This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Due to the recent explosion of placebo research at many levels the Editors believe that a volume on Placebo would be a good addition to the Handbook of Experimental Pharmacology series. In particular, this volume will be built up on a meeting on Placebo which will be held in Tuebingen (Germany) in January 2013, and where the most prominent researchers in this field will present and exchange their ideas. The authors who will be invited to write chapters for this volume will be the very same speakers at this meeting, thus guaranteeing high standard and excellence in the topic that will be treated. The approach of the book is mainly pharmacological, including basic research and clinical trials, and the contents range from different medical conditions and systems, such as pain and the immune system, to different experimental approaches, like in vivo receptor binding and pharmacological/behavioral conditioning. Overall, the volume will give an idea of modern placebo research, of timely concepts in both experimental and clinical pharmacology, as well as of modern methods and tools in neuroscience.

A complete reference source on central pain.

Psychodynamic psychotherapy and psychoanalysis have had to defend themselves from a barrage of criticisms throughout their history. In this book David Jopling argues that the changes achieved through therapy are really just functions of placebos that rally the mind's native healing powers. It is a bold new work that delivers yet another blow to Freud and his followers.

A practical guide translating clinical trials findings, across major psychiatric disorders, to devise tailored, evidence-based treatments.

Do antidepressants work? Of course -- everyone knows it. Like his colleagues, Irving Kirsch, a researcher and clinical psychologist, for years referred patients to psychiatrists to have their depression treated with drugs before deciding to investigate for himself just how effective the drugs actually were. Over the course of the past fifteen years, however, Kirsch's research -- a thorough analysis of decades of Food and Drug Administration data -- has demonstrated that what everyone knew about antidepressants was wrong. Instead of treating depression with drugs, we've been treating it with suggestion. The Emperor's New Drugs makes an overwhelming case that what had seemed a cornerstone of psychiatric treatment is little more than a faulty consensus. But Kirsch does more than just criticize: he offers a path society can follow so that we stop popping pills and start proper treatment for depression.

This book is the second of the series about the imperatives for the search for new psychiatry. As stated in my recent 2021 book about: The Search for New Psychiatry, current psychiatric practices have failed many: patients and their families, their doctors and the society at large. That was the end of the 2021 book and the beginning of this book as a follow up in search for pathways to a new and more effective science-based practice Based on its major contributions to the recent successful and expedient development of the Covid 19 vaccines, I am proposing the same pathway of using the new revolution in informatics as the way to save and secure the future of psychiatry and that is what I am recommending in this book reaping the benefit of AI and Big Data Analytics but with a wide open eye on its limits, reliability, risks, unforeseen or unintentional harms. Part Two of the book deals with a number of perineal and also new challenges that continue to require better understanding and resolution. Among the phenomenological and nosological challenges, the recent development by Neurology of its subspeciality of Behavioral Neurology in competition to Neuropsychiatry, is reviewed in terms of an opportunity for integration of the tow subspecialities towards the creation of a new third field of “Clinical Neurosciences”. Other challenges included are: The Subjective /Objective Dichotomy, Lunacy and the Moon- reflections on the interactions of the brain and environment and Woke Psychiatry, what is it? Several other clinical challenges include: The Past is Coming Back as The Future -The Rise, Fall and Rise Again of Psychedelics, Loneliness as the silent disorder and several other challenges. At the end, a postscript has been hastily added in memory of a close friend, a pioneering psychopharmacologist but above all an empathic humanist, Professor Thomas Arthur Ban or as he always preferred, Tom.