About half of all the medicines prescribed by doctors are not taken by their patients. One of the reasons most commonly given by patients for not taking drugs is that they feel unhappy about taking medicines which they do not understand and of which they are afraid. This book attempts to rectify this problem by showing in clear, non-technical language how medicines and other drugs work in the body to reduce the effects of disease. Most chapters include fascinating background information on how some of our most important drugs were discovered, along with intriguing and often amusing anecdotes about the drugs and the people behind their discovery. Each chapter also includes a summary of the key points together with illustrations, photographs or diagrams to summarise the main groups and how they work in the body. The book covers all the major groups of drugs, with complete listings of all the drugs available in the UK and the USA, so that the reader can locate his or her specific drug and read about the actions of the drugs in that group. The various chapters cover drugs used to treat high blood pressure, heart disease, diabetes, nausea, vomiting, diarrhoea, constipation, ulcers, cancers, infections, impotence, incontinence, arthritis, osteoporosis, as well as hormone replacement therapy, oral contraceptives and drugs used in disorders of the brain such as schizophrenia, depression, Parkinson's disease, Alzheimer's disease and epilepsy. There is also a chapter on drugs which are abused such as cannabis, alcohol, nicotine and ecstasy, and a chapter covering some of the poisons we encounter, such as carbon monoxide, arsenic, sheep dip, and the venoms of snakes, spiders, scorpions and marine organisms. Here, then, a fascinating survey of how chemicals have their effects in the body. It shows how drugs work and explains why it is that taking some medicines for many years is far safer than suffering the long-term effects of disease. Pills, Potions and Poisons is an entertaining read that should also help to improve your health and quality of life.

About half of all the medicines prescribed by doctors are not taken by their patients. One of the reasons most commonly given by patients for not taking drugs is that they feel unhappy about taking medicines which they do not understand and of which they are afraid. This book attempts to rectify this problem by showing in clear, non-technical language how medicines and other drugs work in the body to reduce the effects of disease. Most chapters include fascinating background information on how some of our most important drugs were discovered, along with intriguing and often amusing anecdotes about the drugs and the people behind their discovery. Each chapter also includes a summary of the key points together with illustrations, photographs or diagrams to summarise the main groups and how they work in the body. The book covers all the major groups of drugs, with complete listings of all the drugs available in the UK and the USA, so that the reader can locate his or her specific drug and read about the actions of the drugs in that group. The various chapters cover drugs used to treat high blood pressure, heart disease, diabetes, nausea, vomiting, diarrhoea, constipation, ulcers, cancers, infections, impotence, incontinence, arthritis, osteoporosis, as well as hormone replacement therapy, oral contraceptives and drugs used in disorders of the brain such as schizophrenia, depression, Parkinson's disease, Alzheimer's disease and epilepsy. There is also a chapter on drugs which are abused such as cannabis, alcohol, nicotine and ecstasy, and a chapter covering some of the poisons we encounter, such as carbon monoxide, arsenic, sheep dip, and the venoms of snakes, spiders, scorpions and marine organisms. Here, then, a fascinating survey of how chemicals have their effects in the body. It shows how drugs work and explains why it is that taking some medicines for many years is far safer than suffering the long-term effects of disease. Pills, Potions and Poisons is an entertaining read that should also help to improve your health and quality of life.

This book is about elements that kill. Mercury, arsenic, antimony, lead, and thallium can be lethal, as many a poisoner knew too well. Emsley explores the gruesome history of these elements and those who have succumbed to them in a fascinating narrative that weaves together stories of true crime, enduring historical mysteries, tragic accidents, and the science behind it all. The colourful cast includes ancient alchemists, kings, leaders, a pope, several great musicians, and amotley crew of murderers. Among the intriguing accounts is that of the 17th century poet Sir Thomas Overbury, who survived four attempts to poison him with mercury but died when given the poison in enema form - under whose direction remains uncertain. Here, too, is detailed the celebrated case of FlorenceMaybrick, convicted of poisoning her violent husband James with arsenic, but widely believed at the time to be innocent. The question of her guilt is still disputed.Threaded through the book alongside the history is the growing understanding of chemistry, and the effects of different chemical substances on the human body. Thousands suffered the ill effects of poisonous vapours from mercury, lead, and arsenic before the dangers were realized. Hatters went mad because of mercury poisoning, and hundreds of young girls working in factories manufacturing wallpaper in the 19th century were poisoned by the arsenic-based green pigments used for the leaves of thepopular floral designs. Even in the middle of the 20th century, accidental mercury poisoning caused many deaths in Minamata Bay, while leaded petrol poisoned the whole planet, and arsenic still continues to poison millions is Asia.Through vividly told stories of innocent blunders, industrial accidents, poisoners of various hues - cold, cunning, desperate - and deaths that remain a mystery, Emsley here uncovers the dark side of the Periodic Table.

This CD-ROM edition of Silverman's Organic Chemisry of Drug Design and Drug Action, Second Edition reflects the significant changes in the drug industry in recent years, using an accessible interactive approach. This CD-ROM integrates the author's own PowerPoint slides, indexed and linked to the book pages in PDF format. The three-part structure includes an all-electronic text with full-text search capabilites and nearly 800 powerpoint slides. This is a unique and powerful combination of electronic study guide and full book pages. Users can hyperlink seamlessly from the main text to key points and figures on the outline and back again. It serves as a wonderful supplement for instructors as well as a fully integrated text and study aid for students. * Three-part package includes 1) powerpoint, 2) integrated powerpoint and pdf-based text, and 3) fully searchable PDF-based text with index * Includes new full-color illustrations, structures, schemes, and figures as well as extensive chapter problems and exercises * User-friendly buttons transition from overview (study-guide) format to corresponding book page and back with the click of a mouse * Full-text search capabality an incomparable tool for researchers seeking specific references and/or unindexed phrases

Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. - New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations - Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years - Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization

The botanical history of Britain and North West Europe has a dark and a light side. Plants have been used as weapons to harm people, taken deliberately as addictive drugs and also employed as tools in witchcraft and used as magical amulets. Yet many of these same plants have been medicinally vital to numerous European communities; as the author notes, frequently the only difference between a benevolent medicine and a poison is dosage. In this book, which is richly illustrated with modern colour photographs and illustrations from herbals, Robert Bevan-Jones brings together a wealth of documentary and archaeo-botanical sources to discuss the cultural, social (and anti-social) role of the fifty most significant species of poisonous plants and fungi found in Britain, either as natives or as introductions. An introductory essay puts into context the development of British society's knowledge of toxic plants: the 'cultural botany' applied in Britain today has evolved over thousands of years, absorbing information from European texts and importing useful plants from Europe, such as the mandrake. The book's central A to Z section - from aconite to yew - then informs the reader about the history and uses of 43 species of poisonous plants, especially those that have a documented history of medicinal usage. Four important fungi species - death cap, liberty cap, fly agaric and ergot - also have separate essays. As well as the plants' histories and appearance, their chemical constituents receive coverage; these give them powerful and diverse properties, which demand our admiration and respect. The book aims to add to the knowledge offered by field identification guides, and help reduce the risk associated with accidental ingestion. Case histories are given in as much detail as possible and the information will hopefully help the reader understand the properties of plants they may encounter, either in an archaeological, botanical or horticultural context. Most of these plants can yet be found growing in woodlands, parks, botanical gardens, roadsides, waterways, churchyards and abbey sites. This is an essential book not only for botanists and historical ecologists, but also for anyone interested in the toxic plant traditions of Britain and Europe.