A collection of the Nobel lectures delivered by the prizewinners in physiology or medicine for the period 1996-2000. Each lecture is based on the work for which the laureate was awarded the prize. The following is a list of the Nobel laureates during 1996-2000 with a description of the works that won them their prizes: P.C. Doherty and R.M. Zinkernagel (1996) - for their discoveries concerning the specificity of the cell mediated immune defence; S.B. Prusiner (1997) -for his discovery of "prisons - a new biological principle of infection"; R.F. Furchgott, L.J. Ignarro and F. Murad (1998) - for their discoveries concerning nitric oxide as a signalling molecule in the cardiovascular system; G. Blobel (1999) - for the discovery that "proteins have intrinsic signals that govern their transport and localization in the cell"; A. Carlsson, P. Greengard and E.R. Kandel (2000) - for their discoveries concerning "signal transduction in the nervous system".

The ability of cells to sense and respond to changes in oxygenation underlies a multitude of developmental, physiological, and pathological processes. This volume provides a comprehensive compendium of experimental approaches to the study of oxygen sensing in 48 chapters that are written by leaders in their fields.

This unified modeling textbook for students of biomedical engineering provides a complete course text on the foundations, theory and practice of modeling and simulation in physiology and medicine. It is dedicated to the needs of biomedical engineering and clinical students, supported by applied BME applications and examples. Developed for biomedical engineering and related courses: speaks to BME students at a level and in a language appropriate to their needs, with an interdisciplinary clinical/engineering approach, quantitative basis, and many applied examples to enhance learning Delivers a quantitative approach to modeling and also covers simulation: the perfect foundation text for studies across BME and medicine Extensive case studies and engineering applications from BME, plus end-of-chapter exercises

Yeast Genetics: Methods and Protocols is a collection of methods to best study and manipulate Saccharomyces cerevisiae, a truly genetic powerhouse. The simple nature of a single cell eukaryotic organism, the relative ease of manipulating its genome and the ability to interchangeably exist in both haploid and diploid states have always made it an attractive model organism. Genes can be deleted, mutated, engineered and tagged at will. Saccharomyces cerevisiae has played a major role in the elucidation of multiple conserved cellular processes including MAP kinase signaling, splicing, transcription and many others. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Yeast Genetics: Methods and Protocols will provide a balanced blend of classic and more modern genetic methods relevant to a wide range of research areas and should be widely used as a reference in yeast labs.

HE history of high-altitude physiology and medicine is such a rich and T colorful topic that it is perhaps surprising that no one has undertaken a comprehensive account before. There are so many interesting ramifications, from the early balloonists to the various high-altitude expeditions, culminating in the great saga of climbing Mt. Everest without supplementary oxygen. Underpinning this variety is the basic biological challenge of hypoxia and the ways organisms adapt to it, a subject that is of key importance in medicine and many other life sciences, encountered as it is by organisms throughout the animal kingdom. I hope that this book will be of interest to a wide range of people, from biologists and physiologists to pulmonologists and others who manage patients with hypoxemia. The topic should also appeal to those who love the mountains including trekkers, skiers, climbers, and mountaineers. The book begins with a short introductory chapter to set the scene for the non-scientist. It then follows a general chronological sequence beginning with the Greeks and ending with contemporary events. In some places, however some compromises have been made to group together areas of related interest. For example, in Chapter 4 the controversy about oxygen secretion is traced from the 1870s to the 1930s and includes the Anglo-American Pikes Peak Ex pedition of 1911 and the International High-Altitude Expedition to Cerro de Pasco, Peru during 1921-1922. It makes sense to consider these events together.

World Scientific has the exclusive rights to publish in English the entire collection of the Nobel lectures, the prize presentation speeches, and the biographies of the Nobel laureates for the years 1901-2000 in Physics, Chemistry, Physiology or Medicine, Literature, Peace, and 1969-2000 in Economic Sciences. This collection is an essential purchase for all libraries.These Lectures offer a unique historical perspective of the scientific and cultural developments in each of the respective fields and would appeal to a wide range of readers. In addition to the lectures and acceptance speeches, they provide an opportunity to read the Nobel laureates' personal accounts of the many years of preparation and effort that led to their acknowledged achievements. Apart from serving as an invaluable source of information for specialists and researchers, the lectures would also be of interest to those with less specialized knowledge of the particular fields. As such, they would make an excellent source of reference for individuals, libraries, and educational institutions.The most recent additions are the set of 6 volumes from 1996-2000, marking the finale of a memorable 20th century and the threshold of the next century of Nobel Prizes.

This volume is a collection of the Nobel Lectures delivered by the prizewinners, together with their biographies and the presentation speeches at the award ceremonies in Stockholm for the period 2001 - 2005. Each Nobel Lecture is based on the work for which the laureate was awarded the prize. This volume of inspiring lectures should be on the bookshelf of every keen student, teacher and professor of physiology/medicine as well as of those in related fields.The following is a list of the Nobel laureates during 2001 - 2005 with a description of the works that won them their prizes: (2001) Leland H Hartwell, Tim Hunt & Sir Paul Nurse -- for their discoveries of key regulators of the cell cycle; (2002) Sydney Brenner, H Robert Horvitz & John E Sulston -- for their discoveries concerning genetic regulation of organ development and programmed cell death; (2003) Paul C Lauterbur & Sir Peter Mansfield -- for their discoveries concerning magnetic resonance imaging; (2004) Richard Axel & Linda B Buck -- for their discoveries of odorant receptors and the organization of the olfactory system; (2005) Barry J Marshall & J Robin Warren -- for their discovery of the bacterium Helicobacter pylori and its role in gastritis and peptic ulcer disease.