Physical Methods in Heterocyclic Chemistry, Volume V: Handbook of Molecular Dimensions focuses on bond lengths and angles from X-ray crystallography. This book provides a list of known X-ray structure determinations of molecules and ions that contain heterocyclic rings. Comprised of one chapter, this volume starts with an overview of the use of X-ray diffraction for the study of the geometry of molecules of all types. This text then discusses the three primary reasons for the lack of accuracy in bond lengths and angles determined by X-ray diffraction. This book discusses as well the effect of substitution on the bond lengths and angles in a heterocyclic ring system. The reader is also introduced to the various factors influencing the magnitudes of bond lengths and angles in molecules, which include the degree of hybridization, bond orders, electronegativity, interelectronic repulsion, or the equivalent concepts in terms of which these factors may be expressed. Heterocyclic chemists, biochemists, molecular biologists, and researchers will find this book useful.

Determination of Organic Structures by Physical Methods, Volume 5 is a seven-chapter text that discusses the improvements of some established physical methods for organic structure determination. Each chapter of this book examines specific physical method, including electron diffraction, spin saturation labeling, chemically and electro-magnetically induced dynamic nuclear polarization, ion cyclotron resonance spectroscopy, nuclear quadrupole resonance, Mössbauer spectroscopy, and automated analysis systems. The historical developments, principles, instrumentation, and applications to organic chemistry of these methods are discussed. This work will be of value to organic and analytical chemists and researchers.

Physical Methods in Heterocyclic Chemistry, Volume IV, discusses the application of physical methods to organic chemistry, and in particular to heterocyclic chemistry. Since the publication in 1963 of the first two volumes of this treatise, the application of physical methods to organic chemistry, and in particular to heterocyclic chemistry, has proceeded apace. The importance of physical methods to structure determination and to the understanding of inter- and intramolecular interactions has increased no less than the flood of new work. Heterocyclic chemists are thus faced with the necessity of having more to comprehend for the efficient execution of their own work. The present volume includes chapters on electric dipole moments and heteroaromatic reactivity, which originally appeared in Volume I, and chapters on nuclear quadrupole resonance, nuclear magnetic resonance, and infrared spectra, which originally formed part of Volume II. Also included is one new topic: dielectric absorption.

Physical Methods in Heterocyclic Chemistry, Volume III provides information pertinent to ionization constants and ultraviolet spectra. This book discusses the methods for the prediction of ionization constants. Comprised of seven chapters, this volume starts with an overview of the ionization constants of a number of heterocyclic compounds. This text then describes the procedures that are usually followed when molecular structure determinations based on electron diffraction measurements are carried out. Other chapters consider the concept of group frequencies, which rests upon the experimental fact that certain groups of atom give rise to vibrational transitions which are close or at the same frequency irrespective of the particular molecule in which the group occurs. The final chapter deals with the optical rotatory power, which is the only generally accessible physical property by which enantiomers can be distinguished in isolation. Heterocyclic chemists, biochemists, molecular biologists, and researchers will find this book extremely useful.

This book has so closely matched the requirements of its readership over the years that it has become the first choice for chemists worldwide. Heterocyclic chemistry comprises at least half of all organic chemistry research worldwide. In particular, the vast majority of organic work done in the pharmaceutical and agrochemical industries is heterocyclic chemistry. The fifth edition of Heterocyclic Chemistry maintains the principal objective of earlier editions – to teach the fundamentals of heterocyclic reactivity and synthesis in a way that is understandable to second- and third-year undergraduate chemistry students. The inclusion of more advanced and current material also makes the book a valuable reference text for postgraduate taught courses, postgraduate researchers, and chemists at all levels working with heterocyclic compounds in industry. Fully updated and expanded to reflect important 21st century advances, the fifth edition of this classic text includes the following innovations: Extensive use of colour to highlight changes in structure and bonding during reactions Entirely new chapters on organometallic heterocyclic chemistry, heterocyclic natural products, especially in biochemical processes, and heterocycles in medicine New sections focusing on heterocyclic fluorine compounds, isotopically labeled heterocycles, and solid-phase chemistry, microwave heating and flow reactors in the heterocyclic context Essential teaching material in the early chapters is followed by short chapters throughout the text which capture the essence of heterocyclic reactivity in concise resumés suitable as introductions or summaries, for example for examination preparation. Detailed, systematic discussions cover the reactivity and synthesis of all the important heterocyclic systems. Original references and references to reviews are given throughout the text, vital for postgraduate teaching and for research scientists. Problems, divided into straightforward revision exercises, and more challenging questions (with solutions available online), help the reader to understand and apply the principles of heterocyclic reactivity and synthesis.

Provides a one-volume overall picture of the largest of the classical divisions of organic chemistry, suitable for the graduate or advanced undergraduate student, as well as for research workers, both specialists in the field and those engaged in another discipline and requiring knowledge of heterocyclic chemistry. It represents Volume 9 of Comprehensive Heterocyclic Chemistry and utilizes the general chapters which appear in the 8-volume work. The highly systematic coverage given to the subject makes this the most authoritative one-volume account of modern heterocyclic chemistry available.