The untold story behind the Star Trek Television series that almost was the Lost Series.

In cancer research, a traditional phase II trial is designed as a single-arm trial that compares the experimental therapy to a historical control. This simple trial design has led to several adverse issues, including increased false positivity of phase II trial results and negative phase III trials. To rectify these problems, oncologists and biosta

Single-Phase, Two-Phase and Supercritical Natural Circulation Systems provides readers with a deep understanding of natural circulation systems. This book equips the reader with an understanding on how to detect unstable loops to ensure plant safety and reliability, calculate heat transport capabilities, and design effective natural circulation loops, stability maps and parallel channel systems. Each chapter begins with an introduction to the circulation system before discussing each element in detail and analyzing its effect on the performance of the system. The book also presents thermosyphon heat transport devices in nuclear and other industrial plants, a common information need for students and researchers alike. This book is invaluable for engineers, designers, operators and consultants in nuclear, mechanical, electrical and chemical disciplines. - Presents single-phase, two-phase and supercritical natural circulation systems together in one resource to fill an existing knowledge gap - Guides the reader through relevant processes, such as designing, analyzing and generating stability maps and natural circulation loops, calculating heat transport capabilities, and maintaining natural circulation system operations - Includes global case studies and examples to increase understanding, along with important IAEA standards and procedures

The Brain Korea 21 Program (BK21), which seeks to make Korean research universities globally competitive and to produce more high-quality researchers in Korea, provides funding to graduate students and professors who belong to research groups at top universities. The authors develop quantitative and qualitative models to evaluate how well BK21 is fulfilling its goals and make suggestions for further stimulating Korean university research.

Reliably optimizing a new treatment in humans is a critical first step in clinical evaluation since choosing a suboptimal dose or schedule may lead to failure in later trials. At the same time, if promising preclinical results do not translate into a real treatment advance, it is important to determine this quickly and terminate the clinical evaluation process to avoid wasting resources. Bayesian Designs for Phase I–II Clinical Trials describes how phase I–II designs can serve as a bridge or protective barrier between preclinical studies and large confirmatory clinical trials. It illustrates many of the severe drawbacks with conventional methods used for early-phase clinical trials and presents numerous Bayesian designs for human clinical trials of new experimental treatment regimes. Written by research leaders from the University of Texas MD Anderson Cancer Center, this book shows how Bayesian designs for early-phase clinical trials can explore, refine, and optimize new experimental treatments. It emphasizes the importance of basing decisions on both efficacy and toxicity.

(Guitar Method). The Hal Leonard Guitar Method is designed for anyone just learning to play acoustic or electric guitar. It is based on years of teaching guitar students of all ages, and it also reflects some of the best guitar teaching ideas from around the world. Book 1 includes tuning; playing position; musical symbols; notes in first position; C, G, G7, D, D7, A7, and Em chords; rhythms through eighth notes; strumming and picking; over 80 great songs, riffs, and examples.

The terms phase transitions and phase transformations are often used in an interchangeable manner in the metallurgical literature. In Phase Transformations, transformations driven by pressure changes, radiation and deformation and those occurring in nanoscale multilayers are brought to the fore. Order-disorder transformations, many of which constitute very good examples of continuous transformations, are dealt with in a comprehensive manner. Almost all types of phase transformations and reactions that are commonly encountered in inorganic materials are covered and the underlying thermodynamic, kinetic and crystallographic aspects elucidated. - Shows readers the advancements in the field - due to enhanced computing power and superior experimental capability - Drawing upon the background and the research experience of the authors, bringing together a wealth of experience - Written essentially from a physical metallurgists view point