This book provides a comprehensive overview of the recent trends in various Nanotechnology-based therapeutics and challenges associated with its development. Nanobiotechnology is an interdisciplinary research that has wide applications in the various fields of biomedical research. The book discusses the various facets of the application of Nanotechnology in drug delivery, clinical diagnostics, Nanomedicine and treatment of infectious and chronic diseases. The book also highlights the recent advancements on important devices and applications that are based on Nanotechnology in medicine and brief the regulatory and ethical issues related to nanomedical devices. It also reviews the toxicological profile of various nanomaterials and emphasizes the need for safe nanomaterials for clinical use. Finally, the book discusses the recent developments of potential commercial applications of Nanotechnology.

Photodynamic therapy utilizes photosensitizers together with irradiating light of specific wavelengths interacting with oxygen to generate cytotoxic reactive oxygen species, in particular singlet oxygen, for clinical treatment of several malignant and non-malignant pathologies. Recently, enhanced photodynamic therapy was successfully achieved by using new light sources (i.e., light-emitting diode), novel functional nano-photosensitizers, oxygen supply and synergistic therapy. In addition, photodynamic therapy has been increasingly used in the fields of antimicrobial and antibiofilm activities. This two-volume work highlights the state-of-the-art in enhanced photodynamic therapy for clinical applications.

Today, in the face of resistant microorganisms, aggressive cancers unresponsive to conventional treatments, and the COVID-19 pandemic, the need for advanced and innovative protocols for combating and treating disease is paramount. This book presents basic concepts of photodynamic therapy along with data from clinical research on its use in treating oncologic and other diseases. It also presents innovative strategies in photodynamic therapy, including information on polymer nanoparticles. This book was prepared with great care and by many valuable hands so that we can expand the dissemination of Photodynamic Therapy, as well as motivate for new research.

With today's focus on targeted and minimally invasive therapies, photodynamic therapy (PDT) is now being studied and used to combat many disease states and to investigate critical biological questions. This groundbreaking resource brings you the latest advances in photodynamic therapy and offers you a solid understanding of the design, delivery and dosimetry of the three basic ingredients of PDT - photosensitizers, light and oxygen. The book covers novel areas of mechanistic and innovative translational approaches. Moreover, it gives you an overview of the important medical applications of PDT, including approved treatments, clinical trials, and investigated therapies for cancer and non-malignant diseases.

Persistent Phosphors: From Fundamentals to Applications provides an introduction to the key synthesis methods, characterization methods, physical mechanisms, and applications of this important luminescent materials system. The book covers basic persistent phosphorescence, introducing concepts such as emission, luminescence, phosphorescence, persistent phosphorescence and the development of persistent phosphors. Then, synthesis methods are reviewed and the connections between synthesis methods and improved materials properties are discussed. Characterization methods to investigate the trapping and de-trapping mechanism are also presented. Other sections cover the theoretical framework and energy band engineering models and materials with a focus on activators, hosts, emission bands and excitation bands. Finally, the most relevant applications of persistent phosphors are included for use in displays, safety signs, bio-labels and energy. Persistent Phosphors is an invaluable reference for materials scientists and engineers in academia and R&D. It is a key resource for chemists and physicists. - Presents characterization techniques to reveal the photophysical and photochemical properties of defects for this important category of luminescent materials - Discusses the structural role of defects in polycrystals and the capture-storing-migration-release progress of excited carriers - Demonstrates the synthesis routes and potential applications for persistent phosphor materials

The main objective of this book is to present the recent applications of photodynamic therapy (PDT) in treating cancer and other diseases. The limitations associated with current PDT agents, and the synthetic designs that have been used in various laboratories are also discussed. The utility of certain tumor-avid agent for cancer imaging (fluorescence, PET, MRI) is also summarized. The book also includes the use of delivery vehicles, including nanoparticles in improving the tumor-specificity of the desired agents. The book is basically focused on the translational approach of drug development. By providing certain specific examples, a clear concept of moving a 'product' from the bench to bed-side is also discussed.To have a clear concept of drug development the book is divided in three parts — Medicinal Chemistry, Mechanistic and Clinical studies. Each part includes the contributions from the leading scientists with extensive experience in the respective field. The handbook is assembled by renowned scientists Dr Dougherty, known as the father of PDT, Dr Kessel, well known for his contributions on mechanism of PDT and Dr Pandey for his inventions in developing improved agents for PDT and cancer-imaging.