and future developments being discussed in detail. The chapters are written by top-class researchers and experts from throughout the world.
Polymers in Therapeutic Delivery
Title | Polymers in Therapeutic Delivery PDF eBook |
Author | Associate Professor in the Chemistry Department Tomoko Fujiwara |
Publisher | American Chemical Society |
Pages | 118 |
Release | 2021-04-30 |
Genre | Medical |
ISBN | 9780841238145 |
Polymer-based systems hold great promise for the delivery of genes and drugs, as polymers can be designed and modified to meet new challenges.
Polymers in Drug Delivery
Title | Polymers in Drug Delivery PDF eBook |
Author | Ijeoma F. Uchegbu |
Publisher | CRC Press |
Pages | 426 |
Release | 2006-05-19 |
Genre | Medical |
ISBN | 1000611248 |
Together, the nano explosion and the genomic revolution are ushering in a new frontier in drug delivery. In recent years we've seen how polymers can play a crucial role in controlling the rate of drug release, enhancing solubility and uptake, and limiting degradation and toxicity. In the very near future, they may well be used to deliver gene thera