PNH and the GPI-Linked Proteins
Title | PNH and the GPI-Linked Proteins PDF eBook |
Author | Neal S. Young |
Publisher | Elsevier |
Pages | 293 |
Release | 2000-04-28 |
Genre | Medical |
ISBN | 0080492096 |
Paroxysmal Nocturnal Hemoglobinuria (PNH) has been recognized for over a century. This mysterious disease is now understood at the level of the gene and the protein. The pathophysiology is related to a class of cell surface proteins with distinctive biochemical and physical characteristics. Recently it has been acknowledged that PNH is not rare, and once sensitive assays--based on the chemistry of the proteins--can be applied to many patients.Written by international experts in the field, this book includes a number of distinctive characteristics, such as the clinical features of PNH, the mechanism of hemolysis, the biochemistry of glycosylphosphoinositol anchors, and the chemistry and biophysics of GPI-anchored proteins.This unique and timely volume will have a wide audience, including hematologists and oncologists with a clinical interest in this disease, as well as basic biochemists, immunologists, and cell biologists studying this class of proteins. - Outlines the chemical features of PNH - Explains the mechanism of hemolysis - Includes work on the biochemistry of glycophosphoinositol anchors - Contains descriptions of the chemistry and biophysics of GPI-anchored proteins
Paroxysmal Nocturnal Hemoglobinuria
Title | Paroxysmal Nocturnal Hemoglobinuria PDF eBook |
Author | Yuzuru Kanakura |
Publisher | Springer |
Pages | 351 |
Release | 2017-01-16 |
Genre | Medical |
ISBN | 4431560033 |
This volume reviews the fundamental understanding of this potentially life-threatening disease and the advances in treatment that have been achieved with the use of the monoclonal antibody eculizumab. Although the PIGA gene has been known for many years, the mechanism of clonal dominance in paroxysmal nocturnal hemoglobinuria is still largely unknown. This book, Paroxysmal Nocturnal Hemoglobinuria, discusses the direction of continuing research in this area, as well as the potential for the development of management guidelines. It serves as a valuable source of information for both basic scientists and physicians, especially immunologists targeting GPI-anchored proteins and complements, and hematologists specializing in bone marrow failure.
Paroxysmal Nocturnal Hemoglobinuria and Related Disorders
Title | Paroxysmal Nocturnal Hemoglobinuria and Related Disorders PDF eBook |
Author | M. Omine |
Publisher | Springer Science & Business Media |
Pages | 376 |
Release | 2012-12-06 |
Genre | Medical |
ISBN | 4431678670 |
Few publications focus on the mysterious, genetically acquired disease paroxysmal nocturnal hemoglobinuria (PNH) and the related "intractable" disorders—aplastic anemia and myelodysplastic syndromes. Now, however, the latest understanding of the clinical and molecular genetic aspects of PNH is summarized here in the proceedings of the International Symposium held in Tokyo in 2001. Major topics reviewed include the molecular mechanisms of the PIG-A gene mutation; complement activation and inhibitors; experimental animal models; pathogenesis; the history of PNH research; the natural history of the disease; the mechanism of PNH clone expansion; the emergence of PNH clones under bone marrow failure syndromes; and treatment of the disease by immunosuppressive agents and stem cell transplantation. This book provides an invaluable summary of current research on the fundamental aspects of PNH pathology, presented by renowned experts in the field.
Congenital and Acquired Bone Marrow Failure
Title | Congenital and Acquired Bone Marrow Failure PDF eBook |
Author | Mahmoud Deeb Aljurf |
Publisher | Elsevier |
Pages | 0 |
Release | 2017-01-09 |
Genre | Science |
ISBN | 9780128041529 |
Congenital and Acquired Bone Marrow Failure is a comprehensive guide to congenital and acquired bone marrow failure in adult and pediatric patients. Chapters are divided into two sections, acquired aplastic anemia and inherited bone marrow failure syndromes. Content ranges from the basic, to the translational, and from the epidemiology of acquired aplastic anemia and telomere biology, to the management, treatment, and supportive care of pediatric, adult, and geriatric patients. Contributors are world leading experts in the field of bone marrow failure. The book is required reading for residents, fellows, clinicians, and researchers across hematology, oncology, pathology, bone marrow transplantation, pediatrics, and internal medicine.
Aplastic Anemia
Title | Aplastic Anemia PDF eBook |
Author | Hubert Schrezenmeier |
Publisher | Cambridge University Press |
Pages | 410 |
Release | 2000 |
Genre | Medical |
ISBN | 9780521641012 |
Comprehensive and up-to-date clinical reference, with an emphasis on treatment.
Essentials of Glycobiology
Title | Essentials of Glycobiology PDF eBook |
Author | Ajit Varki |
Publisher | CSHL Press |
Pages | 694 |
Release | 1999 |
Genre | Medical |
ISBN | 9780879696818 |
Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Diagnosis of Blood and Bone Marrow Disorders
Title | Diagnosis of Blood and Bone Marrow Disorders PDF eBook |
Author | Sa A. Wang |
Publisher | Springer |
Pages | 413 |
Release | 2018-06-04 |
Genre | Medical |
ISBN | 3319202790 |
This book focuses on hematopoietic and lymphoid neoplasms that initially present as peripheral blood abnormalities, with either cytopenias or elevated peripheral blood counts, as well as non-neoplastic conditions that may raise concern for a hematologic malignancy. The scope of the book includes myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), mixed myelodysplastic/myeloproliferative neoplasms (MDS/MPN), as well as lymphomas and lymphoid leukemias that typically present initially with peripheral blood abnormalities. Within each category, a comprehensive list of differential diagnoses is discussed. For each disease entity, the reader is updated with new molecular genetic data, biomarkers, and recent applications of immunophenotyping, and how to incorporate the new information in disease diagnosis and classifications is illustrated, including the use of diagnostic algorithms where appropriate. The book employs the revised WHO Classification of Hematopoietic Neoplasms for all disease entities. Diagnosis of Blood and Bone Marrow Disorders will serve as a very useful resource for pathologists, pathologists in training, hematologists and medical technologists who are involved in the clinical work-up of patients with bone marrow and blood neoplasms. It will provide a practical and concise yet comprehensive review.